• The Brewers are -140 favorites vs the Pirates
• Pirates vs Brewers Over / Under today: 8 Runs
• Pirates / Brewers TV Channel: BRTV | SNP+

The Pittsburgh Pirates (+115) visit American Family Field to take on the Milwaukee Brewers (-140) on April 25, 2026. First pitch is scheduled for 7:10 pm in Milwaukee, WI.

This season, the Pirates are against the spread (ATS), while the Brewers are ATS.

Pirates vs Brewers Starting Pitchers Today:

• Pirates starting pitcher: Mitch Keller 2-1, 2.83 ERA
• Brewers starting pitcher: Jacob Misiorowski 1-2, 3.00 ERA

Pirates vs. Brewers Odds, Run Line, Over/Under & Moneyline

Pirates vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Saturday‘s MLB game with 52.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Brewers and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Saturday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Oneil Cruz has hit the Home Runs Over in 5 of his last 9 away games (+13.65 Units / 152% ROI)
• Ryan O’Hearn has hit the Hits Over in 20 of his last 25 games (+12.40 Units / 28% ROI)
• Ryan O’Hearn has hit the Singles Over in 15 of his last 20 away games (+11.80 Units / 57% ROI)
• Spencer Horwitz has hit the Walks Over in 9 of his last 15 games (+10.45 Units / 70% ROI)
• Ryan O’Hearn has hit the Total Bases Over in 17 of his last 25 games (+10.00 Units / 32% ROI)

And here are some favorite MLB player prop bets for Brewers players for Saturday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Best Bets Today:

• Jake Bauers has hit the Home Runs Over in 5 of his last 10 games at home (+20.00 Units / 200% ROI)
• Brice Turang has hit the Hits Runs and RBIs Over in 18 of his last 25 games at home (+10.35 Units / 35% ROI)
• Brandon Lockridge has hit the Runs Under in his last 10 games (+10.00 Units / 43% ROI)
• Brice Turang has hit the Walks Over in 8 of his last 10 games at home (+9.60 Units / 96% ROI)
• William Contreras has hit the Total Bases Over in 13 of his last 20 games (+9.10 Units / 42% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 24 of their last 35 games (+13.00 Units / 28% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games (+10.95 Units / 18% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 20 of their last 30 away games (+10.25 Units / 31% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 21 of their last 35 games (+7.10 Units / 17% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 35 games (+5.75 Units / 14% ROI)

Brewers Best Bets Today:

• The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 50 games at home (+10.90 Units / 19% ROI)
• The Milwaukee Brewers have covered the Run Line in 15 of their last 24 games at home (+8.40 Units / 30% ROI)
• The Milwaukee Brewers have hit the Team Total Over in 27 of their last 45 games at home (+6.60 Units / 12% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 23 of their last 40 games at home (+6.40 Units / 10% ROI)
• The Milwaukee Brewers have hit the Game Total Over in 28 of their last 50 games at home (+5.75 Units / 10% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Pirates Keys to the Game vs. the Brewers

The Pirates are just 1-9 (.100) when allowing 5 or more runs this season — 2nd lowest in MLB; League Avg: .232.

The Pirates are just 34-60 (.362) on the road since the 2025 season — 3rd lowest in MLB; League Avg: .458.

The Pirates are just 14-93 (.131) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB; League Avg: .252.

The Pirates are just 5-9 (.357) after a win this season — 5th lowest in MLB; League Avg: .524.

Brewers Keys to the Game vs. the Pirates

The Brewers are 82-9 (.901) when scoring 5 or more runs since the 2025 season — 2nd best in MLB; League Avg: .793.

The Brewers are just 8-4 (.667) when leading entering the 7th inning this season — tied for 3rd lowest in MLB; League Avg: .865.

The Brewers are 39-10 (.796) when they’ve hit 2 or more home runs since the 2025 season — 3rd best in MLB; League Avg: .698.

The Brewers are 31-25 (.554) vs the top 10 runs allowed teams since the 2025 season Today, they face Pirates (11th in runs allowed).

Pirates Hitting Stats & Trends

Pirates hitters have an OPS of just .626 (3,544 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters are slugging just .158 on pitches out of the zone since the 2025 season — lowest in MLB.

Pirates hitters have an OBP of just .290 (3,544 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters are slugging just .346 against LHP since the 2025 season — lowest in MLB.

Brewers Hitting Stats & Trends

Brewers hitters have a swing rate of just 45% against RHP since the 2025 season — lowest in MLB.

Brewers hitters have chased 19% of pitches out of the zone in non-two strike counts since the 2025 season — lowest in MLB.

Brewers hitters have a swing rate of just 45% since the 2025 season — lowest in MLB.

Brewers hitters have an OBP of .411 (284 PA’s) with runners in scoring position this season — best in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 14% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Pirates pitchers have a strikeout rate of 45% with two-strikes this season — 4th best in MLB.

Pirates pitchers have an ERA of 3.32 (238.1 IP) this season — 3rd best in MLB.

Pirates pitchers have allowed a slugging percentage of just .336 this season — best in MLB.

Brewers Pitching Stats & Trends

Brewers pitchers have picked-off 7 runners from first base this season — most in MLB.

Brewers pitchers have walked 9% of batters when facing the leadoff batter in the inning since the 2025 season — tied for 5th highest in MLB.

Brewers pitchers have walked 17% of batters when facing the leadoff batter in the inning over the past seven days (6 games) — 2nd highest in MLB.

Brewers pitchers have picked-off 8 runners this season — most in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Pirates vs Brewers and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.