Orioles vs Angels Prediction, Odds & Player Prop Bets Today – MLB, Jun 22

Los Angeles Angels' Zach Neto watches his fly out to Oakland Athletics center fielder Lawrence Butler during the first inning of a baseball game, Friday, Sept. 29, 2023, in Anaheim, Calif.
(AP Photo/Ryan Sun)
Sportsbook PromosNew Player Offer
  • The Orioles are -165 favorites vs the Angels
  • Orioles vs Angels Over / Under today: 9 Runs
  • Orioles / Angels TV Channel: MASN | ABTV

The Baltimore Orioles (-165) visit Angel Stadium of Anaheim to take on the Los Angeles Angels (+135) on June 22, 2026. First pitch is scheduled for 9:38 pm in Anaheim, CA.

This season, the Orioles are 37-42 against the spread (ATS), while the Angels are 39-39 ATS.

Orioles vs Angels Starting Pitchers Today:

  • Orioles starting pitcher: Kyle Bradish 4-7, 4.05 ERA
  • Angels starting pitcher: Samuel Aldegheri 2-2, 4.43 ERA

Orioles vs. Angels Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Orioles-1.5 +100O 9 -115-165
Angels +1.5 -120U 9 -105+135

Orioles vs Angels Prediction for Today’s Game

Based on recent trends the model predicts the Orioles will win Monday‘s MLB game with 63.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Orioles vs Angels and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Orioles players for Monday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

  • Kyle Bradish has hit the Walks Allowed Over in 15 of his last 20 games (+11.75 Units / 46% ROI)
  • Blaze Alexander has hit the Home Runs Over in 2 of his last 7 away games (+11.50 Units / 164% ROI)
  • Tyler O’Neill has hit the Runs Under in 13 of his last 15 games (+9.35 Units / 33% ROI)
  • Blaze Alexander has hit the Total Bases Over in 12 of his last 15 games (+9.10 Units / 43% ROI)
  • Blaze Alexander has hit the Hits Over in 12 of his last 15 games (+7.95 Units / 36% ROI)

And here are some favorite MLB player prop bets for Angels players for Monday‘s game, looking at profitable historical betting trends:

Best Angels Player Prop Best Bets Today:

  • Donovan Walton has hit the Home Runs Over in 3 of his last 5 games (+24.50 Units / 490% ROI)
  • Nolan Schanuel has hit the Total Bases Over in 15 of his last 20 games at home (+12.20 Units / 45% ROI)
  • Vaughn Grissom has hit the Hits Under in 10 of his last 15 games at home (+9.95 Units / 54% ROI)
  • Vaughn Grissom has hit the Runs Under in 13 of his last 15 games at home (+9.70 Units / 35% ROI)
  • Zach Neto has hit the RBIs Over in 5 of his last 6 games (+7.85 Units / 131% ROI)
  • The Baltimore Orioles have hit the Team Total Over in 20 of their last 30 games (+8.35 Units / 23% ROI)
  • The Baltimore Orioles have hit the Game Total Over in 19 of their last 30 away games (+8.05 Units / 24% ROI)
  • The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 40 games (+7.85 Units / 18% ROI)
  • The Baltimore Orioles have covered the Run Line in 18 of their last 30 games (+4.50 Units / 11% ROI)
  • The Baltimore Orioles have hit the 1st Five Innings (F5) Moneyline in 4 of their last 7 away games (+4.20 Units / 60% ROI)
  • The Los Angeles Angels have hit the 1st Five Innings (F5) Moneyline in 18 of their last 30 games (+11.70 Units / 34% ROI)
  • The Los Angeles Angels have hit the Team Total Under in 32 of their last 50 games at home (+11.40 Units / 19% ROI)
  • The Los Angeles Angels have covered the 1st Five Innings (F5) Run Line in 21 of their last 30 games (+11.25 Units / 32% ROI)
  • The Los Angeles Angels have covered the Run Line in 12 of their last 17 games (+6.65 Units / 29% ROI)
  • The Los Angeles Angels have hit the Game Total Under in 23 of their last 40 games at home (+5.85 Units / 13% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 39-40 against the Run Line (-4.1 Units / -3.96% ROI).

  • 37-42 when betting on the Moneyline for -7 Units / -7.68% ROI
  • 45-31 when betting on the total runs Over for +10.75 Units / 12.31% ROI
  • 31-45 when betting on the total runs Under for -18.2 Units / -21.04% ROI

Angels Against the Spread (ATS) Record

Against the spread this season, the Angels are 39-39 against the Run Line (-9.1 Units / -8.61% ROI).

  • 32-47 when betting on the Moneyline for -10.2 Units / -12.01% ROI
  • 37-40 when betting on the total runs Over for -6.65 Units / -7.62% ROI
  • 40-37 when betting on the total runs Under for -0.05 Units / -0.06% ROI

Angels vs Orioles Home Run Prop Bets Today

Yes
Pete Alonso +250
Zachary Neto +340
Gunnar Henderson +350
Coby Mayo +350
Samuel Basallo +360

Angels vs Orioles Total Hits Prop Bets Today

Over Under
Gunnar Henderson 0.5 -235 0.5 +175
Pete Alonso 0.5 -210 0.5 +155
Vaughn Grissom 0.5 -200 0.5 +150
Taylor Ward 0.5 -200 0.5 +150
Wade Meckler 0.5 -190 0.5 +140

Angels vs Orioles Strikeout Prop Bets Today

Over Under
Logan O'Hoppe 0.5 -275 0.5 +200
Tyler O'Neill 0.5 -275 0.5 +200
Samuel Basallo 0.5 -235 0.5 +175
Gunnar Henderson 0.5 -235 0.5 +175
Taylor Ward 0.5 -225 0.5 +165

Orioles Keys to the Game vs. the Angels

The Orioles are just 7-34 (.171) when scoring 4 or fewer runs this season — 2nd lowest in MLB; League Avg: .273.

The Orioles are just 18-66 (.214) when allowing 2 or more home runs since the 2025 season — 4th lowest in MLB; League Avg: .299.

The Orioles are just 11-17 (.393) when tied entering the 7th inning since the 2025 season — 4th lowest in MLB; League Avg: .500.

The Orioles are just 6-11 (.353) when tied entering the 8th inning since the 2025 season — 3rd lowest in MLB; League Avg: .500.

Angels Keys to the Game vs. the Orioles

The Angels are just 27-7 (.794) when leading entering the 9th inning this season — lowest in MLB; League Avg: .945.

The Angels are just 12-19 (.387) after a win this season — tied for 2nd lowest in MLB; League Avg: .511.

The Angels are just 3-10 (.231) when tied entering the 7th inning this season — 3rd lowest in MLB; League Avg: .500.

The Angels are just 0-36 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .055.

Orioles hitters are slugging just .233 with two-strikes this season — 4th lowest in MLB.

The Orioles are batting just .228 on the road this season — tied for 4th lowest in MLB.

Orioles hitters have struck out in 25% of their PA’s against LHP this season — 4th highest in MLB.

Orioles hitters are slugging just .468 on the first pitch of at-bats this season — lowest in MLB.

Angels hitters are slugging just .356 at home this season — 2nd lowest in MLB.

Angels hitters have an OPS of just .662 (1,373 PA’s) at home this season — 2nd lowest in MLB.

Angels hitters have struck out in 25% of their PA’s this season — highest in MLB.

Angels hitters have an OPS of .770 (1,639 PA’s) on the road this season — 2nd best in MLB.

Orioles pitchers have an ERA of 5.08 (324.0 IP) on the road this season — 5th highest in MLB.

Orioles pitchers have an ERA of 5.41 (228.0 IP) against division opponents this season — 3rd highest in MLB.

Orioles pitchers have a strikeout rate of just 19% when facing the leadoff batter in the inning this season — 5th lowest in MLB.

The Orioles have allowed 5.32 runs per game (202/38) on the road this season — 4th highest in MLB.

Angels pitchers have walked 12% of batters this season — highest in MLB.

Opponents have a miss rate of 28% against Angels pitchers this season — tied for 2nd best in MLB.

Angels pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Angels pitchers have a first-pitch strike rate of just 58% this season — 2nd lowest in MLB.

More MLB Reading:


Bet now on Orioles vs Angels and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

The content provided in this blog is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of BetMGM LLC. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.

About the Author Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.