• The Padres are -110 favorites vs the Nationals
• Padres vs Nationals Over / Under today: 9 Runs
• Padres / Nationals TV Channel: PDTV | NATV | WTTG

The San Diego Padres (-110) visit Nationals Park to take on the Washington Nationals (-110) on May 29, 2026. First pitch is scheduled for 6:45 pm in Washington, DC.

This season, the Padres are 31-24 against the spread (ATS), while the Nationals are 37-19 ATS.

Padres vs Nationals Starting Pitchers Today:

• Padres starting pitcher: Lucas Giolito 2-0, 2.70 ERA
• Nationals starting pitcher: Paxton Schultz 0-2, 5.41 ERA

Padres vs. Nationals Odds, Run Line, Over/Under & Moneyline

Padres vs Nationals Prediction for Today’s Game

Based on recent trends the model predicts the Nationals will win Friday‘s MLB game with 53.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Nationals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Friday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Gavin Sheets has hit the Home Runs Over in 4 of his last 7 away games (+22.90 Units / 327% ROI)
• Manny Machado has hit the Singles Under in 21 of his last 25 games (+15.60 Units / 47% ROI)
• Manny Machado has hit the Hits Under in 16 of his last 25 games (+14.85 Units / 59% ROI)
• Freddy Fermin has hit the Hits Runs and RBIs Under in 17 of his last 20 games (+14.85 Units / 59% ROI)
• Freddy Fermin has hit the Total Bases Under in 18 of his last 25 games (+12.20 Units / 45% ROI)

And here are some favorite MLB player prop bets for Nationals players for Friday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Best Bets Today:

• Jacob Young has hit the Home Runs Over in 4 of his last 10 games (+43.00 Units / 430% ROI)
• Luis Garcia has hit the Hits Under in 14 of his last 20 games at home (+15.11 Units / 59% ROI)
• James Wood has hit the Total Bases Over in 18 of his last 25 games at home (+10.80 Units / 35% ROI)
• Luis Garcia has hit the Runs Under in 13 of his last 15 games at home (+9.55 Units / 37% ROI)
• James Wood has hit the Hits Runs and RBIs Over in 17 of his last 25 games at home (+8.30 Units / 28% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 24 of their last 35 games (+11.50 Units / 28% ROI)
• The San Diego Padres have hit the Game Total Under in 17 of their last 24 games (+9.25 Units / 35% ROI)
• The San Diego Padres have hit the Moneyline in 15 of their last 22 away games (+9.00 Units / 36% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 19 away games (+6.05 Units / 26% ROI)
• The San Diego Padres have covered the Run Line in 28 of their last 50 games (+5.00 Units / 7% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 34 of their last 50 games (+15.55 Units / 25% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 28 of their last 40 games (+14.35 Units / 30% ROI)
• The Washington Nationals have hit the Moneyline in 25 of their last 45 games (+12.55 Units / 28% ROI)
• The Washington Nationals have covered the Run Line in 31 of their last 45 games (+11.95 Units / 18% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 games (+11.45 Units / 22% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 29-24 against the Run Line (+1.85 Units / 2.49% ROI).

• 31-24 when betting on the Moneyline for +4.55 Units / 6.7% ROI
• 22-31 when betting on the total runs Over for -12 Units / -19.79% ROI
• 31-22 when betting on the total runs Under for +6.9 Units / 11.41% ROI

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 37-19 against the Run Line (+12.25 Units / 15.22% ROI).

• 29-28 when betting on the Moneyline for +10.8 Units / 18.69% ROI
• 35-19 when betting on the total runs Over for +14.3 Units / 22.75% ROI
• 19-35 when betting on the total runs Under for -19.3 Units / -30.83% ROI

Nationals vs Padres Home Run Prop Bets Today

Nationals vs Padres Total Hits Prop Bets Today

Nationals vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Nationals

The Padres are 4-23 (.148) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .051.

The Padres are 15-8 (.652) on the road this season — 2nd best in MLB; League Avg: .477.

The Padres are 18-1 (.947) when scoring 5 or more runs this season — 2nd best in MLB; League Avg: .796.

The Padres are 12-1 (.923) when they’ve had 10 or more hits this season — 4th best in MLB; League Avg: .758.

Nationals Keys to the Game vs. the Padres

The Nationals are just 10-16 (.385) at home this season — 2nd lowest in MLB; League Avg: .523.

The Nationals are just 0-24 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

The Nationals are just 22-6 (.786) when leading entering the 7th inning this season — 5th lowest in MLB; League Avg: .865.

The Nationals are 23-5 (.821) when allowing 4 or fewer runs this season — 5th best in MLB; League Avg: .718.

Padres Hitting Stats & Trends

The Padres are batting just .218 this season — lowest in MLB.

Padres hitters have an OBP of just .270 (1,197 PA’s) with bases empty this season — lowest in MLB.

Padres hitters have an OBP of just .277 (448 PA’s) against LHP this season — lowest in MLB.

Padres hitters have an OBP of just .273 (1,143 PA’s) against starting pitchers this season — lowest in MLB.

Nationals Hitting Stats & Trends

The Nationals are batting just .177 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Nationals are batting .268 against LHP this season — 3rd best in MLB.

Nationals hitters have an OBP of .353 (659 PA’s) against LHP this season — best in MLB.

The Nationals are hitting just .172 against pitchers who have thrown at least 80 pitches in the game this season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 46% against Padres pitchers this season — tied for 4th highest in MLB.

Opponents have a miss rate of 27% against Padres pitchers this season — 5th best in MLB.

The Padres pitchers have allowed an average Exit Velocity of just 88.1 MPH this season (1,287 balls in play) — 3rd best in MLB

Padres pitchers have allowed an exit velocity of 95 MPH or greater 484 times this season — 2nd fewest in MLB.

Nationals Pitching Stats & Trends

Nationals pitchers have a strikeout rate of just 39% with two-strikes this season — tied for 2nd lowest in MLB.

Nationals pitchers have a strikeout rate of just 20% this season — tied for 4th lowest in MLB.

Opponents have a miss rate of just 22% against Nationals pitchers this season — lowest in MLB.

Nationals pitchers have allowed an average Exit Velocity of 90.1 MPH (1,521 batted balls) this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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