• The Pirates are -160 favorites vs the Reds
• Pirates vs Reds Over / Under today: 7.5 Runs
• Pirates / Reds TV Channel: RDTV | SNPT

The Pittsburgh Pirates (-160) visit Great American Ball Park to take on the Cincinnati Reds (+135) on April 1, 2026. First pitch is scheduled for 12:40 pm in Cincinnati, OH.

This season, the Pirates are against the spread (ATS), while the Reds are ATS.

Pirates vs Reds Starting Pitchers Today:

• Pirates starting pitcher: Paul Skenes 0-1, 67.57 ERA
• Reds starting pitcher: Andrew Abbott 0-0, 0.00 ERA

Pirates vs. Reds Odds, Run Line, Over/Under & Moneyline

Pirates vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Wednesday‘s MLB game with 60.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Reds and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Ryan O’Hearn has hit the Total Bases Over in 14 of his last 15 games (+13.35 Units / 64% ROI)
• Brandon Lowe has hit the Home Runs Over in 4 of his last 10 games (+12.80 Units / 128% ROI)
• Ryan O’Hearn has hit the Hits Over in 14 of his last 15 games (+12.60 Units / 52% ROI)
• Ryan O’Hearn has hit the Singles Over in 17 of his last 25 games (+12.00 Units / 47% ROI)
• Paul Skenes has hit the Earned Runs Under in 17 of his last 25 games (+8.15 Units / 28% ROI)

And here are some favorite MLB player prop bets for Reds players for Wednesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Elly De La Cruz has hit the Home Runs Over in 3 of his last 8 games (+12.40 Units / 155% ROI)
• Eugenio Suarez has hit the Hits Over in 13 of his last 15 games (+10.50 Units / 48% ROI)
• Will Benson has hit the Runs Under in 13 of his last 15 games at home (+10.25 Units / 41% ROI)
• Eugenio Suarez has hit the Total Bases Under in 17 of his last 25 games at home (+8.90 Units / 27% ROI)
• Andrew Abbott has hit the Earned Runs Under in 12 of his last 15 games at home (+8.55 Units / 44% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have hit the Game Total Under in 88 of their last 150 games (+27.90 Units / 17% ROI)
• The Pittsburgh Pirates have hit the Team Total Under in 92 of their last 151 games (+26.80 Units / 15% ROI)
• The Pittsburgh Pirates have covered the Run Line in 77 of their last 124 games (+24.60 Units / 15% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 41 of their last 64 away games (+15.55 Units / 20% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 60 of their last 104 games (+11.80 Units / 10% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Under in 84 of their last 141 games (+30.15 Units / 19% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 43 of their last 76 games (+6.15 Units / 7% ROI)
• The Cincinnati Reds have hit the Moneyline in 36 of their last 60 games at home (+6.00 Units / 8% ROI)
• The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 9 of their last 13 games (+4.10 Units / 26% ROI)
• The Cincinnati Reds have hit the Team Total Under in their last 4 games at home (+4.00 Units / 75% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Pirates Keys to the Game vs. the Reds

The Pirates were just 27-54 (.333) on the road in the 2025 season — tied for 2nd lowest in MLB; League Avg: .457.

The Pirates were just 13-24 (.351) vs bottom 10 scoring offenses in the 2025 season Today, they face the Reds (25th in runs scored).

The Pirates were just 6-50 (.107) when they allowed 5 or more runs in the 2025 season — 2nd lowest in MLB; League Avg: .202.

The Pirates were just 4-75 (.051) when trailing entering the 8th inning in the 2025 season — tied for 2nd lowest in MLB; League Avg: .090.

Reds Keys to the Game vs. the Pirates

The Reds were just 7-50 (.123) when they allowed 5 or more runs in the 2025 season — 3rd lowest in MLB; League Avg: .202.

The Reds are just 12-27 (.308) when tied entering the 8th inning since the 2024 season — 2nd lowest in MLB; League Avg: .500.

The Reds are just 8-126 (.060) when trailing entering the 8th inning since the 2024 season — tied for 2nd lowest in MLB; League Avg: .095.

The Reds are just 11-122 (.083) when trailing entering the 7th inning since the 2024 season — 3rd lowest in MLB; League Avg: .133.

Pirates Hitting Stats & Trends

The Pirates won only 33% of their road games in the 2025 season — tied for 2nd lowest in MLB.

Pirates hitters had an OPS of just .622 (3,034 PA’s) on the road in the 2025 season — 2nd lowest in MLB.

Pirates hitters are slugging just .354 against RHP since the 2025 season — lowest in MLB.

Pirates hitters are slugging just .350 since the 2025 season — lowest in MLB.

Reds Hitting Stats & Trends

Reds hitters have a swing rate of just 39% in lefty-lefty matchups since the 2025 season — lowest in MLB.

Reds hitters have an OPS of just .314 (37 PA’s) in innings 7-9 this season — lowest in MLB.

Reds hitters are slugging just .348 against LHP since the 2025 season — 3rd lowest in MLB.

The Reds are batting just .226 against LHP since the 2024 season — lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 24% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Pirates pitchers have a strikeout rate of 49% in late innings this season — best in MLB.

Pirates pitchers won only 14% of games in which they allowed their opponent to score in three different innings in the 2025 season — 2nd lowest in MLB.

Pirates pitchers walked 7% of batters when facing the leadoff batter in the inning in the 2025 season — 5th best in MLB.

Reds Pitching Stats & Trends

Opponents had a groundball rate of just 40% against Reds pitchers in the 2025 season — tied for 3rd lowest in MLB.

Reds pitchers have a strikeout rate of 39% with runners in scoring position this season — 2nd best in MLB.

Reds pitchers have a strikeout rate of 55% when going through the lineup the third time in a game this season — best in MLB.

Reds pitchers induced opposing hitters to ground into just 84 double plays in 1,060 opportunities (8%) in the 2025 season — tied for 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Pirates vs Reds and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.