• The Pirates are -150 favorites vs the Diamondbacks
• Pirates vs Diamondbacks Over / Under today: 8 Runs
• Pirates / Diamondbacks TV Channel: DBTV | SNPT

The Pittsburgh Pirates (-150) visit Chase Field to take on the Arizona Diamondbacks (+125) on May 6, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the Pirates are 19-17 against the spread (ATS), while the Diamondbacks are 22-12 ATS.

Pirates vs Diamondbacks Starting Pitchers Today:

• Pirates starting pitcher: Paul Skenes 4-2, 3.18 ERA
• Diamondbacks starting pitcher: Mike Soroka 4-1, 4.70 ERA

Pirates vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

Pirates vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Wednesday‘s MLB game with 61.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Diamondbacks and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Bryan Reynolds has hit the Walks Over in 15 of his last 20 games (+14.25 Units / 71% ROI)
• Ryan O’Hearn has hit the Singles Over in 15 of his last 20 away games (+11.55 Units / 55% ROI)
• Marcell Ozuna has hit the Total Bases Under in 12 of his last 15 away games (+10.10 Units / 55% ROI)
• Marcell Ozuna has hit the Hits Under in 11 of his last 15 away games (+10.05 Units / 67% ROI)
• Oneil Cruz has hit the RBIs Over in 11 of his last 20 games (+9.30 Units / 47% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Ildemaro Vargas has hit the Home Runs Over in 3 of his last 6 games at home (+21.60 Units / 360% ROI)
• Ildemaro Vargas has hit the Hits Over in 21 of his last 25 games (+16.30 Units / 36% ROI)
• Alek Thomas has hit the Singles Under in 20 of his last 25 games (+13.10 Units / 34% ROI)
• Ildemaro Vargas has hit the Total Bases Over in 17 of his last 25 games (+12.45 Units / 40% ROI)
• Ketel Marte has hit the Walks Under in 20 of his last 25 games (+11.90 Units / 31% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 27 of their last 45 games (+9.15 Units / 15% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 21 of their last 35 away games (+8.05 Units / 21% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 19 of their last 30 away games (+6.70 Units / 19% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 12 of their last 22 away games (+4.70 Units / 20% ROI)
• The Pittsburgh Pirates have hit the Team Total Over in 14 of their last 23 games (+3.55 Units / 13% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 32 of their last 50 games (+13.40 Units / 24% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 22 of their last 30 games at home (+12.60 Units / 34% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games at home (+11.55 Units / 19% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 26 of their last 40 games at home (+10.50 Units / 21% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 26 of their last 45 games (+8.75 Units / 18% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 19-16 against the Run Line (+2.15 Units / 4.6% ROI).

• 19-17 when betting on the Moneyline for -1.5 Units / -3.28% ROI
• 20-15 when betting on the total runs Over for +3.35 Units / 8.42% ROI
• 15-20 when betting on the total runs Under for -6.95 Units / -17.64% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 22-12 against the Run Line (+5.95 Units / 12.02% ROI).

• 17-17 when betting on the Moneyline for +1.25 Units / 3.32% ROI
• 20-12 when betting on the total runs Over for +7.15 Units / 19.14% ROI
• 12-20 when betting on the total runs Under for -9.8 Units / -26.1% ROI

Diamondbacks vs Pirates Home Run Prop Bets Today

Diamondbacks vs Pirates Total Hits Prop Bets Today

Diamondbacks vs Pirates Strikeout Prop Bets Today

Pirates Keys to the Game vs. the Diamondbacks

The Pirates are 11-5 (.688) after a loss this season — tied for 2nd best in MLB; League Avg: .470.

The Pirates are just 8-64 (.111) when allowing 5 or more runs since the 2025 season — lowest in MLB; League Avg: .205.

The Pirates are just 1-8 (.111) when allowing 10 or more hits this season — 4th lowest in MLB; League Avg: .243.

The Pirates are just 2-14 (.125) when allowing 5 or more runs this season — tied for 3rd lowest in MLB; League Avg: .216.

Diamondbacks Keys to the Game vs. the Pirates

The Diamondbacks are just 72-21 (.774) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .872.

The Diamondbacks are just 0-14 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .056.

The Diamondbacks are 4-10 (.286) when trailing entering the 7th inning this season — tied for 3rd best in MLB; League Avg: .144.

The Diamondbacks are just 80-15 (.842) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .906.

Pirates Hitting Stats & Trends

The Pirates are batting just .214 on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters have an OPS of just .619 (3,651 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters have an OPS of just .604 (2,260 PA’s) in innings 7-9 since the 2025 season — lowest in MLB.

Pirates hitters have 22 extra-base hits out of 90 total hits (just 24%) against LHP this season — lowest in MLB.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have a swing rate of just 24% on the first pitch of at-bats this season — lowest in MLB.

The Diamondbacks are batting .282 against LHP this season — best in MLB.

Diamondbacks hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 3rd best in MLB.

Diamondbacks hitters have chased 47% of pitches out of the zone with two-strikes this season — highest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Pirates pitchers have allowed 28 home runs this season — tied for fewest in MLB.

Pirates pitchers have allowed a slugging percentage of just .354 this season — 5th best in MLB.

Pirates pitchers have a strikeout rate of 26% over the last 14 days — 3rd best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — tied for 4th best in MLB.

Diamondbacks pitchers have an ERA of 7.28 (94.0 IP) over the last 14 days — highest in MLB.

Diamondbacks pitchers have a strikeout rate of just 19% this season — 3rd lowest in MLB.

Opponents have a miss rate of just 24% against Diamondbacks pitchers since the 2025 season — tied for 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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