• The Mariners are -155 favorites vs the Cardinals
• Mariners vs Cardinals Over / Under today: 7.5 Runs
• Mariners / Cardinals TV Channel: MRTV | CATV

The Seattle Mariners (-155) visit Busch Stadium to take on the St. Louis Cardinals (+125) on April 25, 2026. First pitch is scheduled for 2:15 pm in St. Louis, MO.

This season, the Mariners are against the spread (ATS), while the Cardinals are ATS.

Mariners vs Cardinals Starting Pitchers Today:

• Mariners starting pitcher: Bryan Woo 1-2, 2.23 ERA
• Cardinals starting pitcher: Matthew Liberatore 0-1, 3.67 ERA

Mariners vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Mariners vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Saturday‘s MLB game with 60.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Mariners vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Mariners players for Saturday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

• Josh Naylor has hit the Hits Under in 15 of his last 25 games (+12.25 Units / 44% ROI)
• Josh Naylor has hit the Runs Under in 20 of his last 25 games (+11.75 Units / 27% ROI)
• Cole Young has hit the Singles Over in 15 of his last 25 games (+11.65 Units / 46% ROI)
• J.P. Crawford has hit the Hits Runs and RBIs Under in his last 10 away games (+10.40 Units / 76% ROI)
• Julio Rodriguez has hit the Total Bases Under in 16 of his last 20 away games (+10.25 Units / 35% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Jordan Walker has hit the Home Runs Over in 4 of his last 10 games at home (+16.80 Units / 168% ROI)
• Jordan Walker has hit the Runs Over in 16 of his last 25 games (+13.80 Units / 55% ROI)
• Masyn Winn has hit the Hits Over in his last 9 games (+9.00 Units / 53% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in his last 8 games (+8.75 Units / 109% ROI)
• Ramon Urias has hit the Singles Under in 12 of his last 15 games (+8.35 Units / 41% ROI)

Mariners Best Bets Today:

• The Seattle Mariners have hit the Team Total Under in 29 of their last 45 away games (+10.25 Units / 19% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Under in 27 of their last 45 away games (+7.95 Units / 15% ROI)
• The Seattle Mariners have hit the Game Total Under in 9 of their last 11 away games (+6.90 Units / 57% ROI)
• The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in 13 of their last 24 away games (+1.60 Units / 6% ROI)
• The Seattle Mariners have covered the Run Line in 12 of their last 24 away games (+1.10 Units / 4% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+10.65 Units / 23% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 27 of their last 45 games at home (+6.75 Units / 13% ROI)
• The St. Louis Cardinals have hit the Moneyline in 14 of their last 24 games at home (+4.95 Units / 20% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 23 of their last 40 games at home (+4.10 Units / 9% ROI)
• The St. Louis Cardinals have covered the Run Line in 7 of their last 9 games (+3.85 Units / 27% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Mariners Keys to the Game vs. the Cardinals

The Mariners are 79-4 (.952) when leading entering the 8th inning since the 2025 season — tied for best in MLB; League Avg: .907.

The Mariners are just 0-13 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .103.

The Mariners are just 0-11 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .135.

The Mariners are just 0-14 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

Cardinals Keys to the Game vs. the Mariners

The Cardinals are 11-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .865.

The Cardinals are 74-4 (.949) when leading entering the 8th inning since the 2025 season — 3rd best in MLB; League Avg: .907.

The Cardinals are 11-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .897.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Mariners Hitting Stats & Trends

Mariners hitters are slugging just .251 on the road this season — lowest in MLB.

The Mariners are batting just .173 on the road this season — lowest in MLB.

Mariners hitters have an OPS of just .532 (373 PA’s) on the road this season — lowest in MLB.

Mariners hitters are slugging .682 on the first pitch of at-bats since the 2025 season — 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have 23 extra-base hits out of 105 total hits (just 22%) against starting pitchers this season — lowest in MLB.

Cardinals hitters have an OPS of just .939 (1,338 PA’s) with the pitcher behind in the count since the 2025 season — 2nd lowest in MLB.

Cardinals hitters are slugging just .481 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters are slugging just .376 against RHP since the 2025 season — 3rd lowest in MLB.

Mariners Pitching Stats & Trends

Mariners pitchers have induced opposing hitters to ground into 28 double plays in 184 opportunities (15%) this season — best in MLB.

Mariners pitchers have a first-pitch strike rate of 68% this season — highest in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 71% of opposing batters this season — highest in MLB.

Mariners pitchers have walked 7% of batters this season — best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 34% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 17% this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2025 season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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