• The Guardians are -140 favorites vs the Nationals
• Nationals vs Guardians Over / Under today: 7.5 Runs
• Nationals / Guardians TV Channel: GDTV | NATV

The Washington Nationals (+115) visit Progressive Field to take on the Cleveland Guardians (-140) on May 26, 2026. First pitch is scheduled for 6:10 pm in Cleveland, OH.

This season, the Nationals are against the spread (ATS), while the Guardians are ATS.

Nationals vs Guardians Starting Pitchers Today:

• Nationals starting pitcher: Cade Cavalli 2-3, 3.86 ERA
• Guardians starting pitcher: Joey Cantillo 4-1, 3.07 ERA

Nationals vs. Guardians Odds, Run Line, Over/Under & Moneyline

Nationals vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 56.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Nationals vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Nationals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Bets Today:

• Jacob Young has hit the Home Runs Over in 4 of his last 8 games (+45.00 Units / 562% ROI)
• Keibert Ruiz has hit the Singles Under in his last 10 away games (+10.00 Units / 74% ROI)
• Curtis Mead has hit the Runs Over in 12 of his last 20 games (+9.10 Units / 46% ROI)
• James Wood has hit the Walks Over in 14 of his last 20 away games (+8.30 Units / 36% ROI)
• James Wood has hit the Hits Runs and RBIs Under in 14 of his last 20 away games (+7.65 Units / 34% ROI)

And here are some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Angel Martinez has hit the Home Runs Over in 4 of his last 6 games at home (+26.90 Units / 448% ROI)
• Steven Kwan has hit the Hits Under in 14 of his last 20 games (+12.95 Units / 51% ROI)
• Steven Kwan has hit the Walks Over in 8 of his last 10 games at home (+12.35 Units / 124% ROI)
• Steven Kwan has hit the Total Bases Under in 16 of his last 20 games (+11.10 Units / 36% ROI)
• Steven Kwan has hit the Singles Under in 17 of his last 25 games (+10.50 Units / 40% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the Moneyline in 24 of their last 40 away games (+21.55 Units / 54% ROI)
• The Washington Nationals have covered the Run Line in 30 of their last 40 away games (+16.20 Units / 29% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 28 of their last 40 away games (+15.10 Units / 33% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 20 of their last 40 away games (+14.65 Units / 36% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 33 of their last 50 games (+13.00 Units / 21% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the Run Line in 26 of their last 45 games at home (+12.30 Units / 23% ROI)
• The Cleveland Guardians have hit the Moneyline in 14 of their last 18 games (+10.05 Units / 43% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games (+9.35 Units / 16% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 23 of their last 50 games (+7.15 Units / 12% ROI)
• The Cleveland Guardians have hit the Team Total Under in their last 6 games (+6.10 Units / 92% ROI)

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Guardians vs Nationals Home Run Prop Bets Today

Guardians vs Nationals Total Hits Prop Bets Today

Guardians vs Nationals Strikeout Prop Bets Today

Nationals Keys to the Game vs. the Guardians

The Nationals are just 0-23 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .054.

The Nationals are 18-11 (.621) on the road this season — 4th best in MLB; League Avg: .474.

The Nationals are 22-4 (.846) when allowing 4 or fewer runs this season — 4th best in MLB; League Avg: .717.

The Nationals are just 16-52 (.232) when their opponents score in the first inning since the 2025 season — 2nd lowest in MLB; League Avg: .362.

Guardians Keys to the Game vs. the Nationals

The Guardians are 16-7 (.696) after a loss this season — 2nd best in MLB; League Avg: .473.

The Guardians are 10-1 (.909) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .754.

The Guardians are 22-1 (.957) when leading entering the 7th inning this season — 3rd best in MLB; League Avg: .862.

The Guardians are 9-4 (.692) when tied entering the 7th inning this season — 5th best in MLB; League Avg: .500.

Nationals Hitting Stats & Trends

Nationals hitters are slugging .424 against RHP this season — 3rd best in MLB.

The Nationals are batting just .184 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Nationals hitters have 133 extra-base hits out of 320 total hits (42%) against RHP this season — best in MLB.

The Nationals are hitting just .177 against pitchers who have thrown at least 80 pitches in the game this season — 2nd lowest in MLB.

Guardians Hitting Stats & Trends

Guardians hitters are averaging 4.05 pitches per plate appearance this season — highest in MLB.

Guardians hitters have chased 23% of pitches out of the zone in righty-righty matchups this season — lowest in MLB.

Guardians hitters have a groundball batting average of just .196 this season — lowest in MLB.

The Guardians are hitting just .175 against pitchers who have thrown at least 80 pitches in the game this season — lowest in MLB.

Nationals Pitching Stats & Trends

Opponents have a miss rate of just 22% against Nationals pitchers this season — lowest in MLB.

Nationals pitchers have a strikeout rate of just 20% this season — 5th lowest in MLB.

Nationals pitchers have a strikeout rate of just 39% with two-strikes this season — 3rd lowest in MLB.

The Nationals have allowed 6.35 runs per game (165/26) at home this season — highest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have struck out 28% of left-handed batters they faced this season — best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — 2nd best in MLB.

Guardians pitchers have a strikeout rate of 35% in close and late situations this season — best in MLB.

Guardians pitchers have an ERA of 2.69 (127.0 IP) against division opponents this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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