• The Pirates are -102 favorites vs the Cardinals
• Pirates vs Cardinals Over / Under today: 8 Runs
• Pirates / Cardinals TV Channel: CATV | SNPT

The Pittsburgh Pirates (-102) visit Busch Stadium to take on the St. Louis Cardinals (-118) on May 20, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Pirates are 24-24 against the spread (ATS), while the Cardinals are 30-16 ATS.

Pirates vs Cardinals Starting Pitchers Today:

• Pirates starting pitcher: Carmen Mlodzinski 3-3, 4.44 ERA
• Cardinals starting pitcher: Michael McGreevy 3-2, 2.15 ERA

Pirates vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Pirates vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 51.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Spencer Horwitz has hit the Walks Over in 14 of his last 25 games (+12.00 Units / 48% ROI)
• Marcell Ozuna has hit the Hits Runs and RBIs Under in 16 of his last 20 away games (+11.50 Units / 44% ROI)
• Konnor Griffin has hit the Home Runs Over in 2 of his last 10 away games (+11.00 Units / 110% ROI)
• Konnor Griffin has hit the Total Bases Over in 15 of his last 20 games (+10.85 Units / 38% ROI)
• Konnor Griffin has hit the Runs Over in 12 of his last 20 games (+10.65 Units / 53% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• JJ Wetherholt has hit the Home Runs Over in 3 of his last 10 games at home (+13.70 Units / 137% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games at home (+11.10 Units / 44% ROI)
• Ivan Herrera has hit the Total Bases Over in 16 of his last 25 games (+11.00 Units / 40% ROI)
• Nolan Gorman has hit the Walks Over in 8 of his last 10 games (+9.70 Units / 97% ROI)
• Michael McGreevy has hit the Pitching Outs Over in 15 of his last 20 games (+9.60 Units / 41% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 23 of their last 35 away games (+9.95 Units / 24% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 24 of their last 40 away games (+8.90 Units / 21% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 18 of their last 40 away games (+6.10 Units / 13% ROI)
• The Pittsburgh Pirates have covered the Run Line in 27 of their last 45 away games (+5.85 Units / 9% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 16 of their last 30 away games (+4.30 Units / 13% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 24 of their last 40 games (+11.80 Units / 29% ROI)
• The St. Louis Cardinals have covered the Run Line in 22 of their last 30 games (+10.20 Units / 22% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 16 of their last 30 games (+9.15 Units / 29% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 20 of their last 30 games (+8.05 Units / 22% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 10 of their last 15 games (+6.70 Units / 40% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 24-23 against the Run Line (+1.1 Units / 1.83% ROI).

• 24-24 when betting on the Moneyline for -5.15 Units / -8.25% ROI
• 26-21 when betting on the total runs Over for +2.6 Units / 4.87% ROI
• 21-26 when betting on the total runs Under for -7.35 Units / -14.07% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 30-16 against the Run Line (+6.9 Units / 9.81% ROI).

• 28-19 when betting on the Moneyline for +13.65 Units / 28.32% ROI
• 21-23 when betting on the total runs Over for -4.3 Units / -8.34% ROI
• 23-21 when betting on the total runs Under for -0.35 Units / -0.67% ROI

Cardinals vs Pirates Home Run Prop Bets Today

Cardinals vs Pirates Total Hits Prop Bets Today

Cardinals vs Pirates Strikeout Prop Bets Today

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 0-18 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .052.

The Pirates are just 1-12 (.077) when allowing 10 or more hits this season — 3rd lowest in MLB; League Avg: .248.

The Pirates are 22-3 (.880) when allowing 4 or fewer runs this season — 2nd best in MLB; League Avg: .722.

The Pirates are 15-8 (.652) after a loss this season — 4th best in MLB; League Avg: .482.

Cardinals Keys to the Game vs. the Pirates

The Cardinals are 16-6 (.727) vs top 10 scoring offenses this season Today, they face the Pirates (seventh in runs scored).

The Cardinals are 3-16 (.158) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .052.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Pirates Hitting Stats & Trends

Pirates hitters have 29 extra-base hits out of 121 total hits (just 24%) against LHP this season — lowest in MLB.

Pirates hitters have struck out in 28% of their PA’s against LHP this season — 2nd highest in MLB.

Pirates hitters have an OPS of just .648 (876 PA’s) on the road this season — 3rd lowest in MLB.

Pirates hitters have come to the plate with runners in scoring position in 572 of their 1,895 plate appearances (30%) this season — 2nd highest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters are slugging .275 with two-strikes this season — 5th best in MLB.

Cardinals hitters are slugging .249 on pitches out of the zone this season — tied for 4th best in MLB.

The Cardinals are batting just .212 with two outs this season — 5th lowest in MLB.

Pirates Pitching Stats & Trends

Opponents have a groundball batting average of just .213 against Pirates pitchers this season — best in MLB.

Pirates pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Pirates pitchers have allowed three-ball counts to 19% of batters they faced (358/1,848 PA’s) this season — tied for 3rd lowest in MLB.

In games when their opponents have scored three or more runs in an inning, the Pirates won just 11% of the time since the 2025 season — lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 37% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — tied for 2nd lowest in MLB.

Cardinals pitchers have struck out just 17% of left-handed batters they faced this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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