Padres vs Tigers Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

(AP Photo/Jeff Chiu)
  • The Padres are -105 favorites vs the Tigers
  • Padres vs Tigers Over / Under today: 7.5 Runs
  • Padres / Tigers TV Channel: FDDT | PDTV

The San Diego Padres (-105) visit Comerica Park to take on the Detroit Tigers (-115) on Tuesday, April 22, 2025. First pitch is scheduled for 6:40pm EDT in Detroit, MI, MI.

This season, the Padres are 16-7 against the spread (ATS), while the Tigers are 15-8 ATS.

Padres vs Tigers Starting Pitchers Today:

  • Padres starting pitcher: Nick Pivetta 3-1, 1.57 ERA
  • Tigers starting pitcher: Jack Flaherty 1-1, 2.49 ERA

Padres vs. Tigers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Padres-1.5 +165O 7.5 -120-105
Tigers +1.5 -200U 7.5 +100-115

Padres vs Tigers Prediction for Today’s Game

Based on recent trends the model predicts the Tigers will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

  • Gavin Sheets has hit the Home Runs Over in 2 of his last 6 games (+12.00 Units / 200% ROI)
  • Fernando Tatis Jr. has hit the RBIs Over in 12 of his last 20 games (+11.55 Units / 58% ROI)
  • Fernando Tatis Jr. has hit the Hits Over in 14 of his last 20 games (+11.20 Units / 35% ROI)
  • Xander Bogaerts has hit the Total Bases Over in 18 of his last 25 away games (+10.50 Units / 28% ROI)
  • Fernando Tatis Jr. has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+9.80 Units / 32% ROI)

And here are some favorite MLB player prop bets for Tigers players for Tuesday‘s game, looking at profitable historical betting trends:

Best Tigers Player Prop Best Bets Today:

  • Spencer Torkelson has hit the Total Bases Over in 20 of his last 25 games at home (+15.65 Units / 44% ROI)
  • Spencer Torkelson has hit the Hits Over in 21 of his last 25 games at home (+14.60 Units / 34% ROI)
  • Spencer Torkelson has hit the Home Runs Over in 4 of his last 10 games (+12.70 Units / 127% ROI)
  • Trey Sweeney has hit the Singles Under in 19 of his last 25 games at home (+9.25 Units / 22% ROI)
  • Gleyber Torres has hit the Runs Over in 14 of his last 20 games at home (+9.10 Units / 43% ROI)
  • The San Diego Padres have hit the Moneyline in 16 of their last 23 games (+9.10 Units / 30% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 19 games (+6.50 Units / 29% ROI)
  • The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 14 of their last 21 games (+6.10 Units / 25% ROI)
  • The San Diego Padres have hit the Team Total Over in 14 of their last 23 games (+4.40 Units / 17% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 12 of their last 20 games (+4.40 Units / 16% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 23 games (+9.65 Units / 37% ROI)
  • The Detroit Tigers have covered the Run Line in 9 of their last 11 games at home (+8.80 Units / 72% ROI)
  • The Detroit Tigers have hit the Moneyline in 14 of their last 20 games (+7.75 Units / 28% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Moneyline in 8 of their last 11 games at home (+6.90 Units / 38% ROI)
  • The Detroit Tigers have covered the 1st Five Innings (F5) Run Line in 9 of their last 11 games at home (+6.55 Units / 46% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 14-9 against the Run Line (+4.35 Units / 14.57% ROI).

  • 16-7 when betting on the Moneyline for +9.1 Units / 29.98% ROI
  • 10-12 when betting on the total runs Over for -3 Units / -12% ROI
  • 12-10 when betting on the total runs Under for +0.7 Units / 2.73% ROI

Tigers Against the Spread (ATS) Record

Against the spread this season, the Tigers are 15-8 against the Run Line (+6.85 Units / 22.76% ROI).

  • 14-9 when betting on the Moneyline for +4.75 Units / 15.4% ROI
  • 10-11 when betting on the total runs Over for -2.1 Units / -8.22% ROI
  • 11-10 when betting on the total runs Under for +0.3 Units / 1.2% ROI

Tigers vs Padres Home Run Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +333 0.5 -450
Manny Machado (SD) 0.5 +475 0.5 -650
Spencer Torkelson (DET) 0.5 +500 0.5 -750
Dillon Dingler (DET) 0.5 +675 0.5 -1100
Riley Greene (DET) 0.5 +700 0.5 -1200

Tigers vs Padres Total Hits Prop Bets Today

Over Under
Gleyber Torres (DET) 0.5 -275 0.5 +200
Manny Machado (SD) 0.5 -275 0.5 +195
Jose Iglesias (SD) 0.5 -250 0.5 +180
Xander Bogaerts (SD) 0.5 -200 0.5 +155
Oscar Gonzalez (SD) 0.5 -200 0.5 +150

Tigers vs Padres RBI Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +140 0.5 -185
Manny Machado (SD) 0.5 +165 0.5 -220
Spencer Torkelson (DET) 0.5 +175 0.5 -225
Riley Greene (DET) 0.5 +200 0.5 -275
Xander Bogaerts (SD) 0.5 +210 0.5 -275

Tigers vs Padres Strikeout Prop Bets Today

Over Under
Jack Flaherty (DET) 5.5 -110 5.5 -118
Nick Pivetta (SD) 6.5 +105 6.5 -140

Nick Pivetta has allowed an OPS of just .278 (45 PA’s) vs left-handed batters this season — 2nd best among qualified SPs in MLB; League Avg: .693 — 98th Percentile.

Left-handed batters are hitting just .098 (4-for-41) against Nick Pivetta this season — 2nd best among qualified SPs in MLB; League Avg: .232 — 98th Percentile.

Opponents are hitting just .056 (1-for-18) against Nick Pivetta’s elevated fastball this season — 3rd best among qualified SPs in MLB; League Avg: .215 — 96th Percentile.

Nick Pivetta has allowed an OBP of just .111 (45 PA’s) with two-strikes this season — best among qualified SPs in MLB; League Avg: .235 — 100th Percentile.

Tigers Starting Pitcher Stats & Trends

Jack Flaherty has thrown low pitches 61% of the time (155/255) in non-two strike counts this season — highest among among AL Starters; League Avg: 39% — 100th Percentile.

Jack Flaherty has a strikeout rate of 39% (14 SO in 36 PAs) when going through the lineup the first time in a game this season — tied for 5th best among qualified SPs in MLB; League Avg: 25% — 95th Percentile.

Jack Flaherty walked 9 of 252 batters (4%) when going through the lineup the first time in a game in the 2024 season — tied for 3rd best among qualified SPs in MLB; League Avg: 7% — 96th Percentile.

Opponents had a miss rate of 32% (393/1,223) against Jack Flaherty in the 2024 season — 2nd best among qualified SPs in MLB; League Avg: 26% — 98th Percentile.

Padres Keys to the Game vs. the Tigers

The Padres are 2-5 (.286) when trailing entering the 7th inning this season — tied for 2nd best in MLB; League Avg: .116.

The Padres are 76-8 (.905) when scoring 5 or more runs since last season — best in MLB; League Avg: .808.

The Padres are 12-1 (.923) at home this season — best in MLB; League Avg: .611.

The Padres are 52-39 (.571) on the road since last season — 2nd best in MLB; League Avg: .467.

Tigers Keys to the Game vs. the Padres

The Tigers are 1-8 (.111) when trailing entering the 9th inning this season — tied for 3rd best in MLB; League Avg: .033.

The Tigers were 18-54 (.250) when trailing entering the 7th inning in the 2024 season — best in MLB; League Avg: .143.

The Tigers are 7-67 (.095) when trailing entering the 9th inning since last season — 2nd best in MLB; League Avg: .048.

The Tigers were 13-55 (.191) when trailing entering the 8th inning in the 2024 season — best in MLB; League Avg: .100.

The Padres are batting .274 on the road since last season — best in MLB; League Avg: .240.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

Padres hitters have struck out in just 17% of it’s PA’s against LHP since last season — best in MLB; League Avg: 23%.

Padres hitters have struck out in just 17% of it’s PA’s this season — best in MLB; League Avg: 23%.

Tigers hitters had an OBP of just .300 (741 PA’s) when facing the starting pitcher for the 3rd time in a game in 2023 — lowest in MLB; League Avg: .330.

Tigers hitters slugged just .171 on pitches out of the zone in 2023 — 3rd lowest in MLB; League Avg: .211.

Tigers hitters had an OBP of just .263 (1,445 PA’s) when leading off an inning in the 2024 season — lowest in MLB; League Avg: .305.

Tigers hitters had an OPS of just .679 (4,707 PA’s) against RHP in the 2023 season — 3rd lowest in MLB; League Avg: .732.

The Padres pitchers have allowed their opponents to score first in just 26% of their games this season — tied for lowest in MLB; League Avg: 50%.

The Padres pitchers have allowed an average Exit Velocity of just 88.2 MPH since the 2023 season (8,425 balls in play) — best in MLB; League Avg: 88.9

The Padres have allowed 0.35 runs per game (8/23) in late innings this season — best in MLB; League Avg: 1.31.

Padres pitchers have an ERA of 1.30 (118.0 IP) at home this season — best in MLB; League Avg: 3.52.

Tigers pitchers have walked 7% of batters since last season — tied for 2nd best in MLB; League Avg: 8%.

Tigers pitchers walked 416 of 5,969 batters (7%) in the 2024 season — 2nd best in MLB; League Avg: 8%.

Tigers pitchers have an ERA of 3.11 (202.1 IP) this season — 3rd best in MLB; League Avg: 3.99.

Tigers pitchers have an ERA of 1.89 (100.0 IP) at home this season — 3rd best in MLB; League Avg: 3.52.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.