Guardians vs White Sox Prediction, Odds & Player Prop Bets Today – MLB, Sep 22

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MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 22, 2022, 3:30 PM
  • The Guardians (82-67) are -145 favorites vs the White Sox (76-73)
  • Guardians starting pitcher: Shane Bieber (11-8), 2.82 ERA
  • White Sox starting pitcher: Johnny Cueto (7-8), 3.09 ERA
  • Watch the game on MLB Network

The Cleveland Guardians (-145) visit Guaranteed Rate Field to take on the Chicago White Sox (+120) on Thursday, September 22, 2022. First pitch is scheduled for 8:10pm EDT in Chicago.

The Guardians are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+120).

The Guardians vs White Sox Over/Under is 7 total runs for the game.

So far this season, the Guardians are 82-66 against the spread (ATS), while the White Sox are 66-82 ATS.

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +120O 7 +100-145
White Sox +1.5 -145U 7 -120+120

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Thursday‘s matchup with 51.0% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Guardians and White Sox and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on White Sox vs Guardians and all MLB games with BetMGM


Best Guardians Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Guardians players for Thursday‘s game, looking at profitable historical betting trends:

  • Josh Naylor has hit the Runs Under in 25 of his last 32 games (+12.10 Units / 22% ROI)
  • Steven Kwan has hit the Runs Over in 21 of his last 31 away games (+11.65 Units / 35% ROI)
  • Triston McKenzie has hit the Pitching Outs Over in 16 of his last 22 games (+11.00 Units / 41% ROI)
  • Shane Bieber has hit the Pitching Outs Over in 16 of his last 21 games (+10.95 Units / 40% ROI)
  • Jose Ramirez has hit the Singles Over in 37 of his last 67 games (+10.85 Units / 16% ROI)

Best White Sox Player Prop Best Bets Today

And here are some favorite MLB player prop bets for White Sox players for Thursday‘s game, looking at profitable historical betting trends:

  • Jose Abreu has hit the Singles Over in 72 of his last 106 games (+31.55 Units / 24% ROI)
  • Jose Abreu has hit the Hits Over in 72 of his last 108 games (+21.30 Units / 10% ROI)
  • Jose Abreu has hit the Total Bases Over in 59 of his last 108 games (+16.80 Units / 15% ROI)
  • Danny Mendick has hit the Runs Over in 10 of his last 11 games (+15.60 Units / 142% ROI)
  • Jake Burger has hit the RBIs Over in 12 of his last 17 games at home (+15.20 Units / 89% ROI)

White Sox vs Guardians Home Run Prop Bets Today

Over Under
AJ Pollock 0.5 +525 0.5 -1200
Andrew Vaughn 0.5 +500 0.5 -1100
Eloy Jimenez 0.5 +360 0.5 -650
Elvis Andrus 0.5 +550 0.5 -1200
Jose Abreu 0.5 +525 0.5 -1200

White Sox vs Guardians Total Hits Prop Bets Today

Over Under
AJ Pollock 0.5 -175 0.5 +120
Andrew Vaughn 0.5 -190 0.5 +130
Eloy Jimenez 0.5 -200 0.5 +140
Elvis Andrus 0.5 -190 0.5 +130
Jose Abreu 0.5 -200 0.5 +145

White Sox vs Guardians RBI Prop Bets Today

Over Under
AJ Pollock 0.5 +230 0.5 -350
Andrew Vaughn 0.5 +220 0.5 -350
Eloy Jimenez 0.5 +180 0.5 -275
Elvis Andrus 0.5 +260 0.5 -400
Jose Abreu 0.5 +240 0.5 -375

White Sox vs Guardians Strikeout Prop Bets Today

Over Under
Johnny Cueto 2.5 -155 2.5 +110
Shane Bieber 5.5 -150 5.5 +105
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 21 of their last 27 away games (+15.45 Units / 49% ROI)
  • The Cleveland Guardians have hit the Moneyline in 19 of their last 26 away games (+15.00 Units / 48% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 19 of their last 26 away games (+14.85 Units / 47% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Total Under in 17 of their last 31 games (+5.85 Units / 17% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 12 of their last 19 away games (+5.30 Units / 25% ROI)
  • The Chicago White Sox have covered the Run Line in 13 of their last 22 games at home (+4.20 Units / 17% ROI)
  • The Chicago White Sox have hit the Game Total Under in 14 of their last 25 games at home (+3.95 Units / 14% ROI)
  • The Chicago White Sox have hit the Moneyline in 13 of their last 20 games (+2.80 Units / 9% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Total Under in 6 of their last 9 games at home (+2.75 Units / 28% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 5 of their last 9 games at home (+0.35 Units / 3% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 77-70 against the Run Line (+3.2 Units / 1.74% ROI).

  • 82-66 when betting on the Moneyline for +16.55 Units / 8.98% ROI
  • 66-73 when betting on the total runs Over for -13.95 Units / -8.58% ROI
  • 73-66 when betting on the total runs Under for +0.15 Units / 0.09% ROI

White Sox Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 66-82 against the Run Line (-17.95 Units / -10.27% ROI).

  • 75-73 when betting on the Moneyline for -17.8 Units / -8.72% ROI
  • 67-71 when betting on the total runs Over for -9.6 Units / -5.92% ROI
  • 71-67 when betting on the total runs Under for -2.2 Units / -1.34% ROI

Shane Bieber has located his pitches away 59% of the time (423/717) on the first pitch of at-bats this season — highest among qualified SPs in MLB; League Avg: 48% — 100th Percentile.

Shane Bieber has located his pitches away 68% of the time (939/1,374) against right-handed batters this season — highest among qualified SPs in MLB; League Avg: 48% — 100th Percentile.

Opponents are hitting just .185 (42-for-227) against Shane Bieber versus the 2-3-4 hitters this season — best among qualified SPs in MLB; League Avg: .245 — 100th Percentile.

Opponents have a line drive rate of 35% (38/109) against Shane Bieber on elevated fastballs since the start of last season — highest in MLB among starting pitchers with at least 155 total IP; League Avg: 23% — 0 Percentile.

Johnny Cueto: White Sox Starting Pitcher Stats & Trends

Opponents have a miss rate of just 13% (28/217) against Johnny Cueto with runners in scoring position this season — lowest in MLB among starting pitchers with at least 74 total IP; League Avg: 25% — 0 Percentile.

Right-handed hitters have a miss rate of just 18% (106/595) against Johnny Cueto this season — 6th lowest in MLB among starting pitchers with at least 74 total IP; League Avg: 25% — fourth Percentile.

The average home run distance against Johnny Cueto against right-handed batters since the start of last season is 412.4 feet — tied for 2nd highest in MLB among starting pitchers with at least 154 total IP; League Avg: 399.1

The average home run distance against Johnny Cueto since the start of last season is 411.4 feet — 2nd highest in MLB among starting pitchers with at least 154 total IP; League Avg: 399.1

Guardians Keys to the Game vs. the White Sox

The Guardians are 15-55 (.214) when trailing entering the 7th inning this season — 2nd best in MLB; League Avg: .119.

The Guardians are 11-58 (.159) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .085.

The Guardians are 55-4 (.932) when scoring 5 or more runs this season — 4th best in MLB; League Avg: .802.

The Guardians are 13-6 (.684) when tied entering the 8th inning this season — 5th best in MLB; League Avg: .500.

White Sox Keys to the Game vs. the Guardians

The White Sox are just 6-36 (.143) when allowing 10 or more hits this season — 3rd lowest in MLB; League Avg: .276.

The White Sox are 14-2 (.875) when totaling 5 or more extra base hits this season — 7th best in MLB; League Avg: .802.

The White Sox are 69-20 (.775) when allowing 4 or fewer runs this season — 6th best in MLB; League Avg: .705.

The White Sox are 27-5 (.844) when hitting 2 or more home runs this season — 2nd best in MLB; League Avg: .711.

Guardians hitters are slugging just .340 against LHP this season — 2nd lowest in MLB; League Avg: .399.

Guardians hitters have just 1,018 strikeouts in 5,669 PA’s (18%) this season — best in MLB; League Avg: 22%.

Guardians hitters have chased 33% of pitches out of the zone against LHP this season — tied for highest in MLB; League Avg: 29%.

Guardians hitters have put 40% of their swings in play this season — highest in MLB; League Avg: 37%.

White Sox hitters have an OPS of just .443 (268 PA’s) in lefty-lefty matchups since the start of last season — lowest in MLB; League Avg: .652.

White Sox hitters have pulled just 40% of balls they’ve put into play against LHP this season — lowest in MLB; League Avg: 46%.

White Sox hitters have 89 extra-base hits out of 304 total hits (just 29%) with the pitcher behind in the count this season — lowest in MLB; League Avg: 39%.

The White Sox are batting .269 against LHP since the start of last season — 2nd best in MLB; League Avg: .247.

The Guardians pitchers have allowed their opponents to score first in just 34% of their games on the road this season — 2nd lowest in MLB; League Avg: 46%.

Guardians pitchers have walked 84 of 1,339 batters (6%) when facing the leadoff batter in the inning this season — 5th best in MLB; League Avg: 7%.

Opponents have a groundball batting average of just .198 against Guardians pitchers with the shift since the start of last season — 2nd best in MLB; League Avg: .223.

Guardians pitchers have walked 13 of 317 batters (4%) over the past seven days (8 games) — 3rd best in MLB; League Avg: 8%.

White Sox pitchers have a strikeout rate of 46% with two-strikes since the start of last season — 4th best in MLB; League Avg: 43%.

Opponents have a miss rate of 28% against White Sox pitchers since the start of last season — tied for 2nd best in MLB; League Avg: 26%.

White Sox pitchers have a strikeout rate of 25% since the start of last season — tied for 4th best in MLB; League Avg: 23%.

White Sox pitchers have a strikeout rate of 28% in close and late situations since the start of last season — 4th best in MLB; League Avg: 25%.

White Sox vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • Kyle Crick (White Sox): Elbow, D60
  • Jonathan Stiever (White Sox): Lat, D60
  • Michael Kopech (White Sox): Shoulder, D15
  • Johnny Cueto (White Sox): Illness, Day-to-Day
  • Timothy Anderson (White Sox): Finger, D10
  • Garrett Crochet (White Sox): Elbow, D60
  • Daniel Mendick (White Sox): Knee, D60
  • Anthony Gose (Guardians): Triceps, D60
  • Zach Plesac (Guardians): Hand, D15

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.