• The Diamondbacks are -150 favorites vs the Reds
• Reds vs Diamondbacks Over / Under today: 8 Runs
• Reds / Diamondbacks TV Channel: DBTV | RDTV

The Cincinnati Reds (+125) visit Chase Field to take on the Arizona Diamondbacks (-150) on August 21, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the Reds are 61-67 against the spread (ATS), while the Diamondbacks are 68-56 ATS.

Reds vs Diamondbacks Starting Pitchers Today:

• Reds starting pitcher: Nick Lodolo 3-2, 4.50 ERA
• Diamondbacks starting pitcher: Eduardo Rodriguez 12-4, 2.71 ERA

Reds vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

Reds vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Friday‘s MLB game with 54.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Diamondbacks and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Friday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Eugenio Suarez has hit the Home Runs Over in 6 of his last 10 away games (+23.80 Units / 238% ROI)
• Tyler Stephenson has hit the Hits Over in 20 of his last 25 away games (+12.85 Units / 33% ROI)
• JJ Bleday has hit the RBIs Under in 21 of his last 25 games (+12.60 Units / 24% ROI)
• Tyler Stephenson has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+11.35 Units / 38% ROI)
• JJ Bleday has hit the Total Bases Under in 18 of his last 25 away games (+10.60 Units / 32% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Friday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Nolan Arenado has hit the Home Runs Over in 4 of his last 10 games at home (+18.40 Units / 184% ROI)
• Eduardo Rodriguez has hit the Earned Runs Under in 20 of his last 25 games (+15.15 Units / 53% ROI)
• Corbin Carroll has hit the Singles Under in 20 of his last 25 games at home (+12.95 Units / 36% ROI)
• Gabriel Moreno has hit the Hits Over in 19 of his last 25 games at home (+12.95 Units / 27% ROI)
• Gabriel Moreno has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.55 Units / 41% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 13 games (+9.20 Units / 58% ROI)
• The Cincinnati Reds have hit the Game Total Under in 26 of their last 45 games (+6.20 Units / 12% ROI)
• The Cincinnati Reds have hit the Team Total Under in 26 of their last 45 games (+4.95 Units / 10% ROI)
• The Cincinnati Reds have hit the Moneyline in 13 of their last 24 away games (+4.65 Units / 18% ROI)
• The Cincinnati Reds have covered the Run Line in 9 of their last 16 away games (+0.75 Units / 3% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Moneyline in 26 of their last 45 games (+11.10 Units / 22% ROI)
• The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 16 of their last 23 games at home (+8.70 Units / 33% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 31 of their last 50 games at home (+8.65 Units / 14% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 28 of their last 50 games at home (+8.35 Units / 15% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 23 of their last 45 games (+7.10 Units / 14% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 66-60 against the Run Line (-10 Units / -5.59% ROI).

• 61-67 when betting on the Moneyline for -5.75 Units / -4% ROI
• 67-59 when betting on the total runs Over for +2 Units / 1.41% ROI
• 59-67 when betting on the total runs Under for -14.2 Units / -10.12% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 68-56 against the Run Line (+0.55 Units / 0.32% ROI).

• 67-61 when betting on the Moneyline for +8.05 Units / 5.4% ROI
• 55-67 when betting on the total runs Over for -18.75 Units / -13.25% ROI
• 67-55 when betting on the total runs Under for +7.05 Units / 5.03% ROI

Diamondbacks vs Reds Home Run Prop Bets Today

Diamondbacks vs Reds Total Hits Prop Bets Today

Diamondbacks vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Diamondbacks

The Reds are 6-59 (.092) when trailing entering the 9th inning this season — 3rd best in MLB.

The Reds are just 7-17 (.292) when tied entering the 7th inning this season — 3rd lowest in MLB.

The Reds are 49-14 (.778) when allowing 4 or fewer runs this season — tied for 2nd best in MLB.

The Reds are just 30-16 (.652) when they’ve had 5 or more XBH since the 2025 season — 2nd lowest in MLB.

Diamondbacks Keys to the Game vs. the Reds

The Diamondbacks are 58-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks are just 109-25 (.813) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB.

The Diamondbacks are 8-117 (.064) when trailing entering the 9th inning since the 2025 season — 4th best in MLB.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

Reds Hitting Stats & Trends

The Reds are 6-59 (.092) when trailing entering the 9th inning this season — 3rd best in MLB.

The Reds are just 7-17 (.292) when tied entering the 7th inning this season — 3rd lowest in MLB.

The Reds are 35-25 (.583) against the run line (6.1% ROI) on the road this season — 3rd best in MLB.

The Reds are 49-14 (.778) when allowing 4 or fewer runs this season — tied for 2nd best in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are 35-28 (.556) against the run line (6.8% ROI) at home this season — 4th best in MLB.

Games involving the Diamondbacks went UNDER in 61% of their games (21.4% ROI) after a loss this season — 3rd highest in MLB.

The Diamondbacks are 70-58 (.547) against the run line (-0.3% ROI) this season — tied for 4th best in MLB.

The Diamondbacks are 31-22 (7.7% ROI) when slight moneyline favorites (-101 to -149) this season — 4th best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have walked 6 of 124 batters (5%) when facing the leadoff batter in the inning over the last 14 days (14 games) — tied for 3rd best in MLB; League Avg: 8%.

Reds pitchers have an ERA of 6.49 (51.1 IP) on the road this month (6 games) — 2nd highest in MLB; League Avg: 4.26.

Reds pitchers have walked 10 of 169 batters (6%) when facing the leadoff batter in the inning this month (19 games) — 2nd best in MLB; League Avg: 8%.

Reds pitchers have walked 3 of 73 batters (4%) when facing the leadoff batter in the inning over the past seven days (8 games) — 3rd best in MLB; League Avg: 9%.

Diamondbacks Pitching Stats & Trends

Opponents have a groundball rate of just 34% against Diamondbacks pitchers over the past seven days (6 games) — lowest in MLB; League Avg: 42%.

Opponents have a groundball rate of just 37% against Diamondbacks pitchers over the last 14 days (12 games) — 2nd lowest in MLB; League Avg: 42%.

Diamondbacks pitchers have a strikeout rate of just 16% over the past seven days (6 games) — 3rd lowest in MLB; League Avg: 22%.

Diamondbacks pitchers have walked 14 of 226 batters (6%) over the past seven days (6 games) — 2nd best in MLB; League Avg: 9%.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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