• The Guardians are -115 favorites vs the White Sox
• Guardians vs White Sox Over / Under today: 7.5 Runs
• Guardians / White Sox TV Channel: GDTV | CHSN

The Cleveland Guardians (-115) visit Rate Field to take on the Chicago White Sox (-105) on June 22, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Guardians are 41-37 against the spread (ATS), while the White Sox are 42-32 ATS.

Guardians vs White Sox Starting Pitchers Today:

• Guardians starting pitcher: Gavin Williams 9-4, 3.82 ERA
• White Sox starting pitcher: Anthony Kay 6-2, 4.61 ERA

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Monday‘s MLB game with 54.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Travis Bazzana has hit the Home Runs Over in 3 of his last 9 away games (+15.30 Units / 170% ROI)
• Rhys Hoskins has hit the Singles Under in 18 of his last 20 away games (+13.75 Units / 34% ROI)
• Rhys Hoskins has hit the Runs Under in 13 of his last 15 away games (+9.25 Units / 32% ROI)
• Rhys Hoskins has hit the Walks Under in 8 of his last 9 games (+6.80 Units / 56% ROI)
• Rhys Hoskins has hit the RBIs Under in 9 of his last 10 games (+6.70 Units / 26% ROI)

And here are some favorite MLB player prop bets for White Sox players for Monday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Sam Antonacci has hit the Home Runs Over in 3 of his last 6 games (+26.00 Units / 433% ROI)
• Colson Montgomery has hit the RBIs Over in 12 of his last 20 games at home (+11.80 Units / 59% ROI)
• Miguel Vargas has hit the Runs Over in 17 of his last 25 games at home (+11.30 Units / 45% ROI)
• Colson Montgomery has hit the Singles Under in 13 of his last 15 games (+9.50 Units / 33% ROI)
• Tristan Peters has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+8.70 Units / 27% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 29 of their last 50 away games (+14.15 Units / 27% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 33 of their last 50 away games (+13.70 Units / 22% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 away games (+13.00 Units / 24% ROI)
• The Cleveland Guardians have hit the Team Total Under in 16 of their last 24 away games (+7.15 Units / 27% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 50 games (+6.40 Units / 10% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Moneyline in 20 of their last 24 games at home (+18.10 Units / 70% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 27 of their last 40 games (+13.45 Units / 28% ROI)
• The Chicago White Sox have covered the Run Line in 19 of their last 24 games at home (+12.50 Units / 36% ROI)
• The Chicago White Sox have hit the Team Total Over in 29 of their last 45 games (+11.55 Units / 22% ROI)
• The Chicago White Sox have hit the Game Total Over in 25 of their last 40 games (+10.70 Units / 24% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 39-38 against the Run Line (-1.6 Units / -1.57% ROI).

• 41-37 when betting on the Moneyline for +3.7 Units / 4% ROI
• 38-40 when betting on the total runs Over for -5.65 Units / -6.62% ROI
• 40-38 when betting on the total runs Under for -2.15 Units / -2.49% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 42-32 against the Run Line (-2.05 Units / -1.87% ROI).

• 39-37 when betting on the Moneyline for +8.75 Units / 10.99% ROI
• 44-30 when betting on the total runs Over for +11.15 Units / 13.41% ROI
• 30-44 when betting on the total runs Under for -18.75 Units / -22.31% ROI

White Sox vs Guardians Home Run Prop Bets Today

White Sox vs Guardians Total Hits Prop Bets Today

White Sox vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the White Sox

The Guardians are just 1-28 (.034) when trailing entering the 7th inning this season — 2nd lowest in MLB; League Avg: .140.

The Guardians are 22-14 (.611) after a loss this season — 3rd best in MLB; League Avg: .489.

The Guardians are 13-2 (.867) when they’ve hit 2 or more home runs this season — 2nd best in MLB; League Avg: .705.

The Guardians are 15-10 (.600) when tied entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .500.

White Sox Keys to the Game vs. the Guardians

The White Sox are 7-29 (.194) when trailing entering the 7th inning this season — 5th best in MLB; League Avg: .140.

The White Sox are 24-12 (.667) at home this season — 2nd best in MLB; League Avg: .532.

The White Sox are just 3-19 (.136) when allowing 10 or more hits this season — 4th lowest in MLB; League Avg: .247.

The White Sox are just 14-118 (.106) when allowing 10 or more hits since the 2024 season — lowest in MLB; League Avg: .252.

Guardians Hitting Stats & Trends

The Guardians are hitting just .163 against pitchers who have thrown at least 80 pitches in the game this season — lowest in MLB.

Guardians hitters are slugging just .370 this season — 2nd lowest in MLB.

The Guardians are batting just .223 against starting pitchers this season — 2nd lowest in MLB.

Guardians hitters have an OBP of just .277 (327 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

White Sox Hitting Stats & Trends

The White Sox are batting just .136 on pitches out of the zone this season — 3rd lowest in MLB.

White Sox hitters are slugging .435 against LHP this season — 4th best in MLB.

White Sox hitters have missed on 28% of swings this season — highest in MLB.

White Sox hitters have an OPS of just .989 (539 PA’s) with the pitcher behind in the count this season — 4th lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 25% this season — 4th best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — tied for 2nd best in MLB.

Guardians pitchers have a strikeout rate of 32% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 28% in late innings this season — best in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

White Sox pitchers have walked 10% of batters this season — tied for 4th highest in MLB.

White Sox pitchers have an ERA of 3.41 (333.0 IP) at home this season — 4th best in MLB.

The longest HR allowed by the White Sox pitchers this season traveled 443.8 feet — — 4th shortest in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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