• The Reds are -110 favorites vs the Rays
• Reds vs Rays Over / Under today: 7.5 Runs
• Reds / Rays TV Channel: RDTV | RATV

The Cincinnati Reds (-110) visit Tropicana Field to take on the Tampa Bay Rays (-110) on April 21, 2026. First pitch is scheduled for 6:40 pm in St. Petersburg, FL.

This season, the Reds are 15-8 against the spread (ATS), while the Rays are 12-10 ATS.

Reds vs Rays Starting Pitchers Today:

• Reds starting pitcher: Chase Burns 1-1, 2.42 ERA
• Rays starting pitcher: Steven Matz 3-0, 3.86 ERA

Reds vs. Rays Odds, Run Line, Over/Under & Moneyline

Reds vs Rays Prediction for Today’s Game

Based on recent trends the model predicts the Rays will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Rays and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Tuesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Ke’Bryan Hayes has hit the Hits Runs and RBIs Under in 18 of his last 20 games (+17.30 Units / 62% ROI)
• Ke’Bryan Hayes has hit the Hits Under in 16 of his last 20 games (+14.75 Units / 74% ROI)
• Ke’Bryan Hayes has hit the Total Bases Under in 16 of his last 20 games (+14.25 Units / 71% ROI)
• Sal Stewart has hit the Home Runs Over in 3 of his last 6 away games (+12.00 Units / 200% ROI)
• Elly De La Cruz has hit the Runs Over in 16 of his last 25 games (+11.05 Units / 44% ROI)

And here are some favorite MLB player prop bets for Rays players for Tuesday‘s game, looking at profitable historical betting trends:

Best Rays Player Prop Best Bets Today:

• Yandy Diaz has hit the Walks Over in 10 of his last 15 games at home (+12.10 Units / 81% ROI)
• Chandler Simpson has hit the Singles Over in 17 of his last 20 games (+11.80 Units / 35% ROI)
• Chandler Simpson has hit the Hits Over in 14 of his last 20 games (+9.75 Units / 28% ROI)
• Jonathan Aranda has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+8.60 Units / 30% ROI)
• Junior Caminero has hit the Home Runs Over in 3 of his last 6 games (+7.75 Units / 129% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Moneyline in 27 of their last 45 games (+9.65 Units / 19% ROI)
• The Cincinnati Reds have hit the Game Total Under in 29 of their last 50 away games (+8.35 Units / 15% ROI)
• The Cincinnati Reds have covered the Run Line in 22 of their last 35 away games (+5.95 Units / 11% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 35 games (+5.10 Units / 12% ROI)
• The Cincinnati Reds have hit the Team Total Under in 26 of their last 45 games (+4.40 Units / 8% ROI)

Rays Best Bets Today:

• The Tampa Bay Rays have hit the Game Total Over in 29 of their last 50 games (+10.25 Units / 19% ROI)
• The Tampa Bay Rays have hit the Team Total Over in 25 of their last 40 games (+7.90 Units / 16% ROI)
• The Tampa Bay Rays have covered the 1st Five Innings (F5) Run Line in 15 of their last 23 games at home (+6.55 Units / 24% ROI)
• The Tampa Bay Rays have hit the 1st Five Innings (F5) Team Total Over in 29 of their last 50 games (+5.95 Units / 10% ROI)
• The Tampa Bay Rays have covered the Run Line in 14 of their last 23 games at home (+5.70 Units / 18% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 15-8 against the Run Line (+4.35 Units / 11.98% ROI).

• 15-8 when betting on the Moneyline for +7.9 Units / 31.6% ROI
• 12-10 when betting on the total runs Over for +1 Units / 3.95% ROI
• 10-12 when betting on the total runs Under for -3.2 Units / -12.65% ROI

Rays Against the Spread (ATS) Record

Against the spread this season, the Rays are 12-10 against the Run Line (+0.85 Units / 2.95% ROI).

• 12-10 when betting on the Moneyline for +2.05 Units / 8.27% ROI
• 14-6 when betting on the total runs Over for +7.35 Units / 30.56% ROI
• 6-14 when betting on the total runs Under for -9.65 Units / -39.63% ROI

Rays vs Reds Home Run Prop Bets Today

Rays vs Reds Total Hits Prop Bets Today

Rays vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Rays

The Reds are 2-8 (.200) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .052.

The Reds are 3-6 (.333) when trailing entering the 7th inning this season — tied for 2nd best in MLB; League Avg: .133.

The Reds are 9-2 (.818) on the road this season — best in MLB; League Avg: .454.

The Reds are 12-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .867.

Rays Keys to the Game vs. the Reds

The Rays are 9-0 (1.000) when allowing 4 or fewer runs this season — best in MLB; League Avg: .721.

The Rays are just 0-9 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .107.

The Rays were just 63-11 (.851) when leading entering the 8th inning in the 2025 season — 4th lowest in MLB; League Avg: .909.

The Rays are just 72-11 (.867) when leading entering the 8th inning since the 2025 season — 5th lowest in MLB; League Avg: .907.

Reds Hitting Stats & Trends

The Reds are batting just .183 at home this season — lowest in MLB.

Reds hitters are slugging just .320 against RHP this season — 2nd lowest in MLB.

Reds hitters have an OPS of just .620 (666 PA’s) against RHP this season — 2nd lowest in MLB.

Reds hitters have an OBP of just .270 (383 PA’s) with runners on base this season — lowest in MLB.

Rays Hitting Stats & Trends

Rays hitters have a Hard-Hit Rate of just 34% in non-two strike counts this season — lowest in MLB.

Rays hitters have struck out in just 18% of their PA’s against RHP this season — best in MLB.

Rays hitters have pulled just 40% of balls they’ve put into play this season — lowest in MLB.

Rays hitters have struck out in just 22% of their PA’s on pitches out of the zone this season — best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a strikeout rate of just 16% over the last 14 days — lowest in MLB.

Reds pitchers have a strikeout rate of just 20% this season — tied for 4th lowest in MLB.

Opponents had a groundball rate of just 40% against Reds pitchers in the 2025 season — tied for 3rd lowest in MLB.

Reds pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Rays Pitching Stats & Trends

Rays pitchers had a strikeout rate of 26% with runners in scoring position in the 2025 season — best in MLB.

Rays pitchers have a strikeout rate of just 18% versus hitters not batting 3-4-5 in the order this season — 2nd lowest in MLB.

Rays pitchers had a strikeout rate of 24% in the 2025 season — tied for 4th best in MLB.

Opponents have a groundball rate of just 39% against Rays pitchers this month (17 games) — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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