• The Yankees are -170 favorites vs the Pirates
• Pirates vs Yankees Over / Under today: 8.5 Runs
• Pirates / Yankees TV Channel: YES | SNPT

The Pittsburgh Pirates (+140) visit Yankee Stadium to take on the New York Yankees (-170) on July 22, 2026. First pitch is scheduled for 7:05 pm in Bronx, NY.

This season, the Pirates are 52-49 against the spread (ATS), while the Yankees are 48-51 ATS.

Pirates vs Yankees Starting Pitchers Today:

• Pirates starting pitcher: Mitch Keller 6-7, 5.14 ERA
• Yankees starting pitcher: Gerrit Cole 3-5, 3.96 ERA

Pirates vs. Yankees Odds, Run Line, Over/Under & Moneyline

Pirates vs Yankees Prediction for Today’s Game

Based on recent trends the model predicts the Yankees will win Wednesday‘s MLB game with 53.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Yankees and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Esmerlyn Valdez has hit the Home Runs Over in 6 of his last 8 games (+22.70 Units / 284% ROI)
• Esmerlyn Valdez has hit the RBIs Over in his last 8 games (+12.90 Units / 161% ROI)
• Esmerlyn Valdez has hit the Hits Runs and RBIs Over in 16 of his last 20 games (+12.15 Units / 54% ROI)
• Esmerlyn Valdez has hit the Runs Over in 14 of his last 20 games (+11.60 Units / 57% ROI)
• Esmerlyn Valdez has hit the Total Bases Over in 15 of his last 20 games (+11.40 Units / 47% ROI)

And here are some favorite MLB player prop bets for Yankees players for Wednesday‘s game, looking at profitable historical betting trends:

Best Yankees Player Prop Best Bets Today:

• Cody Bellinger has hit the RBIs Under in 22 of his last 25 games (+15.30 Units / 28% ROI)
• Cody Bellinger has hit the Runs Under in 21 of his last 25 games (+14.35 Units / 36% ROI)
• Cody Bellinger has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+12.35 Units / 41% ROI)
• Jazz Chisholm has hit the Walks Under in 20 of his last 25 games at home (+10.55 Units / 21% ROI)
• Paul Goldschmidt has hit the Hits Under in 7 of his last 9 games at home (+8.60 Units / 71% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have hit the Game Total Over in 30 of their last 45 games (+14.95 Units / 31% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 23 games (+12.80 Units / 46% ROI)
• The Pittsburgh Pirates have hit the Team Total Over in 17 of their last 22 games (+11.70 Units / 46% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 away games (+6.40 Units / 11% ROI)
• The Pittsburgh Pirates have covered the Run Line in 15 of their last 24 games (+4.70 Units / 15% ROI)

Yankees Best Bets Today:

• The New York Yankees have hit the Team Total Under in 20 of their last 25 games at home (+14.30 Units / 47% ROI)
• The New York Yankees have hit the 1st Five Innings (F5) Team Total Under in 18 of their last 25 games (+11.05 Units / 37% ROI)
• The New York Yankees have hit the Game Total Under in 16 of their last 25 games (+6.40 Units / 24% ROI)
• The New York Yankees have covered the Run Line in 7 of their last 8 games (+6.05 Units / 57% ROI)
• The New York Yankees have hit the Moneyline in 6 of their last 8 games (+4.35 Units / 45% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 51-48 against the Run Line (+1.65 Units / 1.32% ROI).

• 52-49 when betting on the Moneyline for -5.65 Units / -4.46% ROI
• 59-39 when betting on the total runs Over for +16.25 Units / 14.62% ROI
• 39-59 when betting on the total runs Under for -25.7 Units / -23.13% ROI

Yankees Against the Spread (ATS) Record

Against the spread this season, the Yankees are 48-51 against the Run Line (+0.8 Units / 0.71% ROI).

• 56-44 when betting on the Moneyline for -6.75 Units / -4.54% ROI
• 44-52 when betting on the total runs Over for -13.8 Units / -12.46% ROI
• 52-44 when betting on the total runs Under for +3.85 Units / 3.52% ROI

Pirates Keys to the Game vs. the Yankees

The Pirates are 40-9 (.816) when allowing 4 or fewer runs this season — 3rd best in MLB; League Avg: .727.

The Pirates are just 4-26 (.133) when allowing 10 or more hits this season — 3rd lowest in MLB; League Avg: .247.

The Pirates are just 23-29 (.442) after a win this season — 5th lowest in MLB; League Avg: .514.

The Pirates are 40-9 (.816) when allowing 4 or fewer runs since the 2025 season — 3rd best in MLB; League Avg: .727.

Yankees Keys to the Game vs. the Pirates

The Yankees are 36-4 (.900) when they’ve hit 2 or more home runs this season — best in MLB; League Avg: .697.

The Yankees are 25-2 (.926) when they’ve had 10 or more hits this season — best in MLB; League Avg: .753.

The Yankees are 4-38 (.095) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .053.

The Yankees are 18-1 (.947) when they’ve had 5 or more XBH this season — 3rd best in MLB; League Avg: .786.

Pirates Hitting Stats & Trends

Pirates hitters have an OBP of .351 (2,833 PA’s) against RHP this season — best in MLB.

The Pirates are batting .310 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Pirates hitters have an OPS of .786 (2,833 PA’s) against RHP this season — best in MLB.

The Pirates are batting .297 on fastballs this season — best in MLB.

Yankees Hitting Stats & Trends

Yankees hitters are slugging .475 with runners on base this season — best in MLB.

Yankees hitters have 186 extra-base hits out of 423 total hits (44%) against starting pitchers this season — best in MLB.

Yankees hitters have drawn walks in 13% of their PA’s when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Yankees hitters have 108 extra-base hits out of 270 total hits (40%) against LHP this season — best in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have a strikeout rate of 24% this season — tied for 5th best in MLB.

The Pirates pitchers have allowed their opponents to score first in just 40% of their games on the road this season — 5th lowest in MLB.

The Pirates have allowed 1.73 runs per game (175/101) in late innings this season — tied for 2nd highest in MLB.

The Pirates pitchers have allowed their opponents to score first in just 45% of their games at home this season — 3rd lowest in MLB.

Yankees Pitching Stats & Trends

Yankees pitchers have an ERA of 3.11 (462.2 IP) on the road this season — best in MLB.

Yankees pitchers have a strikeout rate of 45% with two-strikes this season — 5th best in MLB.

Opponents have a groundball rate of 45% against Yankees pitchers this season — 4th highest in MLB.

The Yankees have allowed 3.43 runs per game (182/53) on the road this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Pirates vs Yankees and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.