• The Royals are -130 favorites vs the Orioles
• Orioles vs Royals Over / Under today: 9.5 Runs
• Orioles / Royals TV Channel: RYTV | MASN | ESUN

The Baltimore Orioles (+110) visit Kauffman Stadium to take on the Kansas City Royals (-130) on April 22, 2026. First pitch is scheduled for 2:10 pm in Kansas City, MO.

This season, the Orioles are 11-13 against the spread (ATS), while the Royals are 9-14 ATS.

Orioles vs Royals Starting Pitchers Today:

• Orioles starting pitcher: Chris Bassitt 0-2, 6.07 ERA
• Royals starting pitcher: Michael Wacha 2-0, 1.00 ERA

Orioles vs. Royals Odds, Run Line, Over/Under & Moneyline

Orioles vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Royals will win Wednesday‘s MLB game with 53.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Orioles players for Wednesday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

• Leody Taveras has hit the Home Runs Over in 2 of his last 4 games (+17.00 Units / 425% ROI)
• Colton Cowser has hit the Hits Runs and RBIs Under in his last 10 away games (+11.25 Units / 90% ROI)
• Pete Alonso has hit the RBIs Under in 20 of his last 25 away games (+10.30 Units / 21% ROI)
• Colton Cowser has hit the Runs Under in his last 10 away games (+10.00 Units / 48% ROI)
• Colton Cowser has hit the Singles Under in his last 10 away games (+10.00 Units / 48% ROI)

And here are some favorite MLB player prop bets for Royals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

• Bobby Witt Jr. has hit the Runs Under in 23 of his last 25 games (+20.90 Units / 65% ROI)
• Salvador Perez has hit the RBIs Under in 22 of his last 25 games (+16.00 Units / 33% ROI)
• Salvador Perez has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+14.70 Units / 49% ROI)
• Michael Massey has hit the Home Runs Over in 2 of his last 7 games at home (+13.50 Units / 193% ROI)
• Salvador Perez has hit the Hits Under in 15 of his last 25 games (+11.25 Units / 36% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 27 of their last 45 games (+7.30 Units / 13% ROI)
• The Baltimore Orioles have hit the Team Total Over in 10 of their last 14 games (+5.90 Units / 39% ROI)
• The Baltimore Orioles have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)
• The Baltimore Orioles have hit the Moneyline in 17 of their last 35 away games (+2.00 Units / 5% ROI)
• The Baltimore Orioles have covered the Run Line in 8 of their last 14 games (+1.65 Units / 9% ROI)

Royals Best Bets Today:

• The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 24 games (+9.90 Units / 36% ROI)
• The Kansas City Royals have hit the Team Total Under in 29 of their last 50 games (+6.30 Units / 11% ROI)
• The Kansas City Royals have hit the Game Total Under in 29 of their last 50 games (+6.20 Units / 11% ROI)
• The Kansas City Royals have hit the 1st Five Innings (F5) Moneyline in 4 of their last 5 games at home (+4.00 Units / 47% ROI)
• The Kansas City Royals have hit the Moneyline in 29 of their last 50 games at home (+3.00 Units / 5% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 10-14 against the Run Line (-5.6 Units / -18.21% ROI).

• 11-13 when betting on the Moneyline for -4.3 Units / -14.55% ROI
• 14-10 when betting on the total runs Over for +2.95 Units / 11.2% ROI
• 10-14 when betting on the total runs Under for -5.5 Units / -20.75% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 9-14 against the Run Line (-8.75 Units / -26.24% ROI).

• 8-16 when betting on the Moneyline for -10.55 Units / -35.46% ROI
• 9-15 when betting on the total runs Over for -7.55 Units / -28.38% ROI
• 15-9 when betting on the total runs Under for +5.25 Units / 20.04% ROI

Royals vs Orioles Home Run Prop Bets Today

Royals vs Orioles Total Hits Prop Bets Today

Royals vs Orioles Strikeout Prop Bets Today

Orioles Keys to the Game vs. the Royals

The Orioles were just 12-51 (.190) when allowing 10 or more hits in the 2025 season — 5th lowest in MLB; League Avg: .256.

The Orioles were just 63-10 (.863) when leading entering the 8th inning in the 2025 season — 5th lowest in MLB; League Avg: .909.

The Orioles are just 6-10 (.375) when tied entering the 8th inning since the 2025 season — tied for 4th lowest in MLB; League Avg: .500.

The Orioles are just 2-87 (.022) when trailing entering the 9th inning since the 2025 season — tied for 4th lowest in MLB; League Avg: .044.

Royals Keys to the Game vs. the Orioles

The Royals are just 8-4 (.667) when leading entering the 8th inning this season — lowest in MLB; League Avg: .895.

The Royals are just 0-10 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .105.

The Royals are just 8-12 (.400) when allowing 5 or more extra base hits this season — tied for 4th lowest in MLB; League Avg: .525.

The Royals were 73-0 (1.000) when leading entering the 9th inning in the 2025 season — best in MLB; League Avg: .956.

Orioles Hitting Stats & Trends

The Orioles are batting just .232 on the first pitch of at-bats this season — lowest in MLB.

Orioles hitters are slugging just .303 on the first pitch of at-bats this season — lowest in MLB.

The Orioles are batting just .135 with two-strikes this season — 2nd lowest in MLB.

Orioles hitters are slugging just .190 with two-strikes this season — lowest in MLB.

Royals Hitting Stats & Trends

Royals hitters struck out in just 17% of their PA’s against RHP in the 2025 season — best in MLB.

Royals hitters struck out in just 18% of their PA’s in the 2025 season — 2nd best in MLB.

Royals hitters had an OPS of just .892 (1,140 PA’s) when the pitcher was behind in the count in the 2025 season — lowest in MLB.

Royals hitters put 40% of their swings in play on the first pitch of at-bats in the 2025 season — highest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers walked 10% of batters when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

Orioles pitchers have walked 10% of batters when facing the leadoff batter in the inning since the 2025 season — 2nd highest in MLB.

Opponents have a miss rate of 29% against Orioles pitchers this season — tied for 3rd best in MLB.

In games when their opponents scored three or more runs in an inning, the Orioles won just 11% of the time in the 2025 season — lowest in MLB.

Royals Pitching Stats & Trends

Royals pitchers have walked 21% of batters when facing the leadoff batter in the inning over the past seven days (7 games) — highest in MLB.

Royals pitchers have walked 15% of batters over the past seven days (7 games) — highest in MLB.

Opponents have a groundball rate of just 39% against Royals pitchers this season — tied for 3rd lowest in MLB.

Royals pitchers have walked 12% of batters this season — tied for 4th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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