• The Phillies are -160 favorites vs the Padres
• Phillies vs Padres Over / Under today: 7 Runs
• Phillies / Padres TV Channel: NSPA | PDTV

The Philadelphia Phillies (-160) visit Petco Park to take on the San Diego Padres (+135) on May 27, 2026. First pitch is scheduled for 4:10 pm in San Diego, CA.

This season, the Phillies are 28-27 against the spread (ATS), while the Padres are 29-23 ATS.

Phillies vs Padres Starting Pitchers Today:

• Phillies starting pitcher: Cristopher Sanchez 5-2, 1.61 ERA
• Padres starting pitcher: Walker Buehler 3-2, 5.06 ERA

Phillies vs. Padres Odds, Run Line, Over/Under & Moneyline

Phillies vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Phillies will win Wednesday‘s MLB game with 59.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Phillies vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Phillies players for Wednesday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Bets Today:

• Brandon Marsh has hit the Hits Over in 22 of his last 25 games (+16.70 Units / 33% ROI)
• Bryce Harper has hit the Home Runs Over in 4 of his last 9 away games (+13.50 Units / 150% ROI)
• Bryce Harper has hit the Singles Under in 19 of his last 25 games (+11.60 Units / 38% ROI)
• Brandon Marsh has hit the Runs Over in 15 of his last 25 games (+11.30 Units / 45% ROI)
• Cristopher Sanchez has hit the Hits Allowed Over in 12 of his last 15 away games (+9.40 Units / 54% ROI)

And here are some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Manny Machado has hit the Singles Under in 21 of his last 25 games (+15.60 Units / 47% ROI)
• Manny Machado has hit the Home Runs Over in 4 of his last 10 games at home (+15.50 Units / 155% ROI)
• Manny Machado has hit the Hits Under in 16 of his last 25 games (+15.20 Units / 61% ROI)
• Freddy Fermin has hit the Hits Runs and RBIs Under in 17 of his last 20 games (+14.65 Units / 57% ROI)
• Jackson Merrill has hit the Runs Under in 14 of his last 15 games at home (+12.05 Units / 46% ROI)

Phillies Best Bets Today:

• The Philadelphia Phillies have hit the Game Total Under in 13 of their last 15 games (+10.80 Units / 65% ROI)
• The Philadelphia Phillies have hit the Moneyline in 11 of their last 14 away games (+8.40 Units / 52% ROI)
• The Philadelphia Phillies have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 games (+8.10 Units / 14% ROI)
• The Philadelphia Phillies have hit the Team Total Under in 30 of their last 50 away games (+8.05 Units / 14% ROI)
• The Philadelphia Phillies have hit the 1st Five Innings (F5) Moneyline in 10 of their last 15 away games (+7.35 Units / 40% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 24 of their last 35 games (+11.35 Units / 27% ROI)
• The San Diego Padres have hit the Game Total Under in 12 of their last 14 games at home (+9.80 Units / 65% ROI)
• The San Diego Padres have covered the Run Line in 23 of their last 40 games at home (+9.20 Units / 18% ROI)
• The San Diego Padres have hit the Moneyline in 30 of their last 50 games (+8.05 Units / 13% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games at home (+3.85 Units / 5% ROI)

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 17-37 against the Run Line (-23 Units / -35.55% ROI).

• 28-27 when betting on the Moneyline for -7.5 Units / -9.43% ROI
• 24-29 when betting on the total runs Over for -7.7 Units / -12.71% ROI
• 29-24 when betting on the total runs Under for +2.9 Units / 4.8% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 29-23 against the Run Line (+3.35 Units / 4.61% ROI).

• 31-23 when betting on the Moneyline for +5.55 Units / 8.3% ROI
• 22-30 when betting on the total runs Over for -10.95 Units / -18.37% ROI
• 30-22 when betting on the total runs Under for +5.9 Units / 9.94% ROI

Padres vs Phillies Home Run Prop Bets Today

Padres vs Phillies Total Hits Prop Bets Today

Padres vs Phillies Strikeout Prop Bets Today

Phillies Keys to the Game vs. the Padres

The Phillies are 15-4 (.789) when they’ve scored in the first inning this season — 4th best in MLB; League Avg: .640.

The Phillies are 5-25 (.167) when trailing entering the 8th inning this season — 5th best in MLB; League Avg: .102.

The Phillies are 6-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .788.

The Phillies are just 2-12 (.143) when allowing 2 or more home runs this season — tied for 2nd lowest in MLB; League Avg: .297.

Padres Keys to the Game vs. the Phillies

The Padres are 4-22 (.154) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .053.

The Padres are 12-1 (.923) when they’ve had 10 or more hits this season — 4th best in MLB; League Avg: .757.

The Padres are 5-2 (.714) when tied entering the 7th inning this season — 4th best in MLB; League Avg: .500.

The Padres are 18-1 (.947) when scoring 5 or more runs this season — 2nd best in MLB; League Avg: .792.

Phillies Hitting Stats & Trends

Phillies hitters have an OBP of just .282 (950 PA’s) on the road this season — lowest in MLB.

Phillies hitters have an OBP of just .217 (1,087 PA’s) with two-strikes this season — lowest in MLB.

The Phillies are batting just .149 with two-strikes this season — 3rd lowest in MLB.

Phillies hitters have an OPS of just .638 (950 PA’s) on the road this season — 3rd lowest in MLB.

Padres Hitting Stats & Trends

The Padres are batting just .218 this season — lowest in MLB.

The Padres are batting just .210 at home this season — 2nd lowest in MLB.

Padres hitters have an OPS of just .655 (1,963 PA’s) this season — 2nd lowest in MLB.

The Padres are batting just .206 against starting pitchers this season — lowest in MLB.

Phillies Pitching Stats & Trends

Phillies pitchers have a strikeout rate of 47% with two-strikes this season — best in MLB.

Phillies pitchers have a strikeout rate of 25% this season — tied for 3rd best in MLB.

Phillies pitchers have walked 7% of batters this season — 2nd best in MLB.

Opponents have a groundball batting average of .288 against Phillies pitchers this season — highest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 46% against Padres pitchers this season — 4th highest in MLB.

Opponents have a groundball batting average of .297 against Padres pitchers with runners on base this season — highest in MLB.

Opponents have a miss rate of 27% against Padres pitchers this season — 5th best in MLB.

The Padres pitchers have allowed an average Exit Velocity of just 88.0 MPH this season (1,229 balls in play) — 3rd best in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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