Phillies vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

Chicago Cubs' Nico Hoerner scores on a sacrifice by by Seiya Suzuki off Pittsburgh Pirates relief pitcher Dauri Moreta during the eighth inning of a baseball game in Pittsburgh, Tuesday, June 20, 2023. The Cubs won 4-0.
(AP Photo/Gene J. Puskar)
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  • The Phillies are +100 favorites vs the Cubs
  • Phillies vs Cubs Over / Under today: 8.5 Runs
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The Philadelphia Phillies (+100) visit Wrigley Field to take on the Chicago Cubs (-120) on April 21, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Phillies are 8-14 against the spread (ATS), while the Cubs are 10-12 ATS.

Phillies vs Cubs Starting Pitchers Today:

  • Phillies starting pitcher: Jesus Luzardo 1-3, 7.95 ERA
  • Cubs starting pitcher: Shota Imanaga 1-1, 2.46 ERA

Phillies vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Phillies-1.5 +165O 8.5 -115+100
Cubs +1.5 -200U 8.5 -105-120

Phillies vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Phillies players for Tuesday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Bets Today:

  • Alec Bohm has hit the Total Bases Under in 21 of his last 25 games (+16.90 Units / 45% ROI)
  • Adolis Garcia has hit the Runs Under in 17 of his last 20 games (+13.30 Units / 43% ROI)
  • Bryce Harper has hit the Walks Over in 11 of his last 15 away games (+11.85 Units / 79% ROI)
  • Alec Bohm has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+10.25 Units / 34% ROI)
  • Alec Bohm has hit the Hits Under in 8 of his last 10 games (+9.85 Units / 87% ROI)

And here are some favorite MLB player prop bets for Cubs players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • Dansby Swanson has hit the Home Runs Over in 4 of his last 8 games (+20.30 Units / 254% ROI)
  • Alex Bregman has hit the Runs Under in 21 of his last 25 games (+16.10 Units / 41% ROI)
  • Michael Busch has hit the Hits Under in 14 of his last 20 games (+12.40 Units / 52% ROI)
  • Michael Busch has hit the Total Bases Under in 15 of his last 20 games (+10.00 Units / 37% ROI)
  • Dansby Swanson has hit the Singles Under in 19 of his last 25 games (+9.30 Units / 23% ROI)
  • The Philadelphia Phillies have hit the Team Total Under in 23 of their last 30 games (+15.10 Units / 42% ROI)
  • The Philadelphia Phillies have hit the 1st Five Innings (F5) Team Total Under in 31 of their last 50 away games (+8.85 Units / 14% ROI)
  • The Philadelphia Phillies have hit the Game Total Under in 10 of their last 15 games (+4.65 Units / 28% ROI)
  • The Chicago Cubs have hit the Team Total Over in 17 of their last 25 games (+8.55 Units / 29% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 24 of their last 40 games at home (+6.85 Units / 14% ROI)
  • The Chicago Cubs have covered the Run Line in 13 of their last 21 games at home (+6.50 Units / 26% ROI)
  • The Chicago Cubs have hit the Moneyline in their last 6 games (+6.40 Units / 90% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games at home (+6.25 Units / 9% ROI)

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 4-18 against the Run Line (-14.9 Units / -61.7% ROI).

  • 8-14 when betting on the Moneyline for -11.45 Units / -33.48% ROI
  • 10-11 when betting on the total runs Over for -1.95 Units / -8.02% ROI
  • 11-10 when betting on the total runs Under for +0.25 Units / 1.04% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 10-12 against the Run Line (-1.8 Units / -6.91% ROI).

  • 13-9 when betting on the Moneyline for +0.05 Units / 0.16% ROI
  • 12-9 when betting on the total runs Over for +2.35 Units / 9.71% ROI
  • 9-12 when betting on the total runs Under for -4.2 Units / -17.28% ROI

Cubs vs Phillies Home Run Prop Bets Today

Yes
Kyle Schwarber +270
Adolis Garcia +390
Bryce Harper +390
Felix Reyes +400
Seiya Suzuki +425

Cubs vs Phillies Total Hits Prop Bets Today

Over Under
Alex Bregman 0.5 -220 0.5 +165
Seiya Suzuki 0.5 -210 0.5 +155
Alec Bohm 0.5 -210 0.5 +155
Bryce Harper 0.5 -200 0.5 +150
J.T. Realmuto 0.5 -190 0.5 +140

Cubs vs Phillies Strikeout Prop Bets Today

Over Under
Felix Reyes 0.5 -225 0.5 +165
Edmundo Sosa 0.5 -220 0.5 +165
Trea Turner 0.5 -210 0.5 +155
Miguel Amaya 0.5 -175 0.5 +130
Matthew Shaw 0.5 -165 0.5 +125

Phillies Keys to the Game vs. the Cubs

The Phillies were 15-45 (.250) when trailing entering the 7th inning in the 2025 season — best in MLB; League Avg: .124.

The Phillies are 17-58 (.227) when trailing entering the 7th inning since the 2025 season — best in MLB; League Avg: .125.

The Phillies were 69-5 (.932) when leading entering the 7th inning in the 2025 season — best in MLB; League Avg: .875.

The Phillies were 81-21 (.794) when they allowed 4 or fewer runs in the 2025 season — 2nd best in MLB; League Avg: .714.

Cubs Keys to the Game vs. the Phillies

The Cubs were 48-6 (.889) when they had 10 or more hits in the 2025 season — best in MLB; League Avg: .743.

The Cubs were 40-9 (.816) when they scored in the first inning in the 2025 season — best in MLB; League Avg: .636.

The Cubs are 43-9 (.827) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .636.

The Cubs are 75-19 (.798) when they’ve scored in the first inning since the 2024 season — best in MLB; League Avg: .638.

Phillies hitters chased 21% of pitches out of the zone on the first pitch of at-bats in the 2025 season — tied for highest in MLB.

The Phillies are batting just .176 against LHP this season — lowest in MLB.

Phillies hitters had an OPS of .764 (4,220 PA’s) against RHP in the 2025 season — 5th best in MLB.

Phillies hitters are slugging just .275 against LHP this season — lowest in MLB.

Cubs hitters struck out in just 20% of their PA’s against RHP in the 2025 season — 5th best in MLB.

Cubs hitters have 208 extra-base hits out of 566 total hits (37%) with two-strikes since the 2025 season — 2nd best in MLB.

Cubs hitters have an OPS of .788 (279 PA’s) against LHP this season — 3rd best in MLB.

Cubs hitters had an OPS of .761 (3,167 PA’s) on the road in the 2025 season — 3rd best in MLB.

Phillies pitchers walked 7% of batters in the 2025 season — 2nd best in MLB.

Phillies pitchers had a strikeout rate of 46% with two-strikes in the 2025 season — 2nd best in MLB.

Phillies pitchers have walked 7% of batters since the 2025 season — 2nd best in MLB.

Phillies pitchers had a strikeout rate of 24% in the 2025 season — 3rd best in MLB.

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers walked 7% of batters in the 2025 season — best in MLB.

Opponents had a miss rate of just 23% against Cubs pitchers in the 2025 season — 4th lowest in MLB.

Cubs pitchers had a strike rate of 66% in the 2025 season — highest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.