• The Orioles are -110 favorites vs the Nationals
• Orioles vs Nationals Over / Under today: 10 Runs
• Orioles / Nationals TV Channel: FS1 | MASN | NATV

The Baltimore Orioles (-110) visit Nationals Park to take on the Washington Nationals (-110) on May 16, 2026. First pitch is scheduled for 4:05 pm in Washington, DC.

This season, the Orioles are 20-25 against the spread (ATS), while the Nationals are 27-17 ATS.

Orioles vs Nationals Starting Pitchers Today:

• Orioles starting pitcher: Chris Bassitt 3-2, 5.22 ERA
• Nationals starting pitcher: Cade Cavalli 1-2, 4.02 ERA

Orioles vs. Nationals Odds, Run Line, Over/Under & Moneyline

Orioles vs Nationals Prediction for Today’s Game

Based on recent trends the model predicts the Nationals will win Saturday‘s MLB game with 51.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Orioles vs Nationals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Orioles players for Saturday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

• Taylor Ward has hit the Walks Over in 20 of his last 25 games (+15.70 Units / 57% ROI)
• Taylor Ward has hit the Total Bases Under in 14 of his last 15 games (+13.65 Units / 55% ROI)
• Jeremiah Jackson has hit the Runs Under in 14 of his last 15 games (+12.20 Units / 38% ROI)
• Colton Cowser has hit the Hits Runs and RBIs Under in 12 of his last 15 away games (+10.40 Units / 58% ROI)
• Pete Alonso has hit the Home Runs Over in 4 of his last 9 away games (+10.10 Units / 112% ROI)

And here are some favorite MLB player prop bets for Nationals players for Saturday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Best Bets Today:

• Daylen Lile has hit the Home Runs Over in 3 of his last 4 games (+18.20 Units / 455% ROI)
• Luis Garcia has hit the Hits Under in 13 of his last 20 games at home (+12.17 Units / 50% ROI)
• Keibert Ruiz has hit the Singles Under in 16 of his last 20 games (+10.35 Units / 37% ROI)
• Curtis Mead has hit the Hits Runs and RBIs Over in 12 of his last 15 games at home (+9.45 Units / 51% ROI)
• Jacob Young has hit the Total Bases Over in 18 of his last 25 games at home (+9.15 Units / 25% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have hit the Game Total Over in 25 of their last 40 away games (+8.75 Units / 20% ROI)
• The Baltimore Orioles have hit the Team Total Under in 7 of their last 8 games (+6.05 Units / 73% ROI)
• The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 6 of their last 7 games (+5.30 Units / 69% ROI)
• The Baltimore Orioles have covered the Run Line in 12 of their last 23 games (+1.90 Units / 7% ROI)
• The Baltimore Orioles have hit the Moneyline in 3 of their last 5 games (+1.30 Units / 24% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 45 games (+17.60 Units / 32% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 19 of their last 25 games (+12.20 Units / 40% ROI)
• The Washington Nationals have hit the Game Total Over in 28 of their last 45 games (+11.80 Units / 24% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 22 of their last 45 games (+9.35 Units / 20% ROI)
• The Washington Nationals have hit the Moneyline in 22 of their last 45 games (+7.25 Units / 16% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 20-25 against the Run Line (-6.1 Units / -10.69% ROI).

• 20-25 when betting on the Moneyline for -8.15 Units / -15.21% ROI
• 26-19 when betting on the total runs Over for +4.9 Units / 9.83% ROI
• 19-26 when betting on the total runs Under for -9.45 Units / -19.21% ROI

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 27-17 against the Run Line (+5.25 Units / 8.45% ROI).

• 22-23 when betting on the Moneyline for +7.25 Units / 15.9% ROI
• 28-15 when betting on the total runs Over for +11.8 Units / 23.86% ROI
• 15-28 when betting on the total runs Under for -15.7 Units / -31.65% ROI

Nationals vs Orioles Home Run Prop Bets Today

Nationals vs Orioles Total Hits Prop Bets Today

Nationals vs Orioles Strikeout Prop Bets Today

Orioles Keys to the Game vs. the Nationals

The Orioles are just 5-21 (.192) when scoring 4 or fewer runs this season — 3rd lowest in MLB; League Avg: .280.

The Orioles are 6-1 (.857) when they’ve scored in the first inning this season — 2nd best in MLB; League Avg: .628.

The Orioles are just 2-98 (.020) when trailing entering the 9th inning since the 2025 season — tied for 3rd lowest in MLB; League Avg: .045.

The Orioles are just 6-10 (.375) when tied entering the 8th inning since the 2025 season — 5th lowest in MLB; League Avg: .500.

Nationals Keys to the Game vs. the Orioles

The Nationals are 17-3 (.850) when allowing 4 or fewer runs this season — 3rd best in MLB; League Avg: .720.

The Nationals are just 15-5 (.750) when leading entering the 7th inning this season — tied for 3rd lowest in MLB; League Avg: .866.

The Nationals are just 7-13 (.350) at home this season — lowest in MLB; League Avg: .541.

The Nationals are just 0-21 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

Orioles Hitting Stats & Trends

The Orioles are batting just .148 with two-strikes this season — 2nd lowest in MLB.

Orioles hitters are slugging just .379 on the first pitch of at-bats this season — 2nd lowest in MLB.

Orioles hitters have an OPS of just .451 (917 PA’s) with two-strikes this season — 3rd lowest in MLB.

The Orioles are batting just .258 on the first pitch of at-bats this season — lowest in MLB.

Nationals Hitting Stats & Trends

The Nationals are batting .268 against LHP this season — 2nd best in MLB.

The Nationals have scored 1.93 runs per game (87/45) in late innings this season — best in MLB.

Nationals hitters are slugging .424 against LHP this season — 5th best in MLB.

Nationals hitters have an OBP of just .271 (214 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd lowest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers have an ERA of 7.01 (86.0 IP) against division opponents this season — highest in MLB.

Opponents are hitting .259 against Orioles pitchers this season — tied for 3rd highest in MLB.

Orioles pitchers have an ERA of 5.19 (180.1 IP) on the road this season — 4th highest in MLB.

The Orioles have allowed 5.18 runs per game (233/45) this season — tied for 3rd highest in MLB.

Nationals Pitching Stats & Trends

Opponents have a miss rate of just 22% against Nationals pitchers this season — tied for lowest in MLB.

Nationals pitchers have a strikeout rate of just 19% this season — 2nd lowest in MLB.

Nationals pitchers have a strikeout rate of just 37% with two-strikes this season — tied for lowest in MLB.

Nationals pitchers have a strikeout rate of just 19% with runners in scoring position this season — 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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