• The Cubs are -210 favorites vs the Reds
• Reds vs Cubs Over / Under today: 11.5 Runs
• Reds / Cubs TV Channel: WXIX | MARQ | RDTV

The Cincinnati Reds (+170) visit Wrigley Field to take on the Chicago Cubs (-210) on May 4, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Reds are 20-14 against the spread (ATS), while the Cubs are 17-17 ATS.

Reds vs Cubs Starting Pitchers Today:

• Reds starting pitcher: Chase Petty 0-0, 0.00 ERA
• Cubs starting pitcher: Edward Cabrera 3-0, 3.12 ERA

Reds vs. Cubs Odds, Run Line, Over/Under & Moneyline

Reds vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Monday‘s MLB game with 62.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Monday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Nate Lowe has hit the Home Runs Over in 4 of his last 9 games (+17.30 Units / 192% ROI)
• Ke’Bryan Hayes has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+15.20 Units / 44% ROI)
• Will Benson has hit the Runs Under in 18 of his last 20 games (+14.35 Units / 36% ROI)
• TJ Friedl has hit the Walks Under in 14 of his last 15 games (+12.50 Units / 47% ROI)
• Ke’Bryan Hayes has hit the Total Bases Under in 17 of his last 25 games (+11.40 Units / 44% ROI)

And here are some favorite MLB player prop bets for Cubs players for Monday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Ian Happ has hit the Home Runs Over in 4 of his last 10 games at home (+13.90 Units / 139% ROI)
• Carson Kelly has hit the Singles Over in 15 of his last 20 games (+11.45 Units / 56% ROI)
• Ian Happ has hit the Hits Runs and RBIs Over in 15 of his last 20 games at home (+11.10 Units / 51% ROI)
• Seiya Suzuki has hit the Total Bases Over in 15 of his last 20 games at home (+10.75 Units / 42% ROI)
• Ian Happ has hit the Runs Over in 14 of his last 20 games at home (+10.65 Units / 48% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Over in 18 of their last 24 games (+11.35 Units / 43% ROI)
• The Cincinnati Reds have hit the Moneyline in 29 of their last 50 games (+7.40 Units / 13% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 28 of their last 50 away games (+3.65 Units / 6% ROI)
• The Cincinnati Reds have covered the Run Line in 11 of their last 18 games (+3.25 Units / 12% ROI)
• The Cincinnati Reds have hit the Team Total Over in 9 of their last 14 games (+2.90 Units / 17% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 30 of their last 45 games at home (+14.45 Units / 27% ROI)
• The Chicago Cubs have hit the Team Total Over in 19 of their last 25 games (+12.80 Units / 44% ROI)
• The Chicago Cubs have hit the Moneyline in 15 of their last 18 games (+12.75 Units / 58% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 31 of their last 50 games at home (+12.30 Units / 16% ROI)
• The Chicago Cubs have hit the Game Total Over in 18 of their last 25 games (+11.30 Units / 40% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 20-13 against the Run Line (+2.6 Units / 5.02% ROI).

• 20-14 when betting on the Moneyline for +6.3 Units / 16.43% ROI
• 21-12 when betting on the total runs Over for +7.8 Units / 20.83% ROI
• 12-21 when betting on the total runs Under for -11.05 Units / -29.59% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 17-17 against the Run Line (+0.6 Units / 1.48% ROI).

• 22-12 when betting on the Moneyline for +6.4 Units / 13.85% ROI
• 22-11 when betting on the total runs Over for +10.15 Units / 27.07% ROI
• 11-22 when betting on the total runs Under for -13.1 Units / -34.98% ROI

Cubs vs Reds Home Run Prop Bets Today

Cubs vs Reds Total Hits Prop Bets Today

Cubs vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Cubs

The Reds are 3-14 (.176) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .056.

The Reds are 15-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .889.

The Reds are 4-10 (.286) when trailing entering the 7th inning this season — tied for best in MLB; League Avg: .145.

The Reds are 8-2 (.800) when they’ve scored in the first inning this season — tied for 3rd best in MLB; League Avg: .633.

Cubs Keys to the Game vs. the Reds

The Cubs are 45-9 (.833) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .636.

The Cubs are 60-7 (.896) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .746.

The Cubs are 10-3 (.769) vs bottom 10 scoring offenses this season Today, they face the Reds (22nd in runs scored).

The Cubs are 18-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .855.

Reds Hitting Stats & Trends

The Reds are batting just .183 with two outs this season — 2nd lowest in MLB.

The Reds are batting just .196 with runners on base this season — lowest in MLB.

Reds hitters have an OPS of just .268 (34 PA’s) in lefty-lefty matchups this season — lowest in MLB.

The Reds are batting just .109 on pitches out of the zone this season — 2nd lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .401 (299 PA’s) when leading off an inning this season — best in MLB.

Cubs hitters have an OPS of .833 (438 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .374 (438 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .285 (688 PA’s) with two-strikes this season — best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a first-pitch strike rate of just 56% this season — lowest in MLB.

Reds pitchers have walked 12% of batters this season — tied for 2nd highest in MLB.

Reds pitchers have a strike rate of just 61% this season — lowest in MLB.

Reds pitchers have an ERA of 7.59 (51.0 IP) against division opponents this season — 2nd highest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Opponents have a miss rate of just 24% against Cubs pitchers since the 2025 season — 5th lowest in MLB.

Cubs pitchers walked 7% of batters in the 2025 season — best in MLB.

Cubs pitchers have an ERA of 5.13 (128.0 IP) on the road this season — 4th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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