Orioles vs Royals Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

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  • The Royals are -140 favorites vs the Orioles
  • Orioles vs Royals Over / Under today: 9 Runs
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The Baltimore Orioles (+115) visit Kauffman Stadium to take on the Kansas City Royals (-140) on April 21, 2026. First pitch is scheduled for 7:40 pm in Kansas City, MO.

This season, the Orioles are 11-12 against the spread (ATS), while the Royals are 9-13 ATS.

Orioles vs Royals Starting Pitchers Today:

  • Orioles starting pitcher: Shane Baz 0-2, 4.64 ERA
  • Royals starting pitcher: Kris Bubic 2-1, 4.03 ERA

Orioles vs. Royals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Orioles+1.5 -190O 9 -102+115
Royals -1.5 +155U 9 -118-140

Orioles vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Royals will win Tuesday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Orioles players for Tuesday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

  • Jeremiah Jackson has hit the Home Runs Over in 4 of his last 10 games (+27.50 Units / 275% ROI)
  • Shane Baz has hit the Walks Allowed Over in his last 10 away games (+10.40 Units / 69% ROI)
  • Leody Taveras has hit the Runs Over in 7 of his last 8 games (+10.20 Units / 127% ROI)
  • Gunnar Henderson has hit the Hits Under in 16 of his last 25 games (+10.00 Units / 24% ROI)
  • Pete Alonso has hit the Walks Over in 13 of his last 25 games (+9.45 Units / 38% ROI)

And here are some favorite MLB player prop bets for Royals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

  • Bobby Witt Jr. has hit the Runs Under in 23 of his last 25 games (+20.95 Units / 66% ROI)
  • Salvador Perez has hit the RBIs Under in 22 of his last 25 games (+16.00 Units / 33% ROI)
  • Salvador Perez has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+14.85 Units / 49% ROI)
  • Salvador Perez has hit the Hits Under in 16 of his last 25 games (+14.20 Units / 46% ROI)
  • Kyle Isbel has hit the Home Runs Over in 2 of his last 10 games at home (+13.00 Units / 130% ROI)
  • The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 28 of their last 45 games (+9.30 Units / 17% ROI)
  • The Baltimore Orioles have hit the Team Total Under in 27 of their last 45 games (+6.40 Units / 12% ROI)
  • The Baltimore Orioles have hit the Game Total Under in 26 of their last 45 games (+6.05 Units / 12% ROI)
  • The Baltimore Orioles have hit the Moneyline in 24 of their last 50 away games (+3.30 Units / 6% ROI)
  • The Baltimore Orioles have covered the Run Line in 7 of their last 13 games (+0.65 Units / 4% ROI)
  • The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 23 games (+11.15 Units / 42% ROI)
  • The Kansas City Royals have hit the Team Total Under in 30 of their last 50 games (+8.55 Units / 15% ROI)
  • The Kansas City Royals have hit the Game Total Under in 30 of their last 50 games (+8.30 Units / 15% ROI)
  • The Kansas City Royals have hit the Moneyline in 29 of their last 50 games at home (+3.35 Units / 5% ROI)
  • The Kansas City Royals have covered the 1st Five Innings (F5) Run Line in 4 of their last 5 games at home (+2.75 Units / 41% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 9-14 against the Run Line (-6.6 Units / -22.84% ROI).

  • 11-12 when betting on the Moneyline for -3.3 Units / -11.56% ROI
  • 13-10 when betting on the total runs Over for +1.95 Units / 7.72% ROI
  • 10-13 when betting on the total runs Under for -4.4 Units / -17.32% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 9-13 against the Run Line (-7.75 Units / -23.96% ROI).

  • 7-16 when betting on the Moneyline for -11.55 Units / -40.6% ROI
  • 8-15 when betting on the total runs Over for -8.55 Units / -33.53% ROI
  • 15-8 when betting on the total runs Under for +6.35 Units / 25.3% ROI

Royals vs Orioles Home Run Prop Bets Today

Yes
Vinnie Pasquantino +340
Salvador Perez +350
Bobby Witt Jr. +400
Gunnar Henderson +425
Carter Jensen +450

Royals vs Orioles Total Hits Prop Bets Today

Over Under
Maikel Garcia 0.5 -275 0.5 +195
Jeremiah Jackson 0.5 -275 0.5 +190
Gunnar Henderson 0.5 -235 0.5 +175
Vinnie Pasquantino 0.5 -225 0.5 +165
Taylor Ward 0.5 -225 0.5 +165

Royals vs Orioles Strikeout Prop Bets Today

Over Under
Taylor Ward 0.5 -275 0.5 +195
Gunnar Henderson 0.5 -250 0.5 +180
Jac Caglianone 0.5 -235 0.5 +170
Isaac Collins 0.5 -210 0.5 +155
Salvador Perez 0.5 -190 0.5 +140

Orioles Keys to the Game vs. the Royals

The Orioles were just 10-67 (.130) when they allowed 5 or more runs in the 2025 season — 4th lowest in MLB; League Avg: .202.

The Orioles were just 12-51 (.190) when allowing 10 or more hits in the 2025 season — 5th lowest in MLB; League Avg: .256.

The Orioles were 65-20 (.765) when they allowed 4 or fewer runs in the 2025 season — 5th best in MLB; League Avg: .714.

The Orioles are just 6-10 (.375) when tied entering the 8th inning since the 2025 season — 5th lowest in MLB; League Avg: .500.

Royals Keys to the Game vs. the Orioles

The Royals are just 7-4 (.636) when leading entering the 8th inning this season — lowest in MLB; League Avg: .893.

The Royals were 73-0 (1.000) when leading entering the 9th inning in the 2025 season — best in MLB; League Avg: .956.

The Royals are just 1-11 (.083) when allowing 5 or more runs this season — lowest in MLB; League Avg: .233.

The Royals are just 0-10 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .107.

The Orioles are batting just .129 with two-strikes this season — lowest in MLB.

Orioles hitters have struck out in 25% of their PA’s against RHP this season — 3rd highest in MLB.

The Orioles are batting just .196 on the road this season — 3rd lowest in MLB.

Orioles hitters have an OBP of just .308 (5,004 PA’s) against RHP since the 2025 season — 5th lowest in MLB.

Royals hitters struck out in just 17% of their PA’s against RHP in the 2025 season — best in MLB.

Royals hitters struck out in just 18% of their PA’s in the 2025 season — 2nd best in MLB.

Royals hitters are slugging just .170 with two-strikes this season — lowest in MLB.

Royals hitters have struck out in just 19% of their PA’s since the 2025 season — 2nd best in MLB.

Orioles pitchers walked 10% of batters when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

Orioles pitchers have walked 10% of batters when facing the leadoff batter in the inning since the 2025 season — 2nd highest in MLB.

Opponents have a miss rate of 28% against Orioles pitchers this season — 4th best in MLB.

Orioles pitchers allowed an OBP of .352 (1,434 PA’s) when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

Royals pitchers have walked 21% of batters when facing the leadoff batter in the inning over the past seven days (7 games) — highest in MLB.

Opponents have a groundball rate of just 39% against Royals pitchers this season — 2nd lowest in MLB.

Royals pitchers have walked 15% of batters over the past seven days (7 games) — highest in MLB.

Royals pitchers have walked 15% of batters when facing the leadoff batter in the inning this month (19 games) — highest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.