Mariners vs Royals Prediction, Odds & Player Prop Bets Today – MLB, May 22

Kansas City Royals' Bobby Witt Jr. celebrates a double against the Detroit Tigers during the fifth inning of a baseball game in Kansas City, Mo., Sunday, June 1, 2025.
(AP Photo/Reed Hoffmann)
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  • The Mariners are -135 favorites vs the Royals
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The Seattle Mariners (-135) visit Kauffman Stadium to take on the Kansas City Royals (+110) on May 22, 2026. First pitch is scheduled for 7:40 pm in Kansas City, MO.

This season, the Mariners are 24-27 against the spread (ATS), while the Royals are 20-28 ATS.

Mariners vs Royals Starting Pitchers Today:

  • Mariners starting pitcher: Logan Gilbert 2-4, 4.43 ERA
  • Royals starting pitcher: Noah Cameron 2-3, 5.36 ERA

Mariners vs. Royals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Mariners-1.5 +125O 8 -105-135
Royals +1.5 -155U 8 -115+110

Mariners vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Friday‘s MLB game with 58.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Mariners players for Friday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

  • Cole Young has hit the Runs Under in 19 of his last 20 games (+16.75 Units / 40% ROI)
  • Rob Refsnyder has hit the Total Bases Under in 15 of his last 20 games (+11.40 Units / 50% ROI)
  • Randy Arozarena has hit the Hits Over in 20 of his last 25 away games (+10.80 Units / 24% ROI)
  • Randy Arozarena has hit the Singles Over in 17 of his last 25 away games (+10.50 Units / 40% ROI)
  • Mitch Garver has hit the Walks Over in 8 of his last 10 games (+9.25 Units / 92% ROI)

And here are some favorite MLB player prop bets for Royals players for Friday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

  • Michael Massey has hit the Home Runs Over in 3 of his last 10 games at home (+18.50 Units / 185% ROI)
  • Carter Jensen has hit the Total Bases Under in 16 of his last 20 games (+12.65 Units / 45% ROI)
  • Isaac Collins has hit the Runs Under in 17 of his last 20 games (+11.25 Units / 29% ROI)
  • Vinnie Pasquantino has hit the Hits Under in 12 of his last 20 games at home (+10.85 Units / 51% ROI)
  • Vinnie Pasquantino has hit the Singles Under in 18 of his last 25 games at home (+9.00 Units / 28% ROI)
  • The Seattle Mariners have hit the Team Total Under in 16 of their last 24 away games (+6.55 Units / 23% ROI)
  • The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 23 games (+6.30 Units / 22% ROI)
  • The Seattle Mariners have hit the Game Total Under in 14 of their last 23 away games (+5.40 Units / 22% ROI)
  • The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in their last 5 away games (+5.05 Units / 83% ROI)
  • The Seattle Mariners have hit the 1st Five Innings (F5) Moneyline in their last 5 away games (+5.00 Units / 67% ROI)
  • The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 32 of their last 50 games (+12.05 Units / 20% ROI)
  • The Kansas City Royals have hit the Team Total Under in their last 7 games (+7.00 Units / 79% ROI)
  • The Kansas City Royals have hit the 1st Five Innings (F5) Moneyline in 11 of their last 19 games at home (+5.85 Units / 22% ROI)
  • The Kansas City Royals have covered the 1st Five Innings (F5) Run Line in 12 of their last 19 games at home (+4.60 Units / 21% ROI)
  • The Kansas City Royals have hit the Game Total Over in 11 of their last 17 games at home (+4.45 Units / 24% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 18-33 against the Run Line (-11.45 Units / -21.24% ROI).

  • 24-27 when betting on the Moneyline for -12.75 Units / -17.66% ROI
  • 23-26 when betting on the total runs Over for -5.75 Units / -10.2% ROI
  • 26-23 when betting on the total runs Under for +0.7 Units / 1.25% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 20-28 against the Run Line (-12.2 Units / -18.33% ROI).

  • 20-30 when betting on the Moneyline for -14.65 Units / -24.44% ROI
  • 22-28 when betting on the total runs Over for -8.55 Units / -15.6% ROI
  • 28-22 when betting on the total runs Under for +3.85 Units / 6.97% ROI

Royals vs Mariners Home Run Prop Bets Today

Yes
Julio Rodriguez +333
Bobby Witt Jr. +425
Salvador Perez +425
Randy Arozarena +450
Vinnie Pasquantino +450

Royals vs Mariners Total Hits Prop Bets Today

Over Under
Maikel Garcia 0.5 -250 0.5 +180
Randy Arozarena 0.5 -235 0.5 +175
J.P. Crawford 0.5 -225 0.5 +165
Josh Naylor 0.5 -210 0.5 +155
Vinnie Pasquantino 0.5 -200 0.5 +145

Royals vs Mariners Strikeout Prop Bets Today

Over Under
Isaac Collins 0.5 -250 0.5 +180
Mitch Garver 0.5 -220 0.5 +160
Randy Arozarena 0.5 -220 0.5 +165
Julio Rodriguez 0.5 -210 0.5 +155
Salvador Perez 0.5 -190 0.5 +140

Mariners Keys to the Game vs. the Royals

The Mariners are just 2-12 (.143) vs bottom 10 scoring offenses this season Today, they face the Royals (28th in runs scored).

The Mariners are just 6-23 (.207) when scoring 4 or fewer runs this season — 5th lowest in MLB; League Avg: .279.

The Mariners are just 18-4 (.818) when leading entering the 8th inning this season — 5th lowest in MLB; League Avg: .894.

The Mariners are 24-15 (.615) when tied entering the 7th inning since the 2025 season — 5th best in MLB; League Avg: .500.

Royals Keys to the Game vs. the Mariners

The Royals are just 15-4 (.789) when leading entering the 8th inning this season — tied for 2nd lowest in MLB; League Avg: .894.

The Royals are just 3-11 (.214) when their opponents score in the first inning this season — 2nd lowest in MLB; League Avg: .364.

The Royals are just 1-14 (.067) when allowing 10 or more hits this season — 2nd lowest in MLB; League Avg: .245.

The Royals are just 9-20 (.310) after a loss this season — 2nd lowest in MLB; League Avg: .475.

The Mariners are batting just .189 against LHP this season — lowest in MLB.

Mariners hitters have put just 31% of their swings in play with runners in scoring position this season — lowest in MLB.

Mariners hitters have an OBP of just .277 (568 PA’s) against LHP this season — tied for lowest in MLB.

The Mariners are batting just .220 with runners on base this season — 2nd lowest in MLB.

Royals hitters are slugging just .338 on the road this season — lowest in MLB.

Royals hitters have an OPS of just .435 (965 PA’s) with two-strikes this season — lowest in MLB.

Royals hitters are slugging just .208 with two-strikes this season — lowest in MLB.

Royals hitters are slugging just .162 on pitches out of the zone this season — tied for 2nd lowest in MLB.

Mariners pitchers have a first-pitch strike rate of 67% this season — highest in MLB.

Mariners pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

Opponents have a swing rate of 51% against the Mariners pitchers this season — highest in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 70% of opposing batters this season — highest in MLB.

Royals pitchers have walked 11% of batters this season — 4th highest in MLB.

Royals pitchers have a strikeout rate of just 19% in close and late situations this season — 4th lowest in MLB.

Royals pitchers have picked-off 9 runners from first base this season — most in MLB.

Royals pitchers have allowed three-ball counts to 24% of batters they faced (447/1,889 PA’s) this season — 2nd highest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.