• The Red Sox are -145 favorites vs the Orioles
• Orioles vs Red Sox Over / Under today: 9 Runs
• Orioles / Red Sox TV Channel: NESN | MASN

The Baltimore Orioles (+120) visit Fenway Park to take on the Boston Red Sox (-145) on July 22, 2026. First pitch is scheduled for 1:35 pm in Boston, MA.

This season, the Orioles are 49-52 against the spread (ATS), while the Red Sox are 47-48 ATS.

Orioles vs Red Sox Starting Pitchers Today:

• Orioles starting pitcher: Dean Kremer 1-2, 4.21 ERA
• Red Sox starting pitcher: Jake Bennett 5-3, 2.35 ERA

Orioles vs. Red Sox Odds, Run Line, Over/Under & Moneyline

Orioles vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Wednesday‘s MLB game with 57.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Orioles vs Red Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Orioles players for Wednesday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

• Colton Cowser has hit the Singles Over in 13 of his last 25 away games (+10.20 Units / 41% ROI)
• Taylor Ward has hit the Walks Over in 9 of his last 10 games (+9.30 Units / 90% ROI)
• Jeremiah Jackson has hit the Hits Over in 16 of his last 20 away games (+9.15 Units / 25% ROI)
• Jeremiah Jackson has hit the Singles Over in 14 of his last 20 away games (+9.06 Units / 44% ROI)
• Taylor Ward has hit the Runs Over in 16 of his last 25 away games (+8.80 Units / 34% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

• Masataka Yoshida has hit the Home Runs Over in 3 of his last 9 games (+18.50 Units / 206% ROI)
• Jarren Duran has hit the Total Bases Under in 19 of his last 25 games (+13.75 Units / 43% ROI)
• Jarren Duran has hit the Hits Under in 16 of his last 25 games (+12.60 Units / 46% ROI)
• Ceddanne Rafaela has hit the Hits Runs and RBIs Over in 13 of his last 15 games (+10.55 Units / 54% ROI)
• Jake Bennett has hit the Pitching Outs Over in his last 9 games (+9.45 Units / 81% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have covered the Run Line in 29 of their last 50 games (+8.90 Units / 14% ROI)
• The Baltimore Orioles have hit the Moneyline in 7 of their last 8 games (+6.05 Units / 60% ROI)
• The Baltimore Orioles have hit the Game Total Under in 10 of their last 14 games (+5.80 Units / 38% ROI)
• The Baltimore Orioles have hit the 1st Five Innings (F5) Moneyline in 10 of their last 17 away games (+5.60 Units / 29% ROI)
• The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 23 of their last 40 games (+5.35 Units / 12% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the Moneyline in 19 of their last 21 games (+16.80 Units / 64% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 19 of their last 23 games (+15.75 Units / 52% ROI)
• The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 19 of their last 23 games (+15.60 Units / 58% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Over in 19 of their last 23 games (+15.25 Units / 55% ROI)
• The Boston Red Sox have covered the Run Line in 15 of their last 21 games (+13.70 Units / 54% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 51-49 against the Run Line (+0.45 Units / 0.35% ROI).

• 49-52 when betting on the Moneyline for -7.8 Units / -6.5% ROI
• 53-45 when betting on the total runs Over for +3.4 Units / 3.05% ROI
• 45-53 when betting on the total runs Under for -13 Units / -11.74% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 47-48 against the Run Line (-0.3 Units / -0.24% ROI).

• 51-48 when betting on the Moneyline for -7 Units / -5.73% ROI
• 45-50 when betting on the total runs Over for -10.6 Units / -9.68% ROI
• 50-45 when betting on the total runs Under for +0.4 Units / 0.37% ROI

Red Sox vs Orioles Home Run Prop Bets Today

Red Sox vs Orioles Total Hits Prop Bets Today

Red Sox vs Orioles Strikeout Prop Bets Today

Orioles Keys to the Game vs. the Red Sox

The Orioles are just 2-4 (.333) when tied entering the 8th inning this season — 4th lowest in MLB; League Avg: .500.

The Orioles are just 3-7 (.300) when tied entering the 7th inning this season — 5th lowest in MLB; League Avg: .500.

The Orioles are just 2-4 (.333) when tied entering the 8th inning since the 2025 season — 4th lowest in MLB; League Avg: .500.

The Orioles are just 3-7 (.300) when tied entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .500.

Red Sox Keys to the Game vs. the Orioles

The Red Sox are just 2-7 (.222) when tied entering the 8th inning this season — lowest in MLB; League Avg: .500.

The Red Sox are just 22-27 (.449) at home this season — 5th lowest in MLB; League Avg: .524.

The Red Sox are just 1-43 (.023) when trailing entering the 9th inning this season — tied for 4th lowest in MLB; League Avg: .053.

The Red Sox are 47-1 (.979) when leading entering the 8th inning this season — 2nd best in MLB; League Avg: .903.

Orioles Hitting Stats & Trends

The Orioles are batting just .225 on the road this season — 3rd lowest in MLB.

Orioles hitters have struck out in 24% of their PA’s against RHP this season — 3rd highest in MLB.

Orioles hitters have an OPS of just .474 (2,077 PA’s) with two-strikes this season — 3rd lowest in MLB.

Orioles hitters have a Hard-Hit Rate of 43% this season — tied for best in MLB.

Red Sox Hitting Stats & Trends

Red Sox hitters have an OBP of .338 (1,003 PA’s) against LHP this season — 3rd best in MLB.

Red Sox hitters have an OPS of .775 (1,003 PA’s) against LHP this season — 3rd best in MLB.

Red Sox hitters are slugging just .378 against RHP this season — 2nd lowest in MLB.

Red Sox hitters have an OPS of just .685 (2,706 PA’s) against RHP this season — 2nd lowest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers have an ERA of 5.38 (236.0 IP) against division opponents this season — 3rd highest in MLB.

The Orioles pitchers have allowed their opponents to score first in 52% of their games on the road this season — 4th highest in MLB.

Orioles pitchers have allowed a run 35% of the time after their offense scores this season — tied for 4th highest in MLB.

Orioles pitchers are throwing just 3.82 pitches per plate appearance this season — 5th lowest in MLB.

Red Sox Pitching Stats & Trends

In games when their opponents have scored three or more runs in an inning, the Red Sox won just 9% of the time this season — lowest in MLB.

Red Sox pitchers have an ERA of 3.41 (433.1 IP) on the road this season — tied for 2nd best in MLB.

Red Sox pitchers have allowed innings of 3+ runs in 4% of innings played this season — 2nd lowest in MLB.

The Red Sox have allowed 3.56 runs per game (178/50) on the road this season — 3rd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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