• The Mariners are -145 favorites vs the Astros
• Mariners vs Astros Over / Under today: 8.5 Runs
• Mariners / Astros TV Channel: MRTV | SCHN

The Seattle Mariners (-145) visit Daikin Park to take on the Houston Astros (+120) on May 12, 2026. First pitch is scheduled for 8:10 pm in Houston, TX.

This season, the Mariners are 20-22 against the spread (ATS), while the Astros are 16-26 ATS.

Mariners vs Astros Starting Pitchers Today:

• Mariners starting pitcher: Bryan Woo 2-2, 4.00 ERA
• Astros starting pitcher: Tatsuya Imai 1-0, 7.57 ERA

Mariners vs. Astros Odds, Run Line, Over/Under & Moneyline

Mariners vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Tuesday‘s MLB game with 58.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Mariners vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Mariners players for Tuesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

• Cole Young has hit the Walks Under in 18 of his last 20 games (+13.25 Units / 28% ROI)
• Josh Naylor has hit the Home Runs Over in 3 of his last 9 away games (+12.60 Units / 140% ROI)
• Cal Raleigh has hit the Hits Under in his last 9 games (+12.10 Units / 134% ROI)
• Luke Raley has hit the Singles Under in 14 of his last 15 games (+11.85 Units / 36% ROI)
• Cole Young has hit the Runs Under in his last 10 games (+10.00 Units / 47% ROI)

And here are some favorite MLB player prop bets for Astros players for Tuesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Braden Shewmake has hit the Home Runs Over in 2 of his last 4 games (+17.00 Units / 425% ROI)
• Yordan Alvarez has hit the Runs Over in 18 of his last 25 games at home (+10.55 Units / 35% ROI)
• Cam Smith has hit the Hits Under in 9 of his last 10 games at home (+10.45 Units / 104% ROI)
• Yordan Alvarez has hit the Walks Under in 16 of his last 20 games (+10.40 Units / 37% ROI)
• Yordan Alvarez has hit the RBIs Under in 13 of his last 15 games (+9.80 Units / 36% ROI)

Mariners Best Bets Today:

• The Seattle Mariners have hit the Team Total Under in 17 of their last 24 away games (+8.40 Units / 29% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 away games (+8.15 Units / 14% ROI)
• The Seattle Mariners have hit the Game Total Under in 13 of their last 20 away games (+6.50 Units / 30% ROI)
• The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in 4 of their last 5 games (+3.05 Units / 58% ROI)
• The Seattle Mariners have hit the Moneyline in 7 of their last 10 away games (+3.05 Units / 22% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 21 of their last 30 games at home (+11.90 Units / 35% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 27 of their last 45 games (+8.20 Units / 16% ROI)
• The Houston Astros have hit the Team Total Under in 10 of their last 13 games (+5.90 Units / 36% ROI)
• The Houston Astros have hit the Moneyline in 5 of their last 11 games (+0.70 Units / 6% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 15-27 against the Run Line (-9.3 Units / -20.83% ROI).

• 20-22 when betting on the Moneyline for -9.4 Units / -15.99% ROI
• 18-23 when betting on the total runs Over for -7.35 Units / -15.86% ROI
• 23-18 when betting on the total runs Under for +3.3 Units / 7.16% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 16-26 against the Run Line (-13.25 Units / -24.81% ROI).

• 16-26 when betting on the Moneyline for -12.4 Units / -24.6% ROI
• 26-15 when betting on the total runs Over for +8.7 Units / 18.37% ROI
• 15-26 when betting on the total runs Under for -13.3 Units / -29.49% ROI

Astros vs Mariners Home Run Prop Bets Today

Astros vs Mariners Total Hits Prop Bets Today

Astros vs Mariners Strikeout Prop Bets Today

Mariners Keys to the Game vs. the Astros

The Mariners are 8-3 (.727) vs top 10 scoring offenses this season Today, they face the Astros (eighth in runs scored).

The Mariners are just 14-3 (.824) when leading entering the 8th inning this season — tied for 5th lowest in MLB; League Avg: .894.

The Mariners are 6-78 (.071) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB; League Avg: .045.

The Mariners are 23-14 (.622) when tied entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .500.

Astros Keys to the Game vs. the Mariners

The Astros are just 4-19 (.174) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .279.

The Astros are just 3-12 (.200) when their opponents score in the first inning this season — 3rd lowest in MLB; League Avg: .374.

The Astros are just 16-23 (.410) when allowing 5 or more extra base hits this season — tied for 2nd lowest in MLB; League Avg: .532.

The Astros are just 1-15 (.062) when allowing 10 or more hits this season — lowest in MLB; League Avg: .245.

Mariners Hitting Stats & Trends

Mariners hitters have an OBP of just .280 (477 PA’s) against LHP this season — 2nd lowest in MLB.

The Mariners are batting just .200 against LHP this season — tied for 2nd lowest in MLB.

Mariners hitters are slugging just .332 against LHP this season — 4th lowest in MLB.

Mariners hitters have an OPS of just .612 (477 PA’s) against LHP this season — 3rd lowest in MLB.

Astros Hitting Stats & Trends

Astros hitters have an OBP of .418 (177 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .344 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .278 on the road this season — 2nd best in MLB.

30% of Astros hitters strikeouts have come on 95+ MPH fastballs this season — 3rd highest in MLB.

Mariners Pitching Stats & Trends

Mariners pitchers have a first-pitch strike rate of 67% this season — highest in MLB.

Mariners pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — tied for 2nd best in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 70% of opposing batters this season — highest in MLB.

Opponents have a swing rate of 51% against the Mariners pitchers this season — highest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 13% of batters this season — highest in MLB.

The Astros have allowed 3.64 runs per game (153/42) in the first 5 innings this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — tied for lowest in MLB.

Astros pitchers have an ERA of 6.88 (103.1 IP) against division opponents this season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Mariners vs Astros and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.