Phillies vs Padres Prediction, Odds & Player Prop Bets Today – MLB, May 25

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  • The Phillies are -130 favorites vs the Padres
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The Philadelphia Phillies (-130) visit Petco Park to take on the San Diego Padres (+105) on May 25, 2026. First pitch is scheduled for 6:40 pm in San Diego, CA.

This season, the Phillies are 26-27 against the spread (ATS), while the Padres are 29-22 ATS.

Phillies vs Padres Starting Pitchers Today:

  • Phillies starting pitcher: Jesus Luzardo 3-4, 4.85 ERA
  • Padres starting pitcher: Randy Vasquez 5-2, 2.97 ERA

Phillies vs. Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Phillies-1.5 +135O 7.5 -115-130
Padres +1.5 -165U 7.5 -105+105

Phillies vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Phillies will win Monday‘s MLB game with 56.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Phillies players for Monday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Bets Today:

  • Bryson Stott has hit the Home Runs Over in 3 of his last 9 away games (+20.50 Units / 228% ROI)
  • Brandon Marsh has hit the Hits Over in 17 of his last 20 away games (+13.05 Units / 34% ROI)
  • Kyle Schwarber has hit the Singles Under in 21 of his last 25 away games (+12.35 Units / 24% ROI)
  • Adolis Garcia has hit the Runs Under in 17 of his last 20 away games (+11.80 Units / 34% ROI)
  • J.T. Realmuto has hit the Total Bases Under in 8 of his last 9 away games (+7.45 Units / 49% ROI)

And here are some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

  • Freddy Fermin has hit the Hits Runs and RBIs Under in 17 of his last 20 games (+14.35 Units / 55% ROI)
  • Freddy Fermin has hit the Hits Under in 14 of his last 20 games (+10.90 Units / 51% ROI)
  • Nick Castellanos has hit the Home Runs Over in 2 of his last 6 games (+9.80 Units / 163% ROI)
  • Freddy Fermin has hit the Total Bases Under in 14 of his last 20 games (+8.95 Units / 40% ROI)
  • Freddy Fermin has hit the Singles Under in 18 of his last 25 games (+8.85 Units / 26% ROI)
  • team high – away
  • team high – home

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 16-37 against the Run Line (-22.75 Units / -37.33% ROI).

  • 26-27 when betting on the Moneyline for -8.45 Units / -11.09% ROI
  • 24-27 when betting on the total runs Over for -4.45 Units / -7.76% ROI
  • 27-24 when betting on the total runs Under for -0.1 Units / -0.18% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 29-22 against the Run Line (+6.05 Units / 8.85% ROI).

  • 31-21 when betting on the Moneyline for +9.35 Units / 14.82% ROI
  • 22-28 when betting on the total runs Over for -7.6 Units / -13.51% ROI
  • 28-22 when betting on the total runs Under for +2.9 Units / 5.17% ROI

Padres vs Phillies Home Run Prop Bets Today

Yes
Kyle Schwarber +230
Bryce Harper +390
Manny Machado +475
Adolis Garcia +575
Fernando Tatis Jr. +625

Padres vs Phillies Total Hits Prop Bets Today

Over Under
Trea Turner 0.5 -250 0.5 +180
Bryce Harper 0.5 -235 0.5 +175
Brandon Marsh 0.5 -235 0.5 +170
Miguel Andujar 0.5 -235 0.5 +175
Alec Bohm 0.5 -200 0.5 +145

Padres vs Phillies Strikeout Prop Bets Today

Over Under
Randy Vasquez 3.5 -118 3.5 -110
Jesus Luzardo 6.5 +100 6.5 -135

Phillies Keys to the Game vs. the Padres

The Phillies are just 1-12 (.077) when allowing 2 or more home runs this season — 2nd lowest in MLB; League Avg: .296.

The Phillies are 6-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .791.

The Phillies are 3-25 (.107) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .053.

The Phillies are 21-70 (.231) when trailing entering the 7th inning since the 2025 season — best in MLB; League Avg: .128.

Padres Keys to the Game vs. the Phillies

The Padres are 4-20 (.167) when trailing entering the 9th inning this season — best in MLB; League Avg: .053.

The Padres are 18-1 (.947) when scoring 5 or more runs this season — 2nd best in MLB; League Avg: .793.

The Padres are 4-19 (.174) when trailing entering the 8th inning this season — 5th best in MLB; League Avg: .105.

The Padres are 12-1 (.923) when they’ve had 10 or more hits this season — 4th best in MLB; League Avg: .754.

Phillies hitters have an OBP of just .215 (1,057 PA’s) with two-strikes this season — lowest in MLB.

Phillies hitters have an OPS of just .439 (1,057 PA’s) with two-strikes this season — 2nd lowest in MLB.

Phillies hitters have an OPS of just .631 (880 PA’s) on the road this season — 3rd lowest in MLB.

Phillies hitters have an OBP of just .298 (1,988 PA’s) this season — 4th lowest in MLB.

Padres hitters have an OPS of just .661 (1,894 PA’s) this season — 2nd lowest in MLB.

The Padres are batting just .207 against starting pitchers this season — lowest in MLB.

Padres hitters have an OBP of just .271 (1,129 PA’s) with bases empty this season — 2nd lowest in MLB.

Padres hitters have an OBP of just .280 (393 PA’s) against LHP this season — 2nd lowest in MLB.

Phillies pitchers have a strikeout rate of 47% with two-strikes this season — best in MLB.

Phillies pitchers have walked 7% of batters this season — 2nd best in MLB.

Opponents have a groundball batting average of .290 against Phillies pitchers this season — highest in MLB.

Phillies pitchers have allowed an average Exit Velocity of 87.7 MPH (1,322 batted balls) this season — best in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — 3rd highest in MLB.

Opponents have a miss rate of 28% against Padres pitchers this season — 5th best in MLB.

Opponents have a groundball batting average of .272 against Padres pitchers this season — 2nd highest in MLB.

Padres pitchers have a strikeout rate of 27% in late innings this season — 2nd best in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.