Guardians vs White Sox Prediction, Odds & Player Prop Bets Today – MLB, Sep 21

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MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 21, 2022, 3:30 PM
  • The White Sox (76-72) are -135 favorites vs the Guardians (81-67)
  • Guardians starting pitcher: Triston McKenzie (10-11), 3.08 ERA
  • White Sox starting pitcher: Michael Lynn (7-5), 3.99 ERA
  • Watch the game on NBCS-CHI

The Cleveland Guardians (+110) visit Guaranteed Rate Field to take on the Chicago White Sox (-135) on Wednesday, September 21, 2022. First pitch is scheduled for 8:10pm EDT in Chicago.

The White Sox are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+150).

The Guardians vs White Sox Over/Under is 8 total runs for the game.

So far this season, the Guardians are 81-66 against the spread (ATS), while the White Sox are 66-80 ATS.

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians+1.5 -185O 8 -110+110
White Sox -1.5 +150U 8 -110-135

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s matchup with 51.0% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Guardians and White Sox and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on White Sox vs Guardians and all MLB games with BetMGM


Best Guardians Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

  • Josh Naylor has hit the Runs Under in 25 of his last 31 games (+13.90 Units / 26% ROI)
  • Jose Ramirez has hit the Singles Over in 37 of his last 66 games (+11.85 Units / 18% ROI)
  • Shane Bieber has hit the Pitching Outs Over in 16 of his last 21 games (+10.95 Units / 40% ROI)
  • Steven Kwan has hit the Runs Over in 20 of his last 30 away games (+10.40 Units / 32% ROI)
  • Jose Ramirez has hit the Hits Over in 48 of his last 67 games (+10.20 Units / 7% ROI)

Best White Sox Player Prop Best Bets Today

And here are some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

  • Jose Abreu has hit the Singles Over in 71 of his last 105 games (+30.55 Units / 24% ROI)
  • Jose Abreu has hit the Hits Over in 71 of his last 107 games (+20.30 Units / 9% ROI)
  • Jose Abreu has hit the Total Bases Over in 59 of his last 107 games (+17.80 Units / 16% ROI)
  • Danny Mendick has hit the Runs Over in 10 of his last 11 games (+15.60 Units / 142% ROI)
  • Jake Burger has hit the RBIs Over in 12 of his last 17 games at home (+15.20 Units / 89% ROI)

White Sox vs Guardians Home Run Prop Bets Today

Over Under
AJ Pollock 0.5 +310 0.5 -550
Andrew Vaughn 0.5 +320 0.5 -550
Eloy Jimenez 0.5 +230 0.5 -350
Elvis Andrus 0.5 +350 0.5 -650
Gavin Sheets 0.5 +475 0.5 -1000

White Sox vs Guardians Total Hits Prop Bets Today

Over Under
AJ Pollock 0.5 -225 0.5 +155
Andrew Vaughn 0.5 -250 0.5 +160
Eloy Jimenez 0.5 -250 0.5 +175
Elvis Andrus 0.5 -250 0.5 +160
Gavin Sheets 0.5 -155 0.5 +110

White Sox vs Guardians RBI Prop Bets Today

Over Under
AJ Pollock 0.5 +155 0.5 -225
Andrew Vaughn 0.5 +150 0.5 -225
Eloy Jimenez 0.5 +120 0.5 -175
Elvis Andrus 0.5 +185 0.5 -275
Gavin Sheets 0.5 +210 0.5 -350

White Sox vs Guardians Strikeout Prop Bets Today

Over Under
Lance Lynn 5.5 +105 5.5 -150
Triston McKenzie 5.5 +120 5.5 -165
  • The Cleveland Guardians have hit the Moneyline in 37 of their last 63 away games (+16.05 Units / 21% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 24 of their last 33 away games (+15.25 Units / 40% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 18 of their last 25 away games (+13.60 Units / 45% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Total Under in 17 of their last 30 games (+6.95 Units / 21% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 12 of their last 18 away games (+6.40 Units / 32% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Total Under in 41 of their last 71 games at home (+10.70 Units / 14% ROI)
  • The Chicago White Sox have hit the Moneyline in 13 of their last 19 games (+4.10 Units / 13% ROI)
  • The Chicago White Sox have covered the Run Line in 11 of their last 19 games (+3.10 Units / 15% ROI)
  • The Chicago White Sox have hit the Game Total Over in 7 of their last 12 games (+2.65 Units / 20% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 5 of their last 8 games at home (+1.35 Units / 14% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 76-70 against the Run Line (+2.2 Units / 1.21% ROI).

  • 81-66 when betting on the Moneyline for +15.45 Units / 8.43% ROI
  • 65-73 when betting on the total runs Over for -14.95 Units / -9.26% ROI
  • 73-65 when betting on the total runs Under for +1.25 Units / 0.77% ROI

White Sox Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 66-80 against the Run Line (-15.5 Units / -9% ROI).

  • 75-71 when betting on the Moneyline for -15.5 Units / -7.68% ROI
  • 65-71 when betting on the total runs Over for -11.6 Units / -7.25% ROI
  • 71-65 when betting on the total runs Under for +0.1 Units / 0.06% ROI

Opponents have a groundball rate of just 32% (145/455) against Triston McKenzie this season — lowest among qualified SPs in MLB; League Avg: 44% — second Percentile.

Opponents have a groundball rate of just 31% (53/171) against Triston McKenzie in two-strike counts this season — lowest among qualified SPs in MLB; League Avg: 46% — second Percentile.

Right-handed hitters have a groundball rate of just 32% (88/276) against Triston McKenzie this season — lowest among qualified SPs in MLB; League Avg: 45% — second Percentile.

Triston McKenzie has thrown elevated pitches 46% of the time (239/516) when behind in the count this season — 2nd highest among qualified SPs in MLB; League Avg: 29% — 97th Percentile.

Michael Lynn: White Sox Starting Pitcher Stats & Trends

Right-handed hitters have a line drive rate of just 18% (59/320) against Lance Lynn since the start of last season — 4th lowest in MLB among starting pitchers with at least 154 total IP; League Avg: 24% — 97th Percentile.

Opponents have a miss rate of 42% (118/283) against Lance Lynn on elevated fastballs this season — best in MLB among starting pitchers with at least 73 total IP; League Avg: 26% — 100th Percentile.

Lance Lynn has a strikeout rate of 43% (49 SO in 114 PAs) in PAs ending on elevated fastballs this season — 3rd best in MLB among starting pitchers with at least 73 total IP; League Avg: 24% — 98th Percentile.

Lance Lynn has thrown fastballs 67% of the time (214/319) with runners in scoring position this season — highest in MLB among starting pitchers with at least 73 total IP; League Avg: 44% — 100th Percentile.

Guardians Keys to the Game vs. the White Sox

The Guardians are 15-55 (.214) when trailing entering the 7th inning this season — 2nd best in MLB; League Avg: .119.

The Guardians are 22-7 (.759) when hitting 2 or more home runs this season — 10th best in MLB; League Avg: .710.

The Guardians are 13-6 (.684) when tied entering the 8th inning this season — 5th best in MLB; League Avg: .500.

The Guardians are 48-5 (.906) when totaling 10 or more hits this season — best in MLB; League Avg: .723.

White Sox Keys to the Game vs. the Guardians

The White Sox are 27-5 (.844) when hitting 2 or more home runs this season — 2nd best in MLB; League Avg: .710.

The White Sox are just 6-35 (.146) when allowing 10 or more hits this season — tied for 3rd lowest in MLB; League Avg: .277.

The White Sox are 41-34 (.547) on the road this season — 8th best in MLB; League Avg: .473.

The White Sox are just 7-52 (.119) when allowing 5 or more runs this season — 3rd lowest in MLB; League Avg: .199.

Guardians hitters are slugging just .341 against LHP this season — 2nd lowest in MLB; League Avg: .400.

Guardians hitters have just 725 strikeouts in 4,213 PA’s (17%) against RHP this season — best in MLB; League Avg: 22%.

Guardians hitters have an OPS of just .644 (1,413 PA’s) against LHP this season — 3rd lowest in MLB; League Avg: .715.

Guardians hitters have a = 95 mph’>Hard-Hit Rate of just 28% over the last 14 days (14 games) — lowest in MLB; League Avg: 39%.

The White Sox are batting just .162 in lefty-lefty matchups since the start of last season — lowest in MLB; League Avg: .227.

White Sox hitters have 89 extra-base hits out of 302 total hits (just 29%) with the pitcher behind in the count this season — lowest in MLB; League Avg: 39%.

White Sox hitters have an OPS of .780 (2,805 PA’s) against LHP since the start of last season — 2nd best in MLB; League Avg: .726.

The White Sox are batting .266 on the road this season — 2nd best in MLB; League Avg: .241.

Opponents have a groundball batting average of just .198 against Guardians pitchers with the shift since the start of last season — 2nd best in MLB; League Avg: .223.

The Guardians pitchers have allowed their opponents to score first in just 34% of their games on the road this season — 2nd lowest in MLB; League Avg: 46%.

Opponents have a groundball batting average of just .224 against Guardians pitchers with runners on base since the start of last season — 3rd best in MLB; League Avg: .246.

Guardians pitchers have walked 13 of 318 batters (4%) over the past seven days (8 games) — 2nd best in MLB; League Avg: 8%.

White Sox pitchers have a strikeout rate of 25% since the start of last season — 4th best in MLB; League Avg: 23%.

White Sox pitchers have an ERA of 3.71 (1337.0 IP) on the road since the start of last season — 3rd best in MLB; League Avg: 4.30.

Opponents have a miss rate of 28% against White Sox pitchers since the start of last season — 3rd best in MLB; League Avg: 26%.

White Sox pitchers have a strikeout rate of 46% with two-strikes since the start of last season — 4th best in MLB; League Avg: 43%.

White Sox vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • Kyle Crick (White Sox): Elbow, D60
  • Jonathan Stiever (White Sox): Lat, D60
  • Michael Kopech (White Sox): Shoulder, D15
  • Johnny Cueto (White Sox): Illness, Day-to-Day
  • Timothy Anderson (White Sox): Finger, D10
  • Garrett Crochet (White Sox): Elbow, D60
  • Daniel Mendick (White Sox): Knee, D60
  • Anthony Gose (Guardians): Triceps, D60
  • Zach Plesac (Guardians): Hand, D15

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.