• The Pirates are -102 favorites vs the Cardinals
• Pirates vs Cardinals Over / Under today: 8 Runs
• Pirates / Cardinals TV Channel: CATV | SNPT

The Pittsburgh Pirates (-102) visit Busch Stadium to take on the St. Louis Cardinals (-118) on May 19, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Pirates are 24-23 against the spread (ATS), while the Cardinals are 29-16 ATS.

Pirates vs Cardinals Starting Pitchers Today:

• Pirates starting pitcher: Mitch Keller 4-2, 3.61 ERA
• Cardinals starting pitcher: Matthew Liberatore 2-2, 4.41 ERA

Pirates vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Pirates vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Tuesday‘s MLB game with 53.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Pirates players for Tuesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Konnor Griffin has hit the Home Runs Over in 2 of his last 9 away games (+12.00 Units / 133% ROI)
• Spencer Horwitz has hit the Walks Over in 14 of his last 25 games (+12.00 Units / 48% ROI)
• Henry Davis has hit the Hits Under in 15 of his last 20 games (+10.55 Units / 50% ROI)
• Konnor Griffin has hit the Total Bases Over in 15 of his last 20 games (+10.35 Units / 36% ROI)
• Henry Davis has hit the Singles Under in 16 of his last 20 games (+8.80 Units / 24% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Pedro Pages has hit the Home Runs Over in 2 of his last 7 games at home (+13.00 Units / 186% ROI)
• Jordan Walker has hit the Runs Over in 16 of his last 25 games (+12.25 Units / 48% ROI)
• Nolan Gorman has hit the Hits Over in 18 of his last 25 games (+8.55 Units / 24% ROI)
• Ivan Herrera has hit the Total Bases Over in 15 of his last 25 games (+8.50 Units / 31% ROI)
• Alec Burleson has hit the RBIs Over in 9 of his last 15 games at home (+8.35 Units / 56% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 23 of their last 35 away games (+9.95 Units / 24% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 24 of their last 40 away games (+9.00 Units / 21% ROI)
• The Pittsburgh Pirates have covered the Run Line in 25 of their last 40 away games (+6.95 Units / 12% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 16 of their last 35 away games (+6.35 Units / 16% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 16 of their last 30 away games (+4.30 Units / 13% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 19 of their last 30 games (+11.60 Units / 38% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 16 of their last 30 games (+10.35 Units / 33% ROI)
• The St. Louis Cardinals have covered the Run Line in 22 of their last 30 games (+10.20 Units / 22% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 21 of their last 30 games (+10.05 Units / 27% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 16 of their last 25 games (+8.30 Units / 30% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 24-22 against the Run Line (+2.1 Units / 3.56% ROI).

• 24-23 when betting on the Moneyline for -4.05 Units / -6.61% ROI
• 25-21 when betting on the total runs Over for +1.6 Units / 3.06% ROI
• 21-25 when betting on the total runs Under for -6.25 Units / -12.22% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 29-16 against the Run Line (+5.9 Units / 8.57% ROI).

• 27-19 when betting on the Moneyline for +12.65 Units / 26.86% ROI
• 20-23 when betting on the total runs Over for -5.3 Units / -10.51% ROI
• 23-20 when betting on the total runs Under for +0.75 Units / 1.47% ROI

Cardinals vs Pirates Home Run Prop Bets Today

Cardinals vs Pirates Total Hits Prop Bets Today

Cardinals vs Pirates Strikeout Prop Bets Today

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 1-12 (.077) when allowing 10 or more hits this season — tied for 2nd lowest in MLB; League Avg: .246.

The Pirates are just 2-20 (.091) when allowing 5 or more runs this season — 2nd lowest in MLB; League Avg: .209.

The Pirates are just 0-17 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .050.

The Pirates are 22-3 (.880) when allowing 4 or fewer runs this season — 2nd best in MLB; League Avg: .723.

Cardinals Keys to the Game vs. the Pirates

The Cardinals are 3-16 (.158) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .050.

The Cardinals are 15-6 (.714) vs top 10 scoring offenses this season Today, they face the Pirates (seventh in runs scored).

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 148-10 (.937) when leading entering the 8th inning since the 2024 season — 4th best in MLB; League Avg: .903.

Pirates Hitting Stats & Trends

The Pirates are batting just .217 on the road this season — 3rd lowest in MLB.

The Pirates are batting .274 at home this season — best in MLB.

Pirates hitters have 28 extra-base hits out of 113 total hits (just 25%) against LHP this season — lowest in MLB.

Pirates hitters have an OBP of .343 (1,320 PA’s) against RHP this season — 4th best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have put 39% of their swings in play against LHP this season — tied for 4th highest in MLB.

Cardinals hitters have 29 extra-base hits out of 105 total hits (just 28%) against LHP this season — 4th lowest in MLB.

The Cardinals are batting just .211 with two outs this season — 5th lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Opponents have a groundball batting average of just .214 against Pirates pitchers this season — tied for 2nd best in MLB.

Pirates pitchers have allowed 39 home runs this season — tied for 3rd fewest in MLB.

Pirates pitchers have allowed three-ball counts to 19% of batters they faced (351/1,810 PA’s) this season — 4th lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 36% with two-strikes this season — lowest in MLB.

Cardinals pitchers have struck out just 17% of left-handed batters they faced this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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