• The Padres are -150 favorites vs the Giants
• Padres vs Giants Over / Under today: 8 Runs
• Padres / Giants TV Channel: NSBA | PDTV | ESUN

The San Diego Padres (-150) visit Oracle Park to take on the San Francisco Giants (+125) on May 4, 2026. First pitch is scheduled for 9:45 pm in San Francisco, CA.

This season, the Padres are 20-13 against the spread (ATS), while the Giants are 14-19 ATS.

Padres vs Giants Starting Pitchers Today:

• Padres starting pitcher: Randy Vasquez 3-0, 2.97 ERA
• Giants starting pitcher: Trevor McDonald 0-0, 0.00 ERA

Padres vs. Giants Odds, Run Line, Over/Under & Moneyline

Padres vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Monday‘s MLB game with 57.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Miguel Andujar has hit the Home Runs Over in 2 of his last 4 games (+13.50 Units / 338% ROI)
• Jackson Merrill has hit the Singles Under in 16 of his last 20 away games (+12.20 Units / 55% ROI)
• Jake Cronenworth has hit the Total Bases Under in 18 of his last 25 games (+10.90 Units / 35% ROI)
• Jake Cronenworth has hit the Hits Under in 16 of his last 25 games (+10.35 Units / 38% ROI)
• Jackson Merrill has hit the Hits Runs and RBIs Under in his last 10 away games (+10.20 Units / 82% ROI)

And here are some favorite MLB player prop bets for Giants players for Monday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Willy Adames has hit the Walks Under in 18 of his last 20 games (+13.30 Units / 32% ROI)
• Luis Arraez has hit the Singles Over in 17 of his last 20 games at home (+11.55 Units / 32% ROI)
• Rafael Devers has hit the Runs Under in 16 of his last 20 games (+10.15 Units / 31% ROI)
• Willy Adames has hit the Hits Runs and RBIs Under in his last 10 games (+10.00 Units / 66% ROI)
• Heliot Ramos has hit the Total Bases Over in 14 of his last 20 games (+9.55 Units / 38% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 21 of their last 30 away games (+10.95 Units / 32% ROI)
• The San Diego Padres have hit the Moneyline in 31 of their last 50 games (+8.85 Units / 13% ROI)
• The San Diego Padres have hit the Game Total Under in 29 of their last 50 away games (+7.35 Units / 13% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 10 away games (+5.75 Units / 47% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 19 of their last 40 games (+5.50 Units / 11% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Over in 23 of their last 35 games at home (+9.55 Units / 23% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 50 games at home (+7.00 Units / 13% ROI)
• The San Francisco Giants have hit the Moneyline in 6 of their last 8 games at home (+5.65 Units / 67% ROI)
• The San Francisco Giants have hit the Game Total Over in 19 of their last 35 games at home (+4.70 Units / 12% ROI)
• The San Francisco Giants have covered the Run Line in 6 of their last 8 games at home (+3.60 Units / 34% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 18-14 against the Run Line (+1.65 Units / 3.71% ROI).

• 20-13 when betting on the Moneyline for +4.95 Units / 11.62% ROI
• 15-16 when betting on the total runs Over for -2.4 Units / -6.61% ROI
• 16-15 when betting on the total runs Under for -0.35 Units / -0.96% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 14-19 against the Run Line (-11.75 Units / -24.2% ROI).

• 13-21 when betting on the Moneyline for -7.6 Units / -20.74% ROI
• 14-17 when betting on the total runs Over for -4.55 Units / -12.2% ROI
• 17-14 when betting on the total runs Under for +1.55 Units / 4.13% ROI

Giants vs Padres Home Run Prop Bets Today

Giants vs Padres Total Hits Prop Bets Today

Giants vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Giants

The Padres are 30-19 (.612) vs the top 10 runs allowed teams since the 2025 season Today, they face Giants (ninth in runs allowed).

The Padres are 15-2 (.882) when allowing 4 or fewer runs this season — tied for 3rd best in MLB; League Avg: .724.

The Padres are 14-66 (.175) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .128.

The Padres are 13-1 (.929) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .779.

Giants Keys to the Game vs. the Padres

The Giants are just 0-16 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .145.

The Giants are just 6-14 (.300) after a loss this season — 2nd lowest in MLB; League Avg: .472.

The Giants are just 9-4 (.692) when leading entering the 7th inning this season — 2nd lowest in MLB; League Avg: .855.

The Giants are just 78-7 (.918) when leading entering the 9th inning since the 2025 season — 2nd lowest in MLB; League Avg: .954.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Padres hitters have an OBP of just .287 (670 PA’s) against starting pitchers this season — lowest in MLB.

Padres hitters have drawn walks in 8% of their PA’s against LHP this season — tied for 4th lowest in MLB.

Padres hitters have struck out in just 20% of their PA’s since the 2025 season — 3rd best in MLB.

Giants Hitting Stats & Trends

Giants hitters have drawn walks in 6% of their PA’s this season — lowest in MLB.

Giants hitters have an OBP of just .283 (2,022 PA’s) against LHP since the 2025 season — lowest in MLB.

Giants hitters have an OBP of just .283 (833 PA’s) against RHP this season — lowest in MLB.

Giants hitters have drawn walks in 5% of their PA’s against RHP this season — lowest in MLB.

Padres Pitching Stats & Trends

Padres pitchers have walked 18% of batters when facing the leadoff batter in the inning over the past seven days (6 games) — highest in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — tied for highest in MLB.

Opponents have a miss rate of 28% against Padres pitchers this season — 2nd best in MLB.

Padres pitchers have a strikeout rate of just 18% over the last 14 days — tied for 3rd lowest in MLB.

Giants Pitching Stats & Trends

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB.

Opponents have a groundball rate of 47% against Giants pitchers this season — 3rd highest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 57% of opposing batters this season — lowest in MLB.

Opponents have a groundball rate of 46% against Giants pitchers since the 2025 season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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