• The Padres are -130 favorites vs the Diamondbacks
• Padres vs Diamondbacks Over / Under today: 9.5 Runs
• Padres / Diamondbacks TV Channel: DBTV | PDTV

The San Diego Padres (-130) visit Chase Field to take on the Arizona Diamondbacks (+105) on August 5, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the Padres are 59-55 against the spread (ATS), while the Diamondbacks are 60-50 ATS.

Padres vs Diamondbacks Starting Pitchers Today:

• Padres starting pitcher: Casey Mize 4-6, 2.70 ERA
• Diamondbacks starting pitcher: Mitch Bratt 0-1, 5.15 ERA

Padres vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

Padres vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Wednesday‘s MLB game with 52.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Diamondbacks and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Jackson Merrill has hit the Home Runs Over in 4 of his last 9 away games (+16.50 Units / 183% ROI)
• Jackson Merrill has hit the RBIs Over in 14 of his last 25 games (+13.25 Units / 53% ROI)
• Ty France has hit the Hits Runs and RBIs Over in 16 of his last 20 games (+11.60 Units / 47% ROI)
• Ty France has hit the Total Bases Over in 14 of his last 20 games (+10.90 Units / 47% ROI)
• Ty France has hit the Runs Over in 13 of his last 20 games (+10.50 Units / 52% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• James McCann has hit the Home Runs Over in 3 of his last 8 games (+21.00 Units / 262% ROI)
• Ildemaro Vargas has hit the Total Bases Under in 16 of his last 20 games at home (+11.00 Units / 35% ROI)
• Nolan Arenado has hit the Singles Under in 19 of his last 25 games (+10.75 Units / 30% ROI)
• Ildemaro Vargas has hit the Hits Under in 12 of his last 20 games at home (+10.35 Units / 45% ROI)
• James McCann has hit the Hits Runs and RBIs Over in his last 8 games (+8.95 Units / 95% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Over in 30 of their last 50 games (+9.05 Units / 16% ROI)
• The San Diego Padres have hit the Moneyline in 9 of their last 11 games (+6.55 Units / 43% ROI)
• The San Diego Padres have covered the Run Line in 8 of their last 10 away games (+6.10 Units / 41% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 9 of their last 14 games (+4.80 Units / 33% ROI)
• The San Diego Padres have hit the Game Total Over in 12 of their last 20 games (+3.05 Units / 14% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Moneyline in 15 of their last 22 games (+11.25 Units / 46% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 32 of their last 50 games at home (+10.25 Units / 17% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 29 of their last 50 games (+9.55 Units / 18% ROI)
• The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 12 of their last 18 games at home (+6.00 Units / 29% ROI)
• The Arizona Diamondbacks have hit the Team Total Over in 21 of their last 35 games at home (+5.25 Units / 13% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 60-52 against the Run Line (+2.1 Units / 1.39% ROI).

• 59-55 when betting on the Moneyline for +0.85 Units / 0.63% ROI
• 52-60 when betting on the total runs Over for -14.05 Units / -11.16% ROI
• 60-52 when betting on the total runs Under for +3.15 Units / 2.52% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 60-50 against the Run Line (+0.95 Units / 0.62% ROI).

• 60-54 when betting on the Moneyline for +7.35 Units / 5.55% ROI
• 48-60 when betting on the total runs Over for -17.9 Units / -14.21% ROI
• 60-48 when betting on the total runs Under for +7.75 Units / 6.2% ROI

Diamondbacks vs Padres Home Run Prop Bets Today

Diamondbacks vs Padres Total Hits Prop Bets Today

Diamondbacks vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Diamondbacks

The Padres are 12-5 (.706) when tied entering the 7th inning this season — 4th best in MLB.

The Padres are 44-1 (.978) when leading entering the 8th inning this season — tied for 3rd best in MLB.

The Padres are 47-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Padres are 12-5 (.706) when tied entering the 7th inning since the 2025 season — 4th best in MLB.

Diamondbacks Keys to the Game vs. the Padres

The Diamondbacks are 53-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks are 26-15 (.634) vs bottom 10 scoring offenses this season Today, they face the Padres (23rd in runs scored).

The Diamondbacks are 26-15 (.634) vs bottom 10 scoring offenses since the 2025 season Today, they face the Padres (23rd in runs scored).

The Diamondbacks are 53-0 (1.000) when leading entering the 9th inning since the 2025 season — tied for best in MLB.

Padres Hitting Stats & Trends

The Padres are batting .378 on the first pitch of at-bats this season — 2nd best in MLB.

Padres hitters are slugging just .355 at home this season — 2nd lowest in MLB.

The Padres are batting .246 with two outs this season — 3rd best in MLB.

Padres hitters have an OPS of just .675 (1,024 PA’s) against LHP this season — 5th lowest in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .279 against LHP this season — best in MLB.

Diamondbacks hitters have an OPS of .788 (1,134 PA’s) against LHP this season — 2nd best in MLB.

Diamondbacks hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

Diamondbacks hitters are slugging .446 against LHP this season — best in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball batting average of .268 against Padres pitchers this season — 4th highest in MLB.

Padres pitchers have allowed an exit velocity over 100 MPH 599 times this season — tied for 4th fewest in MLB.

Padres pitchers have a strikeout rate of just 14% when going through the lineup the third time in a game this season — 2nd lowest in MLB.

Padres pitchers have a strikeout rate of 27% in close and late situations this season — 4th best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 18% with runners in scoring position this season — 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 37% with two-strikes this season — 3rd lowest in MLB.

The Diamondbacks have won 48% of games in which their opponents scored first this season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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