• The Red Sox are -145 favorites vs the Cardinals
• Red Sox vs Cardinals Over / Under today: 7.5 Runs
• Red Sox / Cardinals TV Channel: NESN | CATV

The Boston Red Sox (-145) visit Busch Stadium to take on the St. Louis Cardinals (+120) on April 10, 2026. First pitch is scheduled for 8:15 pm in St. Louis, MO.

This season, the Red Sox are 4-8 against the spread (ATS), while the Cardinals are 6-5 ATS.

Red Sox vs Cardinals Starting Pitchers Today:

• Red Sox starting pitcher: Connelly Early 0-0, 2.90 ERA
• Cardinals starting pitcher: Dustin May 0-2, 16.73 ERA

Red Sox vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Red Sox vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Friday‘s MLB game with 61.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Red Sox players for Friday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Bets Today:

• Caleb Durbin has hit the Hits Under in 15 of his last 25 games (+11.40 Units / 46% ROI)
• Caleb Durbin has hit the Hits Runs and RBIs Under in 19 of his last 25 away games (+10.10 Units / 28% ROI)
• Trevor Story has hit the Runs Under in his last 10 games (+10.00 Units / 62% ROI)
• Wilyer Abreu has hit the Home Runs Over in 3 of his last 5 away games (+9.90 Units / 198% ROI)
• Marcelo Mayer has hit the Singles Under in his last 9 games (+9.00 Units / 56% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Jordan Walker has hit the Home Runs Over in 5 of his last 9 games (+25.10 Units / 279% ROI)
• Ivan Herrera has hit the Walks Over in his last 8 games (+12.60 Units / 158% ROI)
• Ivan Herrera has hit the Runs Under in 13 of his last 15 games (+10.05 Units / 44% ROI)
• Thomas Saggese has hit the Total Bases Over in 17 of his last 25 games (+9.45 Units / 26% ROI)
• Thomas Saggese has hit the Hits Over in 19 of his last 25 games (+8.75 Units / 20% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the Game Total Under in 22 of their last 35 games (+8.80 Units / 23% ROI)
• The Boston Red Sox have hit the Team Total Under in 13 of their last 19 games (+6.55 Units / 28% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 35 away games (+5.40 Units / 13% ROI)
• The Boston Red Sox have hit the Moneyline in 21 of their last 40 away games (+1.10 Units / 2% ROI)
• The Boston Red Sox have covered the Run Line in 10 of their last 19 away games (+0.25 Units / 1% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 35 games at home (+7.65 Units / 19% ROI)
• The St. Louis Cardinals have hit the Moneyline in 11 of their last 17 games at home (+5.75 Units / 32% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 13 of their last 20 games at home (+5.15 Units / 23% ROI)
• The St. Louis Cardinals have hit the Team Total Over in their last 5 games (+5.10 Units / 86% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 7 of their last 9 games at home (+4.95 Units / 45% ROI)

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 3-9 against the Run Line (-6.05 Units / -45.32% ROI).

• 4-8 when betting on the Moneyline for -6.4 Units / -39.63% ROI
• 6-6 when betting on the total runs Over for -0.7 Units / -5.3% ROI
• 6-6 when betting on the total runs Under for -0.65 Units / -4.91% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 6-5 against the Run Line (-0.5 Units / -3.05% ROI).

• 7-5 when betting on the Moneyline for +2.95 Units / 23.69% ROI
• 6-5 when betting on the total runs Over for +0.5 Units / 3.85% ROI
• 5-6 when betting on the total runs Under for -1.9 Units / -14.13% ROI

Red Sox Keys to the Game vs. the Cardinals

The Red Sox were 71-4 (.947) when leading entering the 8th inning in the 2025 season — tied for 2nd best in MLB; League Avg: .909.

The Red Sox are just 4-8 (.333) this season — tied for 3rd lowest in MLB; League Avg: .500.

The Red Sox are just 4-7 (.364) when allowing 5 or more extra base hits this season — 3rd lowest in MLB; League Avg: .520.

The Red Sox are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .030.

Cardinals Keys to the Game vs. the Red Sox

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are just 8-12 (.400) when tied entering the 8th inning since the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 28-18 (.609) when tied entering the 7th inning since the 2024 season — tied for 4th best in MLB; League Avg: .499.

The Cardinals are 132-8 (.943) when leading entering the 8th inning since the 2024 season — 4th best in MLB; League Avg: .904.

Red Sox Hitting Stats & Trends

Red Sox hitters have struck out in just 16% of their PA’s against LHP this season — 3rd best in MLB.

Red Sox hitters have put 45% of their swings in play against LHP this season — tied for 2nd highest in MLB.

Red Sox hitters came to the plate with runners in scoring position in 1,740 of their 6,208 plate appearances (28%) in the 2025 season — highest in MLB.

Red Sox hitters had an OBP of .331 (3,034 PA’s) at home in the 2025 season — 5th best in MLB.

Cardinals Hitting Stats & Trends

The Cardinals are batting just .133 when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .332 against RHP this season — 4th lowest in MLB.

Cardinals hitters slugged just .380 against RHP in the 2025 season — tied for 3rd lowest in MLB.

Cardinals hitters slugged just .489 when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Red Sox Pitching Stats & Trends

Red Sox pitchers have walked 5% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

Opponents had a groundball rate of 46% against Red Sox pitchers in the 2025 season — 4th highest in MLB.

Opponents have a groundball batting average of just .181 against Red Sox pitchers this season — 2nd best in MLB.

Red Sox pitchers had an ERA of 3.84 (705.1 IP) on the road in the 2025 season — 3rd best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 33% with two-strikes this season — lowest in MLB.

Cardinals pitchers had a strikeout rate of just 20% in the 2025 season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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