• The Cubs are -220 favorites vs the Marlins
• Marlins vs Cubs Over / Under today: 6.5 Runs
• Marlins / Cubs TV Channel: MARQ | MATV

The Miami Marlins (+180) visit Wrigley Field to take on the Chicago Cubs (-220) on September 22, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Marlins are 76-80 against the spread (ATS), while the Cubs are 75-79 ATS.

Marlins vs Cubs Starting Pitchers Today:

• Marlins starting pitcher: Janson Junk 6-9, 4.52 ERA
• Cubs starting pitcher: Undecided 0-0, 0.00 ERA

Marlins vs. Cubs Odds, Run Line, Over/Under & Moneyline

Marlins vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Tuesday‘s MLB game with 72.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Marlins vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Marlins players for Tuesday‘s game, looking at profitable historical betting trends:

Best Marlins Player Prop Bets Today:

• Javier Sanoja has hit the Home Runs Over in 3 of his last 8 away games (+23.50 Units / 294% ROI)
• Javier Sanoja has hit the Total Bases Over in 17 of his last 25 away games (+14.05 Units / 50% ROI)
• Otto Lopez has hit the Hits Under in 19 of his last 25 away games (+12.70 Units / 26% ROI)
• Jakob Marsee has hit the Runs Over in 15 of his last 25 games (+12.50 Units / 50% ROI)
• Jakob Marsee has hit the Walks Over in 9 of his last 15 away games (+9.65 Units / 64% ROI)

And here are some favorite MLB player prop bets for Cubs players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Michael Conforto has hit the Runs Under in 23 of his last 25 games at home (+19.90 Units / 44% ROI)
• Alex Bregman has hit the Home Runs Over in 4 of his last 10 games at home (+17.10 Units / 171% ROI)
• Nico Hoerner has hit the Hits Under in 13 of his last 20 games at home (+11.15 Units / 40% ROI)
• Alex Bregman has hit the Walks Over in 9 of his last 15 games (+9.30 Units / 62% ROI)
• Michael Conforto has hit the Total Bases Under in 17 of his last 25 games at home (+9.15 Units / 31% ROI)

Marlins Best Bets Today:

• The Miami Marlins have hit the Game Total Over in 16 of their last 22 games (+9.50 Units / 39% ROI)
• The Miami Marlins have hit the Team Total Over in 15 of their last 24 games (+4.85 Units / 17% ROI)
• The Miami Marlins have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 19 games (+3.60 Units / 15% ROI)
• The Miami Marlins have covered the Run Line in 6 of their last 8 games (+3.05 Units / 25% ROI)
• The Miami Marlins have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 games (+1.55 Units / 20% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Game Total Over in 26 of their last 40 games (+14.05 Units / 32% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 19 of their last 25 games (+13.05 Units / 45% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 17 of their last 25 games (+12.05 Units / 34% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 13 games at home (+11.15 Units / 73% ROI)
• The Chicago Cubs have covered the Run Line in 27 of their last 50 games (+6.55 Units / 11% ROI)

Marlins Against the Spread (ATS) Record

Against the spread this season, the Marlins are 79-75 against the Run Line (-7.15 Units / -3.45% ROI).

• 76-80 when betting on the Moneyline for -3.1 Units / -1.72% ROI
• 80-72 when betting on the total runs Over for +0.55 Units / 0.32% ROI
• 72-80 when betting on the total runs Under for -15.6 Units / -9.12% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 75-79 against the Run Line (-0.1 Units / -0.06% ROI).

• 87-69 when betting on the Moneyline for -1.25 Units / -0.59% ROI
• 87-65 when betting on the total runs Over for +16.25 Units / 9.45% ROI
• 65-87 when betting on the total runs Under for -30.05 Units / -17.52% ROI

Marlins Keys to the Game vs. the Cubs

The Marlins are just 15-34 (.306) vs the top 10 runs allowed teams this season Today, they face Cubs (12th fewest runs allowed).

The Marlins were just 7-42 (.143) when allowing 2 or more home runs in the 2024 season — lowest in MLB; League Avg: .289.

The Marlins were just 39-14 (.736) when leading entering the 7th inning in the 2024 season — 3rd lowest in MLB; League Avg: .856.

The Marlins are just 31-109 (.221) when allowing 2 or more home runs since the 2024 season — 2nd lowest in MLB.

Cubs Keys to the Game vs. the Marlins

The Cubs are 18-28 (.391) when allowing 10 or more hits this season — best in MLB.

The Cubs are 6-62 (.088) when trailing entering the 9th inning this season — 2nd best in MLB.

The Cubs are 30-35 (.462) when allowing 2 or more home runs this season — best in MLB.

The Cubs are 48-6 (.889) when they’ve had 10 or more hits this season — 2nd best in MLB.

Marlins Hitting Stats & Trends

Marlins hitters have a groundball batting average of .283 this season — best in MLB.

Marlins hitters have a groundball batting average of .307 with runners on base this season — best in MLB.

Marlins hitters have put 39% of their swings in play on the first pitch of at-bats this season — 3rd highest in MLB.

Marlins hitters have an OPS of just .587 (509 PA’s) in lefty-lefty matchups this season — 4th lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .349 (1,636 PA’s) against LHP this season — best in MLB.

Cubs hitters are slugging .448 against LHP this season — best in MLB.

Cubs hitters have an OBP of .340 (6,148 PA’s) this season — 2nd best in MLB.

Cubs hitters have an OPS of .550 (3,223 PA’s) with two-strikes this season — best in MLB.

Marlins Pitching Stats & Trends

The Marlins have won just 12% of road games in which their opponents scored first this season — 3rd lowest in MLB.

Marlins pitchers have picked-off 2 runners from first base this season — fewest in MLB.

Marlins pitchers have thrown at least two strikes in their first three pitches to 66% of opposing batters this season — 5th highest in MLB.

Marlins pitchers have allowed three-ball counts to 19% of batters they faced (1,135/5,860 PA’s) this season — tied for 5th lowest in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .215 against Cubs pitchers with runners on base this season — best in MLB.

Opponents have a groundball batting average of just .223 against Cubs pitchers this season — best in MLB.

Cubs pitchers have won 35% of games in which they have allowed their opponent to score in three different innings this season — tied for 2nd highest in MLB.

Cubs pitchers have allowed an exit velocity over 105 MPH 376 times this season — tied for 3rd most in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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