• The Cubs are -185 favorites vs the Reds
• Reds vs Cubs Over / Under today: 8 Runs
• Reds / Cubs TV Channel: MARQ | RDTV

The Cincinnati Reds (+150) visit Wrigley Field to take on the Chicago Cubs (-185) on May 6, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Reds are 20-16 against the spread (ATS), while the Cubs are 17-19 ATS.

Reds vs Cubs Starting Pitchers Today:

• Reds starting pitcher: Brady Singer 2-2, 5.57 ERA
• Cubs starting pitcher: Colin Rea 4-1, 4.37 ERA

Reds vs. Cubs Odds, Run Line, Over/Under & Moneyline

Reds vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Wednesday‘s MLB game with 56.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Wednesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• JJ Bleday has hit the Home Runs Over in 4 of his last 8 games (+18.00 Units / 225% ROI)
• TJ Friedl has hit the Walks Under in 18 of his last 20 games (+15.25 Units / 44% ROI)
• Ke’Bryan Hayes has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+14.90 Units / 43% ROI)
• Tyler Stephenson has hit the Runs Under in 14 of his last 15 games (+12.45 Units / 42% ROI)
• Ke’Bryan Hayes has hit the Singles Under in 16 of his last 20 games (+10.60 Units / 38% ROI)

And here are some favorite MLB player prop bets for Cubs players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Michael Busch has hit the Home Runs Over in 3 of his last 7 games at home (+16.00 Units / 229% ROI)
• Ian Happ has hit the Walks Over in 16 of his last 20 games at home (+13.45 Units / 63% ROI)
• Carson Kelly has hit the Singles Over in 15 of his last 20 games (+11.45 Units / 56% ROI)
• Ian Happ has hit the Runs Over in 16 of his last 25 games at home (+10.45 Units / 38% ROI)
• Carson Kelly has hit the Hits Over in 16 of his last 20 games (+9.40 Units / 26% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Under in 29 of their last 50 away games (+8.35 Units / 15% ROI)
• The Cincinnati Reds have covered the Run Line in 22 of their last 35 games (+5.85 Units / 11% ROI)
• The Cincinnati Reds have hit the Moneyline in 28 of their last 50 games (+5.50 Units / 10% ROI)
• The Cincinnati Reds have hit the Team Total Under in 26 of their last 45 games (+5.15 Units / 10% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 26 of their last 45 games (+4.20 Units / 8% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Moneyline in 17 of their last 20 games (+14.75 Units / 57% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games at home (+12.05 Units / 23% ROI)
• The Chicago Cubs have hit the Team Total Over in 26 of their last 40 games (+11.00 Units / 24% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+9.65 Units / 12% ROI)
• The Chicago Cubs have hit the Game Total Over in 30 of their last 50 games (+9.25 Units / 17% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 22-13 against the Run Line (+4.6 Units / 8.47% ROI).

• 20-16 when betting on the Moneyline for +4.3 Units / 10.66% ROI
• 21-14 when betting on the total runs Over for +5.6 Units / 14.12% ROI
• 14-21 when betting on the total runs Under for -9.05 Units / -22.88% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 17-19 against the Run Line (-1.55 Units / -3.64% ROI).

• 24-12 when betting on the Moneyline for +8.4 Units / 16.8% ROI
• 22-13 when betting on the total runs Over for +7.95 Units / 20.03% ROI
• 13-22 when betting on the total runs Under for -11.1 Units / -28% ROI

Cubs vs Reds Home Run Prop Bets Today

Cubs vs Reds Total Hits Prop Bets Today

Cubs vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Cubs

The Reds are 3-14 (.176) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .056.

The Reds are just 10-62 (.139) when allowing 5 or more runs since the 2025 season — 5th lowest in MLB; League Avg: .205.

The Reds are 4-10 (.286) when trailing entering the 7th inning this season — tied for 3rd best in MLB; League Avg: .144.

The Reds are just 12-44 (.214) when allowing 10 or more hits since the 2025 season — 5th lowest in MLB; League Avg: .254.

Cubs Keys to the Game vs. the Reds

The Cubs are 45-9 (.833) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .634.

The Cubs are 4-11 (.267) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .110.

The Cubs are 4-9 (.308) when trailing entering the 7th inning this season — 2nd best in MLB; League Avg: .144.

The Cubs are 60-7 (.896) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .745.

Reds Hitting Stats & Trends

Reds hitters have an OBP of just .282 (588 PA’s) with runners on base this season — lowest in MLB.

The Reds are batting just .198 with runners on base this season — lowest in MLB.

Reds hitters have a swing rate of just 40% in lefty-lefty matchups since the 2025 season — lowest in MLB.

The Reds are batting just .193 with two outs this season — 2nd lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .406 (318 PA’s) when leading off an inning this season — best in MLB.

Cubs hitters have an OBP of .373 (466 PA’s) against LHP this season — best in MLB.

Cubs hitters have drawn walks in 15% of their PA’s when leading off an inning this season — best in MLB.

Cubs hitters are slugging .436 against LHP since the 2025 season — 3rd best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have walked 15% of batters over the past seven days (7 games) — highest in MLB.

Reds pitchers have walked 12% of batters this season — 2nd highest in MLB.

Opponents have a groundball rate of just 41% against Reds pitchers this season — 5th lowest in MLB.

Reds pitchers have a strikeout rate of just 20% this season — 4th lowest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers have walked 8% of batters this season — 4th best in MLB.

Opponents have a miss rate of just 24% against Cubs pitchers since the 2025 season — tied for 4th lowest in MLB.

Cubs pitchers walked 7% of batters in the 2025 season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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