Guardians vs White Sox Prediction, Odds & Player Prop Bets Today – MLB, Jul 22

min read
(AP Photo)
BetMGM Betting @BETMGM Jul 22, 2022, 3:35 PM
  • The White Sox (46-46) are -155 favorites vs the Guardians (46-44)
  • Guardians starting pitcher: Cal Quantrill (6-5), 3.75 ERA
  • White Sox starting pitcher: Lucas Giolito (6-5), 4.68 ERA
  • Watch the game on Apple TV+

The Cleveland Guardians (+125) visit Guaranteed Rate Field to take on the Chicago White Sox (-155) on Friday, July 22, 2022. First pitch is scheduled for 8:10pm EDT in Chicago.

The White Sox are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+125).

The Guardians vs White Sox Over/Under is 8.5 total runs for the game.

So far this season, the Guardians are 46-44 against the spread (ATS), while the White Sox are 43-49 ATS.

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians+1.5 -155O 8.5 -115+125
White Sox -1.5 +125U 8.5 -105-155

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Friday‘s matchup with 58.0% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Guardians and White Sox and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on White Sox vs Guardians and all MLB games with BetMGM


Best Guardians Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

  • Owen Miller has hit the Runs Under in 18 of his last 20 games (+13.70 Units / 32% ROI)
  • Myles Straw has hit the Runs Under in 14 of his last 16 away games (+10.80 Units / 40% ROI)
  • Myles Straw has hit the Hits Under in 24 of his last 43 away games (+10.80 Units / 19% ROI)
  • Jose Ramirez has hit the RBIs Under in 17 of his last 21 away games (+10.75 Units / 31% ROI)
  • Jose Ramirez has hit the Runs Under in 18 of his last 25 games (+9.85 Units / 31% ROI)

Best White Sox Player Prop Best Bets Today

And here are some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

  • Jose Abreu has hit the Singles Over in 36 of his last 49 games (+23.60 Units / 45% ROI)
  • Jose Abreu has hit the Hits Over in 40 of his last 51 games (+22.35 Units / 20% ROI)
  • Jose Abreu has hit the RBIs Under in 36 of his last 44 games at home (+20.25 Units / 23% ROI)
  • Danny Mendick has hit the Runs Over in 10 of his last 11 games (+15.60 Units / 142% ROI)
  • Jake Burger has hit the RBIs Over in 12 of his last 17 games at home (+15.20 Units / 89% ROI)

White Sox vs Guardians Home Run Prop Bets Today

Over Under
AJ Pollock 0.5 +400 0.5 -700
Andrew Vaughn 0.5 +475 0.5 -1000
Gavin Sheets 0.5 +350 0.5 -650
Jose Abreu 0.5 +375 0.5 -650
Josh Harrison 0.5 +625 0.5 -2000

White Sox vs Guardians Total Hits Prop Bets Today

Over Under
AJ Pollock 0.5 -190 0.5 +135
Andrew Vaughn 0.5 -250 0.5 +165
Gavin Sheets 0.5 -200 0.5 +145
Jose Abreu 0.5 -275 0.5 +185
Josh Harrison 0.5 -185 0.5 +130

White Sox vs Guardians RBI Prop Bets Today

Over Under
AJ Pollock 0.5 +180 0.5 -275
Andrew Vaughn 0.5 +175 0.5 -250
Gavin Sheets 0.5 +145 0.5 -200
Jose Abreu 0.5 +130 0.5 -190
Josh Harrison 0.5 +210 0.5 -300

White Sox vs Guardians Strikeout Prop Bets Today

Over Under
Lucas Giolito 5.5 +110 5.5 -155
Cal Quantrill 3.5 -110 3.5 -125
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Total Under in 32 of their last 59 games (+7.85 Units / 12% ROI)
  • The Cleveland Guardians have hit the Moneyline in 39 of their last 71 games (+7.55 Units / 8% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 31 of their last 59 games (+7.15 Units / 11% ROI)
  • The Cleveland Guardians have covered the Run Line in 39 of their last 71 games (+6.45 Units / 7% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 28 of their last 50 games (+5.00 Units / 9% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Total Under in 26 of their last 42 games at home (+10.85 Units / 24% ROI)
  • The Chicago White Sox have hit the Game Total Over in 25 of their last 47 games (+4.60 Units / 9% ROI)
  • The Chicago White Sox have hit the Moneyline in 7 of their last 10 games (+3.70 Units / 28% ROI)
  • The Chicago White Sox have covered the Run Line in 6 of their last 10 games (+1.95 Units / 16% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 3 of their last 5 games (+1.20 Units / 21% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 47-43 against the Run Line (+1.3 Units / 1.16% ROI).

  • 46-44 when betting on the Moneyline for +2.6 Units / 2.38% ROI
  • 41-43 when betting on the total runs Over for -6.45 Units / -6.49% ROI
  • 43-41 when betting on the total runs Under for -2 Units / -2.02% ROI

White Sox Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 43-49 against the Run Line (-7.75 Units / -6.89% ROI).

  • 46-46 when betting on the Moneyline for -8.45 Units / -7.14% ROI
  • 43-44 when betting on the total runs Over for -4.15 Units / -4.13% ROI
  • 44-43 when betting on the total runs Under for -2.95 Units / -2.89% ROI

Cal Quantrill has a strikeout rate of just 30% (63 SO in 208 PAs) with two-strikes this season — 2nd lowest among qualified SPs in MLB; League Avg: 43% — third Percentile.

Right-handed hitters have a miss rate of just 16% (71/444) against Cal Quantrill this season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.

Opponents have a miss rate of just 19% (145/769) against Cal Quantrill this season — 6th lowest among qualified SPs in MLB; League Avg: 25% — eighth Percentile.

Cal Quantrill has allowed a slugging percentage of .870 (20 Total Bases / 23 ABs) in late innings this season — 2nd highest among qualified SPs in MLB; League Avg: .400 — fourth Percentile.

Lucas Giolito: White Sox Starting Pitcher Stats & Trends

Lucas Giolito has allowed an OPS of .982 (222 PA’s) against right-handed batters this season — 2nd highest in MLB among starting pitchers with at least 45 total IP; League Avg: .707 — first Percentile.

Opponents have a miss rate of 28% (31/110) against Lucas Giolito on inside fastballs this season — best in MLB among starting pitchers with at least 45 total IP; League Avg: 15% — 100th Percentile.

Lucas Giolito has allowed a slugging percentage of .599 (118 Total Bases / 197 ABs) against right-handed batters this season — highest in MLB among starting pitchers with at least 45 total IP; League Avg: .402 — 0 Percentile.

Lucas Giolito has allowed a slugging percentage of .558 (58 Total Bases / 104 ABs) on breaking pitches this season — 3rd highest in MLB among starting pitchers with at least 45 total IP; League Avg: .364 — third Percentile.

Guardians Keys to the Game vs. the White Sox

The Guardians are 30-1 (.968) when leading entering the 8th inning this season — 3rd best in MLB; League Avg: .914.

The Guardians are 28-3 (.903) when totaling 10 or more hits this season — best in MLB; League Avg: .715.

The Guardians are 8-38 (.174) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .086.

The Guardians are 19-8 (.704) when scoring in the first inning this season — 10th best in MLB; League Avg: .660.

White Sox Keys to the Game vs. the Guardians

The White Sox are 7-2 (.778) when tied entering the 7th inning this season — best in MLB; League Avg: .500.

The White Sox are just 4-24 (.143) when allowing 10 or more hits this season — tied for 3rd lowest in MLB; League Avg: .285.

The White Sox are 78-13 (.857) when hitting 2 or more home runs since the 2020 season — best in MLB; League Avg: .704.

The White Sox are 27-21 (.562) on the road this season — tied for 6th best in MLB; League Avg: .478.

Guardians hitters are slugging just .323 against LHP this season — lowest in MLB; League Avg: .398.

Guardians hitters have just 439 strikeouts in 2,480 PA’s (18%) against RHP this season — best in MLB; League Avg: 22%.

Guardians hitters have an OPS of just .613 (906 PA’s) against LHP this season — 2nd lowest in MLB; League Avg: .716.

Guardians hitters have missed on just 21% of swings this season — best in MLB; League Avg: 25%.

The White Sox are batting .285 against LHP this season — 2nd best in MLB; League Avg: .246.

The White Sox are batting .272 on the road this season — best in MLB; League Avg: .240.

The White Sox have won just 44% of home games in which they have scored three or more runs in an inning this season — lowest in MLB; League Avg: 78%.

The White Sox are batting just .159 in lefty-lefty matchups since the start of last season — lowest in MLB; League Avg: .227.

Guardians pitchers have walked 17 of 352 batters (5%) over the last 14 days (10 games) — 2nd best in MLB; League Avg: 8%.

Opponents have a groundball rate of 49% against Guardians pitchers this month (17 games) — tied for 2nd highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 51% against Guardians pitchers over the last 14 days (10 games) — highest in MLB; League Avg: 44%.

The Guardians pitchers have allowed 200 barreled balls this season — tied for 3rd most in MLB.

White Sox pitchers have a strikeout rate of 28% in close and late situations since the start of last season — 2nd best in MLB; League Avg: 25%.

Opponents have a miss rate of 28% against White Sox pitchers since the start of last season — 3rd best in MLB; League Avg: 26%.

White Sox pitchers have walked 332 of 3,528 batters (9%) this season — tied for 3rd highest in MLB; League Avg: 8%.

White Sox pitchers have a strikeout rate of 24% with runners in scoring position since the start of last season — 4th best in MLB; League Avg: 22%.

White Sox vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • Yasmani Grandal (White Sox): Back, D10
  • Kyle Crick (White Sox): Elbow, D15
  • Jonathan Stiever (White Sox): Lat, D60
  • Vincent Velasquez (White Sox): Finger, D15
  • Eloy Jiménez (White Sox): Leg, Day-to-Day
  • Garrett Crochet (White Sox): Elbow, D60
  • Aaron Bummer (White Sox): Lat, D15
  • Jacob Burger (White Sox): Hand, D10
  • Daniel Mendick (White Sox): Knee, D60
  • Luis Robert (White Sox): Illness, Day-to-Day
  • Oscar Gonzalez (Guardians): Ribs, D10
  • Cody Morris (Guardians): Shoulder, D60
  • Aaron Civale (Guardians): Wrist, D15
  • Anthony Gose (Guardians): Triceps, D15

Looking for a risk-free bet up to $1,000? Bet now on White Sox vs Guardians and all MLB games with BetMGM


Bet on MLB Odds at BetMGM

At BetMGM, you can bet online with updated MLB betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.

About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.