• The Padres are +105 favorites vs the Dodgers
• Padres vs Dodgers Over / Under today: 8 Runs
• Padres / Dodgers TV Channel: SNLA | PDTV | TBS

The San Diego Padres (+105) visit Dodger Stadium to take on the Los Angeles Dodgers (-125) on September 22, 2026. First pitch is scheduled for 10:10 pm in Los Angeles, CA.

This season, the Padres are 87-69 against the spread (ATS), while the Dodgers are 68-87 ATS.

Padres vs Dodgers Starting Pitchers Today:

• Padres starting pitcher: Michael King 12-9, 3.04 ERA
• Dodgers starting pitcher: Undecided 0-0, 0.00 ERA

Padres vs. Dodgers Odds, Run Line, Over/Under & Moneyline

Padres vs Dodgers Prediction for Today’s Game

Based on recent trends the model predicts the Dodgers will win Tuesday‘s MLB game with 52.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Fernando Tatis Jr. has hit the Singles Under in 19 of his last 25 away games (+16.05 Units / 62% ROI)
• Fernando Tatis Jr. has hit the Home Runs Over in 5 of his last 9 games (+14.20 Units / 158% ROI)
• Michael King has hit the Pitching Outs Over in 20 of his last 25 games (+13.85 Units / 44% ROI)
• Manny Machado has hit the Hits Under in 13 of his last 20 away games (+12.45 Units / 54% ROI)
• Luis Campusano has hit the Runs Under in 17 of his last 20 away games (+12.30 Units / 33% ROI)

And here are some favorite MLB player prop bets for Dodgers players for Tuesday‘s game, looking at profitable historical betting trends:

Best Dodgers Player Prop Best Bets Today:

• Kyle Tucker has hit the Home Runs Over in 5 of his last 10 games (+20.30 Units / 203% ROI)
• Teoscar Hernández has hit the Singles Over in 19 of his last 25 games at home (+16.20 Units / 64% ROI)
• Freddie Freeman has hit the Hits Runs and RBIs Under in 16 of his last 20 games at home (+12.50 Units / 58% ROI)
• Kyle Tucker has hit the Total Bases Under in 18 of his last 25 games at home (+12.10 Units / 36% ROI)
• Teoscar Hernández has hit the Hits Over in 17 of his last 20 games at home (+11.65 Units / 30% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Moneyline in 34 of their last 50 games (+13.70 Units / 19% ROI)
• The San Diego Padres have hit the Team Total Over in 32 of their last 50 away games (+12.40 Units / 22% ROI)
• The San Diego Padres have hit the Game Total Over in their last 12 games (+12.00 Units / 90% ROI)
• The San Diego Padres have covered the Run Line in 24 of their last 40 games (+11.15 Units / 22% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 14 games (+10.60 Units / 67% ROI)

Dodgers Best Bets Today:

• The Los Angeles Dodgers have hit the Moneyline in their last 10 games at home (+10.00 Units / 37% ROI)
• The Los Angeles Dodgers have hit the Team Total Under in 24 of their last 40 games at home (+7.30 Units / 16% ROI)
• The Los Angeles Dodgers have hit the 1st Five Innings (F5) Team Total Over in 19 of their last 30 games (+6.80 Units / 19% ROI)
• The Los Angeles Dodgers have covered the Run Line in 10 of their last 14 games (+5.50 Units / 32% ROI)
• The Los Angeles Dodgers have hit the Game Total Over in 14 of their last 23 games at home (+5.30 Units / 21% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 85-68 against the Run Line (+13.45 Units / 6.62% ROI).

• 87-69 when betting on the Moneyline for +11.25 Units / 5.81% ROI
• 74-77 when betting on the total runs Over for -10.7 Units / -6.21% ROI
• 77-74 when betting on the total runs Under for -3.8 Units / -2.22% ROI

Dodgers Against the Spread (ATS) Record

Against the spread this season, the Dodgers are 68-87 against the Run Line (-25.55 Units / -13.83% ROI).

• 96-60 when betting on the Moneyline for -14.85 Units / -4.82% ROI
• 72-80 when betting on the total runs Over for -16.2 Units / -9.42% ROI
• 80-72 when betting on the total runs Under for +0.9 Units / 0.53% ROI

Padres Keys to the Game vs. the Dodgers

The Padres are 62-5 (.925) when leading entering the 7th inning this season — tied for 3rd best in MLB.

The Padres are 62-8 (.886) when scoring 5 or more runs this season — 2nd best in MLB.

The Padres are 13-8 (.619) when tied entering the 7th inning this season — tied for 4th best in MLB.

The Padres are 69-2 (.972) when leading entering the 8th inning this season — tied for 2nd best in MLB.

Dodgers Keys to the Game vs. the Padres

The Dodgers are 26-19 (.578) when their opponents score in the first inning this season — best in MLB.

The Dodgers are 41-16 (.719) vs bottom 10 scoring offenses this season Today, they face the Padres (18th in runs scored).

The Dodgers are 37-50 (.425) when scoring 4 or fewer runs this season — 2nd best in MLB.

The Dodgers are 80-25 (.762) when allowing 4 or fewer runs this season — 5th best in MLB.

Padres Hitting Stats & Trends

Padres hitters are slugging .622 on the first pitch of at-bats this season — 2nd best in MLB.

The Padres have won 94% of home games in which they have scored three or more runs in an inning this season — 2nd highest in MLB.

The Padres have answered-back in 37% of innings after an opponent scores in late innings this season — highest in MLB.

Padres hitters have put just 34% of balls in play to the right side of the field this season — lowest in MLB.

Dodgers Hitting Stats & Trends

Dodgers hitters have an OPS of .779 (3,126 PA’s) on the road this season — best in MLB.

Dodgers hitters have an OBP of .349 (3,126 PA’s) on the road this season — best in MLB.

The Dodgers are batting .265 on the road this season — best in MLB.

Dodgers hitters have a 46% QAB rate this season — tied for best in MLB.

Padres Pitching Stats & Trends

Padres pitchers have an ERA of 3.37 (716.0 IP) at home this season — 3rd best in MLB.

Padres pitchers have a strikeout rate of 29% in close and late situations this season — 2nd best in MLB.

The Padres have allowed 1.08 runs per game (169/156) in late innings this season — 2nd best in MLB.

Padres pitchers have allowed innings of 3+ runs in 4% of innings played this season — tied for 2nd lowest in MLB.

Dodgers Pitching Stats & Trends

Dodgers pitchers have a strikeout rate of 46% with two-strikes this season — tied for 2nd best in MLB.

Opponents are hitting just .219 against Dodgers pitchers this season — best in MLB.

Dodgers pitchers have a strikeout rate of 25% this season — 3rd best in MLB.

Opponents have a miss rate of 28% against Dodgers pitchers this season — tied for 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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