• The Mariners are -160 favorites vs the Cardinals
• Mariners vs Cardinals Over / Under today: 8 Runs
• Mariners / Cardinals TV Channel: MRTV | CATV | KMOV

The Seattle Mariners (-160) visit Busch Stadium to take on the St. Louis Cardinals (+135) on April 24, 2026. First pitch is scheduled for 8:15 pm in St. Louis, MO.

This season, the Mariners are 11-15 against the spread (ATS), while the Cardinals are 13-10 ATS.

Mariners vs Cardinals Starting Pitchers Today:

• Mariners starting pitcher: George Kirby 3-2, 2.97 ERA
• Cardinals starting pitcher: Andre Pallante 2-1, 3.99 ERA

Mariners vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Mariners vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Friday‘s MLB game with 59.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Mariners vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Mariners players for Friday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

• Julio Rodriguez has hit the Total Bases Under in 16 of his last 20 away games (+10.25 Units / 36% ROI)
• Cole Young has hit the Singles Over in 14 of his last 25 games (+9.65 Units / 39% ROI)
• Cole Young has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+9.45 Units / 28% ROI)
• Cole Young has hit the Hits Over in 18 of his last 25 games (+8.50 Units / 26% ROI)
• Cal Raleigh has hit the Home Runs Over in 3 of his last 4 games (+8.35 Units / 209% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Ivan Herrera has hit the Home Runs Over in 3 of his last 8 games (+12.40 Units / 155% ROI)
• Andre Pallante has hit the Strikeouts Under in 13 of his last 15 games at home (+11.20 Units / 60% ROI)
• Andre Pallante has hit the Pitching Outs Under in 18 of his last 25 games (+10.80 Units / 37% ROI)
• Ivan Herrera has hit the Walks Over in 12 of his last 20 games (+9.85 Units / 49% ROI)
• Randy Arozarena has hit the Singles Over in 15 of his last 25 games (+8.80 Units / 35% ROI)

Mariners Best Bets Today:

• The Seattle Mariners have hit the Team Total Under in 29 of their last 45 away games (+10.25 Units / 19% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Under in 27 of their last 45 away games (+8.20 Units / 16% ROI)
• The Seattle Mariners have hit the Game Total Under in 8 of their last 10 away games (+5.90 Units / 54% ROI)
• The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in 13 of their last 23 away games (+2.70 Units / 10% ROI)
• The Seattle Mariners have covered the Run Line in 12 of their last 23 away games (+2.10 Units / 8% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+10.70 Units / 23% ROI)
• The St. Louis Cardinals have hit the Moneyline in 14 of their last 23 games at home (+5.95 Units / 25% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 7 of their last 9 games at home (+4.70 Units / 42% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 17 of their last 30 games (+3.75 Units / 11% ROI)
• The St. Louis Cardinals have covered the Run Line in 6 of their last 8 games (+2.85 Units / 22% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 9-17 against the Run Line (-6.45 Units / -22.91% ROI).

• 11-15 when betting on the Moneyline for -9.25 Units / -24.9% ROI
• 12-14 when betting on the total runs Over for -3.3 Units / -11.54% ROI
• 14-12 when betting on the total runs Under for +0.9 Units / 3.14% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 13-10 against the Run Line (-1.45 Units / -4.08% ROI).

• 14-10 when betting on the Moneyline for +5.6 Units / 22.76% ROI
• 13-10 when betting on the total runs Over for +1.95 Units / 7.41% ROI
• 10-13 when betting on the total runs Under for -4.55 Units / -17.11% ROI

Cardinals vs Mariners Home Run Prop Bets Today

Cardinals vs Mariners Total Hits Prop Bets Today

Cardinals vs Mariners Strikeout Prop Bets Today

Mariners Keys to the Game vs. the Cardinals

The Mariners are just 1-8 (.111) on the road this season — lowest in MLB; League Avg: .459.

The Mariners are just 0-14 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .050.

The Mariners were 70-3 (.959) when leading entering the 8th inning in the 2025 season — best in MLB; League Avg: .909.

The Mariners were 5-59 (.078) when trailing entering the 9th inning in the 2025 season — 5th best in MLB; League Avg: .043.

Cardinals Keys to the Game vs. the Mariners

The Cardinals are 11-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .896.

The Cardinals are 11-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .868.

The Cardinals are 74-4 (.949) when leading entering the 8th inning since the 2025 season — 3rd best in MLB; League Avg: .907.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

Mariners Hitting Stats & Trends

Mariners hitters are slugging just .249 on the road this season — lowest in MLB.

Mariners hitters slugged .712 on the first pitch of at-bats in the 2025 season — best in MLB.

The Mariners are batting just .177 on the road this season — lowest in MLB.

Mariners hitters have an OPS of just .531 (337 PA’s) on the road this season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have 22 extra-base hits out of 100 total hits (just 22%) against starting pitchers this season — lowest in MLB.

The Cardinals are batting just .184 with two outs this season — 2nd lowest in MLB.

The Cardinals are batting just .216 with two outs since the 2025 season — 2nd lowest in MLB.

Cardinals hitters are slugging just .483 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Mariners Pitching Stats & Trends

Mariners pitchers have a first-pitch strike rate of 68% this season — highest in MLB.

The Mariners pitchers have allowed division opponents to score first in just 31% of their games since the 2024 season — lowest in MLB.

Mariners pitchers have allowed an OBP of just .272 (3,132 PA’s) when facing the leadoff batter in the inning since the 2024 season — best in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 71% of opposing batters this season — highest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 33% with two-strikes this season — lowest in MLB.

Cardinals pitchers have struck out just 15% of left-handed batters they faced this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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