• The Padres are -105 favorites vs the Pirates
• Padres vs Pirates Over / Under today: 7.5 Runs
• Padres / Pirates TV Channel: PDTV | SNPT

The San Diego Padres (-105) visit PNC Park to take on the Pittsburgh Pirates (-115) on April 8, 2026. First pitch is scheduled for 12:35 pm in Pittsburgh, PA.

This season, the Padres are 5-6 against the spread (ATS), while the Pirates are 7-4 ATS.

Padres vs Pirates Starting Pitchers Today:

• Padres starting pitcher: Michael King 0-1, 3.38 ERA
• Pirates starting pitcher: Mitch Keller 1-0, 1.50 ERA

Padres vs. Pirates Odds, Run Line, Over/Under & Moneyline

Padres vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Wednesday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Pirates and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Jackson Merrill has hit the Home Runs Over in 3 of his last 9 away games (+10.80 Units / 120% ROI)
• Manny Machado has hit the Walks Over in 7 of his last 10 games (+9.45 Units / 94% ROI)
• Manny Machado has hit the Hits Runs and RBIs Under in 17 of his last 25 away games (+9.25 Units / 34% ROI)
• Gavin Sheets has hit the Hits Under in 15 of his last 25 games (+8.90 Units / 35% ROI)
• Ramon Laureano has hit the Singles Under in 18 of his last 25 games (+8.55 Units / 25% ROI)

And here are some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Ryan O’Hearn has hit the Total Bases Over in 17 of his last 20 games (+15.15 Units / 58% ROI)
• Ryan O’Hearn has hit the Hits Over in 18 of his last 20 games (+14.70 Units / 43% ROI)
• Bryan Reynolds has hit the Runs Over in 15 of his last 20 games at home (+14.10 Units / 70% ROI)
• Ryan O’Hearn has hit the Home Runs Over in 3 of his last 10 games (+13.40 Units / 134% ROI)
• Bryan Reynolds has hit the Walks Over in 11 of his last 15 games at home (+13.30 Units / 89% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Game Total Under in 24 of their last 40 games (+7.50 Units / 17% ROI)
• The San Diego Padres have hit the Team Total Under in 11 of their last 14 games (+7.35 Units / 43% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 10 of their last 17 games (+4.95 Units / 26% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 21 games (+4.45 Units / 18% ROI)
• The San Diego Padres have hit the Moneyline in 13 of their last 22 games (+3.90 Units / 15% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 33 of their last 50 games at home (+15.70 Units / 24% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games at home (+12.00 Units / 20% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 50 games at home (+11.20 Units / 18% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 28 of their last 45 games at home (+11.05 Units / 20% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games at home (+9.90 Units / 18% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 5-5 against the Run Line (-2.65 Units / -15.36% ROI).

• 5-6 when betting on the Moneyline for -0.75 Units / -6.2% ROI
• 4-6 when betting on the total runs Over for -2.55 Units / -21.16% ROI
• 6-4 when betting on the total runs Under for +1.6 Units / 13.17% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 7-4 against the Run Line (+3 Units / 20.91% ROI).

• 7-4 when betting on the Moneyline for +3.2 Units / 25% ROI
• 6-5 when betting on the total runs Over for +0.55 Units / 4.62% ROI
• 5-6 when betting on the total runs Under for -1.75 Units / -14.23% ROI

Padres Keys to the Game vs. the Pirates

The Padres were 48-12 (.800) when they had 10 or more hits in the 2025 season — 5th best in MLB; League Avg: .743.

The Padres are 26-6 (.812) when they’ve hit 2 or more home runs since the 2025 season — 5th best in MLB; League Avg: .702.

The Padres are 135-12 (.918) when leading entering the 7th inning since the 2024 season — 3rd best in MLB; League Avg: .866.

The Padres were 11-55 (.167) when trailing entering the 7th inning in the 2025 season — tied for 4th best in MLB; League Avg: .124.

Pirates Keys to the Game vs. the Padres

The Pirates are just 14-89 (.136) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB; League Avg: .251.

The Pirates were just 7-43 (.140) when allowing 10 or more hits in the 2025 season — 2nd lowest in MLB; League Avg: .256.

The Pirates are just 6-52 (.103) when allowing 5 or more runs since the 2025 season — 2nd lowest in MLB; League Avg: .204.

The Pirates were just 6-50 (.107) when they allowed 5 or more runs in the 2025 season — 2nd lowest in MLB; League Avg: .202.

Padres Hitting Stats & Trends

Padres hitters struck out in just 18% of their PA’s against LHP in the 2025 season — best in MLB.

Padres hitters have 15 extra-base hits out of 27 total hits (56%) with two-strikes this season — best in MLB.

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — tied for 2nd best in MLB.

Padres hitters struck out in just 19% of their PA’s in the 2025 season — 3rd best in MLB.

Pirates Hitting Stats & Trends

Pirates hitters had an OPS of just .622 (3,034 PA’s) on the road in the 2025 season — 2nd lowest in MLB.

Pirates hitters slugged just .159 on pitches out of the zone in the 2025 season — lowest in MLB.

Pirates hitters have an OPS of just .628 (3,279 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

The Pirates are batting just .152 in lefty-lefty matchups since the 2025 season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 51% against Padres pitchers this season — highest in MLB.

Padres pitchers had a strikeout rate of 24% in the 2025 season — tied for 4th best in MLB.

Padres pitchers had an ERA of 3.65 (1433.0 IP) in the 2025 season — 3rd best in MLB.

Padres pitchers had an ERA of 3.16 (738.0 IP) at home in the 2025 season — 2nd best in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 21% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Pirates pitchers won only 14% of games in which they allowed their opponent to score in three different innings in the 2025 season — 2nd lowest in MLB.

Pirates pitchers walked 7% of batters when facing the leadoff batter in the inning in the 2025 season — 5th best in MLB.

Pirates pitchers have a strikeout rate of 49% with two-strikes this season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Padres vs Pirates and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.