• The Padres are -102 favorites vs the Cardinals
• Padres vs Cardinals Over / Under today: 8 Runs
• Padres / Cardinals TV Channel: CATV | PDTV | TBS

The San Diego Padres (-102) visit Busch Stadium to take on the St. Louis Cardinals (-118) on June 16, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Padres are 37-34 against the spread (ATS), while the Cardinals are 44-25 ATS.

Padres vs Cardinals Starting Pitchers Today:

• Padres starting pitcher: Michael King 4-5, 3.45 ERA
• Cardinals starting pitcher: Andre Pallante 7-4, 3.86 ERA

Padres vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Padres vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Manny Machado has hit the Singles Under in 20 of his last 25 games (+13.45 Units / 41% ROI)
• Xander Bogaerts has hit the Hits Under in 14 of his last 20 away games (+13.00 Units / 51% ROI)
• Rodolfo Duran has hit the Home Runs Over in 2 of his last 5 away games (+11.90 Units / 238% ROI)
• Xander Bogaerts has hit the Total Bases Under in 19 of his last 25 away games (+11.70 Units / 32% ROI)
• Will Wagner has hit the Runs Under in his last 10 games (+10.00 Units / 48% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Alec Burleson has hit the Home Runs Over in 6 of his last 10 games (+20.60 Units / 206% ROI)
• Alec Burleson has hit the RBIs Over in 11 of his last 15 games (+13.50 Units / 90% ROI)
• Alec Burleson has hit the Hits Runs and RBIs Over in 13 of his last 15 games (+11.30 Units / 61% ROI)
• Lars Nootbaar has hit the Walks Under in 19 of his last 25 games at home (+9.80 Units / 23% ROI)
• Jordan Walker has hit the Hits Over in 9 of his last 10 games (+9.45 Units / 51% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 32 of their last 50 games (+11.90 Units / 20% ROI)
• The San Diego Padres have hit the Game Total Under in 24 of their last 40 games (+6.50 Units / 15% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 18 of their last 30 away games (+4.20 Units / 11% ROI)
• The San Diego Padres have hit the Moneyline in 19 of their last 35 away games (+3.75 Units / 10% ROI)
• The San Diego Padres have covered the Run Line in 13 of their last 22 away games (+2.40 Units / 8% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 33 of their last 50 games (+13.25 Units / 22% ROI)
• The St. Louis Cardinals have covered the Run Line in 30 of their last 45 games (+11.15 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 14 games (+10.15 Units / 59% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+9.80 Units / 18% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 11 of their last 14 games (+8.00 Units / 48% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 36-33 against the Run Line (-1.8 Units / -1.89% ROI).

• 37-34 when betting on the Moneyline for +0 Units / 0% ROI
• 31-38 when betting on the total runs Over for -10.85 Units / -13.81% ROI
• 38-31 when betting on the total runs Under for +4.15 Units / 5.33% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 44-25 against the Run Line (+10.7 Units / 10.51% ROI).

• 39-31 when betting on the Moneyline for +12.6 Units / 17.07% ROI
• 31-35 when betting on the total runs Over for -7.25 Units / -9.46% ROI
• 35-31 when betting on the total runs Under for +0.7 Units / 0.9% ROI

Padres Keys to the Game vs. the Cardinals

The Padres are 23-1 (.958) when scoring 5 or more runs this season — best in MLB; League Avg: .793.

The Padres are 8-3 (.727) when tied entering the 7th inning this season — 3rd best in MLB; League Avg: .500.

The Padres are 4-32 (.111) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .056.

The Padres are 28-1 (.966) when leading entering the 8th inning this season — 5th best in MLB; League Avg: .894.

Cardinals Keys to the Game vs. the Padres

The Cardinals are 3-27 (.100) when trailing entering the 9th inning this season — tied for 5th best in MLB; League Avg: .056.

The Cardinals are 16-5 (.762) when they’ve scored in the first inning this season — tied for 4th best in MLB; League Avg: .646.

The Cardinals are 12-92 (.115) when trailing entering the 8th inning since the 2025 season — tied for 5th best in MLB; League Avg: .095.

The Cardinals are 32-20 (.615) when tied entering the 7th inning since the 2024 season — 4th best in MLB; League Avg: .499.

Padres Hitting Stats & Trends

Padres hitters have an OPS of just .652 (2,586 PA’s) this season — lowest in MLB.

Padres hitters have an OPS of just .637 (1,357 PA’s) at home this season — lowest in MLB.

Padres hitters have an OPS of just .607 (1,538 PA’s) with bases empty this season — lowest in MLB.

Padres hitters have an OBP of just .284 (624 PA’s) against LHP this season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

Cardinals hitters are slugging .258 on pitches out of the zone this season — 4th best in MLB.

Cardinals hitters have 99 extra-base hits out of 335 total hits (just 30%) against starting pitchers this season — lowest in MLB.

Cardinals hitters have put 44% of their swings in play in lefty-lefty matchups this season — highest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 46% against Padres pitchers this season — 3rd highest in MLB.

Padres pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 3rd highest in MLB.

Opponents have a groundball batting average of .296 against Padres pitchers with runners on base this season — 3rd highest in MLB.

The longest HR allowed by the Padres pitchers this season traveled 433.8 feet — — shortest in MLB

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 19% with runners in scoring position this season — lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 4th highest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 90.2 MPH this season (1,818 balls in play) — highest in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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