• The Padres are -118 favorites vs the Giants
• Padres vs Giants Over / Under today: 8.5 Runs
• Padres / Giants TV Channel: NSBA | PDTV

The San Diego Padres (-118) visit Oracle Park to take on the San Francisco Giants (-102) on May 6, 2026. First pitch is scheduled for 3:45 pm in San Francisco, CA.

This season, the Padres are 21-14 against the spread (ATS), while the Giants are 15-20 ATS.

Padres vs Giants Starting Pitchers Today:

• Padres starting pitcher: Matt Waldron 0-1, 9.89 ERA
• Giants starting pitcher: Adrian Houser 0-3, 7.13 ERA

Padres vs. Giants Odds, Run Line, Over/Under & Moneyline

Padres vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Wednesday‘s MLB game with 52.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Xander Bogaerts has hit the Home Runs Over in 2 of his last 5 away games (+14.90 Units / 298% ROI)
• Manny Machado has hit the Hits Under in 13 of his last 20 away games (+10.40 Units / 40% ROI)
• Manny Machado has hit the Total Bases Under in 19 of his last 25 away games (+10.35 Units / 28% ROI)
• Jackson Merrill has hit the Singles Under in 17 of his last 25 away games (+9.05 Units / 33% ROI)
• Fernando Tatis Jr. has hit the RBIs Under in 13 of his last 15 games (+8.95 Units / 30% ROI)

And here are some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Casey Schmitt has hit the Home Runs Over in his last 4 games at home (+23.50 Units / 588% ROI)
• Willy Adames has hit the Walks Under in 19 of his last 20 games (+16.35 Units / 38% ROI)
• Rafael Devers has hit the Runs Under in 17 of his last 20 games (+12.60 Units / 38% ROI)
• Heliot Ramos has hit the Total Bases Over in 14 of his last 20 games (+10.00 Units / 40% ROI)
• Willy Adames has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+9.20 Units / 34% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 17 of their last 23 away games (+10.15 Units / 38% ROI)
• The San Diego Padres have hit the Moneyline in 28 of their last 45 games (+8.45 Units / 15% ROI)
• The San Diego Padres have hit the Game Total Under in 29 of their last 50 away games (+7.35 Units / 13% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 22 of their last 45 games (+6.40 Units / 11% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 12 away games (+5.65 Units / 38% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Over in 25 of their last 40 games at home (+8.10 Units / 17% ROI)
• The San Francisco Giants have hit the Game Total Over in 22 of their last 40 games at home (+5.50 Units / 12% ROI)
• The San Francisco Giants have hit the Moneyline in 7 of their last 10 games at home (+5.35 Units / 49% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 19 games at home (+4.40 Units / 21% ROI)
• The San Francisco Giants have covered the Run Line in 7 of their last 10 games at home (+3.60 Units / 28% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 19-15 against the Run Line (+1.65 Units / 3.5% ROI).

• 21-14 when betting on the Moneyline for +4.8 Units / 10.68% ROI
• 16-17 when betting on the total runs Over for -2.5 Units / -6.49% ROI
• 17-16 when betting on the total runs Under for -0.45 Units / -1.17% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 15-20 against the Run Line (-11.75 Units / -23.02% ROI).

• 14-22 when betting on the Moneyline for -7.9 Units / -20.2% ROI
• 15-18 when betting on the total runs Over for -4.65 Units / -11.77% ROI
• 18-15 when betting on the total runs Under for +1.45 Units / 3.65% ROI

Giants vs Padres Home Run Prop Bets Today

Giants vs Padres Total Hits Prop Bets Today

Giants vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Giants

The Padres are 78-7 (.918) when leading entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .872.

The Padres are 10-6 (.625) on the road this season — 5th best in MLB; League Avg: .463.

The Padres are 31-20 (.608) vs the top 10 runs allowed teams since the 2025 season Today, they face Giants (eighth in runs allowed).

The Padres are 14-1 (.933) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .784.

Giants Keys to the Game vs. the Padres

The Giants are 41-10 (.804) when they’ve hit 2 or more home runs since the 2025 season — best in MLB; League Avg: .699.

The Giants are just 0-18 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .110.

The Giants are just 14-22 (.389) this season — tied for 3rd lowest in MLB; League Avg: .500.

The Giants are just 7-14 (.333) after a loss this season — 2nd lowest in MLB; League Avg: .470.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

The Padres are batting .386 on the first pitch of at-bats this season — 2nd best in MLB.

Padres hitters have struck out in just 20% of their PA’s since the 2025 season — 3rd best in MLB.

Padres hitters have drawn walks in 7% of their PA’s against LHP this season — tied for 4th lowest in MLB.

Giants Hitting Stats & Trends

Giants hitters have an OBP of just .286 (1,300 PA’s) this season — lowest in MLB.

Giants hitters have drawn walks in 5% of their PA’s against RHP this season — lowest in MLB.

Giants hitters have an OBP of just .280 (896 PA’s) against RHP this season — lowest in MLB.

Giants hitters have an OBP of just .284 (2,027 PA’s) against LHP since the 2025 season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 47% against Padres pitchers this season — 3rd highest in MLB.

Opponents have a miss rate of 27% against Padres pitchers this season — tied for 4th best in MLB.

Opponents have a groundball batting average of .302 against Padres pitchers with runners on base this season — 2nd highest in MLB.

The Padres have allowed 3.58 runs per game (358/100) at home since the 2025 season — 2nd best in MLB.

Giants Pitching Stats & Trends

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB.

Opponents have a groundball rate of 48% against Giants pitchers this season — 2nd highest in MLB.

Opponents have a groundball rate of 46% against Giants pitchers since the 2025 season — 3rd highest in MLB.

Giants pitchers have induced opposing hitters to ground into 32 double plays in 252 opportunities (13%) this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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