Nationals vs White Sox Prediction, Odds & Player Prop Bets Today – MLB, Apr 24

Chicago White Sox' Kyle Teel, right, is greeted by Lenyn Sosa after he scored on a double by Brooks Baldwin during the first inning of a baseball game against the Washington Nationals, Friday, Sept. 26, 2025, in Washington. (AP Photo/Nick Wass)
(AP Photo/Nick Wass)
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  • The White Sox are -125 favorites vs the Nationals
  • Nationals vs White Sox Over / Under today: 9.5 Runs
  • Nationals / White Sox TV Channel: CHSN | NATV

The Washington Nationals (+105) visit Rate Field to take on the Chicago White Sox (-125) on April 24, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Nationals are 11-15 against the spread (ATS), while the White Sox are 12-13 ATS.

Nationals vs White Sox Starting Pitchers Today:

  • Nationals starting pitcher: Miles Mikolas 0-3, 9.16 ERA
  • White Sox starting pitcher: Bryan Hudson 0-0, 1.69 ERA

Nationals vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Nationals+1.5 -210O 9.5 -120+105
White Sox -1.5 +160U 9.5 +100-125

Nationals vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Friday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Nationals players for Friday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Bets Today:

  • Jacob Young has hit the Home Runs Over in 2 of his last 9 away games (+26.00 Units / 289% ROI)
  • Daylen Lile has hit the Hits Over in 22 of his last 25 away games (+22.55 Units / 51% ROI)
  • Daylen Lile has hit the Singles Over in 22 of his last 25 away games (+18.45 Units / 62% ROI)
  • Daylen Lile has hit the Hits Runs and RBIs Over in 19 of his last 25 away games (+12.85 Units / 44% ROI)
  • Luis Garcia has hit the Total Bases Under in 14 of his last 15 games (+12.30 Units / 48% ROI)

And here are some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

  • Munetaka Murakami has hit the Home Runs Over in 6 of his last 9 games (+19.70 Units / 219% ROI)
  • Colson Montgomery has hit the Singles Under in 13 of his last 15 games (+9.40 Units / 37% ROI)
  • Colson Montgomery has hit the Total Bases Over in his last 6 games (+7.65 Units / 116% ROI)
  • Munetaka Murakami has hit the RBIs Over in 5 of his last 6 games (+7.15 Units / 119% ROI)
  • Munetaka Murakami has hit the Hits Over in 8 of his last 9 games (+6.20 Units / 43% ROI)
  • The Washington Nationals have hit the Moneyline in 15 of their last 25 away games (+15.65 Units / 63% ROI)
  • The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 40 games (+14.90 Units / 30% ROI)
  • The Washington Nationals have hit the Game Total Over in 32 of their last 50 games (+13.35 Units / 24% ROI)
  • The Washington Nationals have hit the Team Total Over in 33 of their last 50 games (+13.30 Units / 22% ROI)
  • The Washington Nationals have covered the Run Line in 14 of their last 18 away games (+9.70 Units / 45% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games at home (+9.65 Units / 17% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 20 of their last 45 games at home (+8.30 Units / 18% ROI)
  • The Chicago White Sox have hit the Game Total Over in 19 of their last 30 games (+6.80 Units / 21% ROI)
  • The Chicago White Sox have hit the Team Total Over in their last 6 games (+6.30 Units / 89% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 30 games (+3.70 Units / 10% ROI)

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 14-11 against the Run Line (+0.45 Units / 1.34% ROI).

  • 11-15 when betting on the Moneyline for +1.75 Units / 6.65% ROI
  • 18-7 when betting on the total runs Over for +10.45 Units / 36.6% ROI
  • 7-18 when betting on the total runs Under for -12.8 Units / -44.6% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 12-13 against the Run Line (-7.55 Units / -20.54% ROI).

  • 10-15 when betting on the Moneyline for -1.3 Units / -5.18% ROI
  • 16-9 when betting on the total runs Over for +6 Units / 21.82% ROI
  • 9-16 when betting on the total runs Under for -8.7 Units / -31.64% ROI

White Sox vs Nationals Home Run Prop Bets Today

Yes
Munetaka Murakami +200
Colson Montgomery +280
James Wood +310
CJ Abrams +425
Miguel Vargas +425

White Sox vs Nationals Total Hits Prop Bets Today

Over Under
Daylen Lile 0.5 -250 0.5 +180
James Wood 0.5 -225 0.5 +165
CJ Abrams 0.5 -220 0.5 +165
Miguel Vargas 0.5 -210 0.5 +155
Colson Montgomery 0.5 -200 0.5 +145

White Sox vs Nationals Strikeout Prop Bets Today

Over Under
Colson Montgomery 0.5 -250 0.5 +180
Everson Pereira 0.5 -235 0.5 +170
Jose Tena 0.5 -150 0.5 +110
Miles Mikolas 3.5 -135 3.5 +100
Jacob Young 0.5 -130 0.5 -105

Nationals Keys to the Game vs. the White Sox

The Nationals are just 8-3 (.727) when leading entering the 8th inning this season — 2nd lowest in MLB; League Avg: .896.

The Nationals were just 11-43 (.200) when their opponents score in the first inning in the 2025 season — lowest in MLB; League Avg: .362.

The Nationals are just 13-48 (.210) when their opponents score in the first inning since the 2025 season — lowest in MLB; League Avg: .364.

The Nationals were just 65-96 (.401) in the 2025 season — 3rd lowest in MLB; League Avg: .500.

White Sox Keys to the Game vs. the Nationals

The White Sox are just 11-106 (.094) when allowing 10 or more hits since the 2024 season — lowest in MLB; League Avg: .251.

The White Sox are just 107-202 (.346) when allowing 5 or more extra base hits since the 2024 season — lowest in MLB; League Avg: .536.

The White Sox were just 55-6 (.902) when leading entering the 9th inning in the 2025 season — lowest in MLB; League Avg: .956.

The White Sox are just 55-18 (.753) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .874.

The Nationals are batting just .167 when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB.

Nationals hitters have an OBP of .290 (541 PA’s) with two-strikes this season — 2nd best in MLB.

The Nationals won only 40% of their home games in the 2025 season — 2nd lowest in MLB.

The Nationals are batting just .235 when facing the starting pitcher for the 3rd time in a game since the 2024 season — 3rd lowest in MLB.

The White Sox won only 33% of their road games in the 2025 season — tied for 2nd lowest in MLB.

The White Sox have won just 47% of games in which they have scored first since the 2024 season — lowest in MLB.

The White Sox have a winning percentage of just 32% since the 2024 season — lowest in MLB.

White Sox hitters have an OPS of just .646 (9,492 PA’s) against RHP since the 2024 season — lowest in MLB.

Nationals pitchers have an ERA of 5.57 (856.1 IP) at home since the 2025 season — 2nd highest in MLB.

Nationals pitchers have an ERA of 5.74 (235.0 IP) this season — 2nd highest in MLB.

The Nationals allowed 1.85 runs per game (299/162) in late innings in the 2025 season — highest in MLB.

Nationals pitchers have an ERA of 6.47 (121.0 IP) at home this season — 2nd highest in MLB.

Opponents have a miss rate of just 22% against White Sox pitchers this season — 2nd lowest in MLB.

White Sox pitchers have walked 10% of batters since the 2025 season — 2nd highest in MLB.

In games when their opponents have scored three or more runs in an inning, the White Sox won just 11% of the time since the 2024 season — lowest in MLB.

The White Sox have won just 15% of games in which their opponents scored first since the 2024 season — lowest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.