• The Rays are -140 favorites vs the Reds
• Reds vs Rays Over / Under today: 8.5 Runs
• Reds / Rays TV Channel: RDTV | RATV

The Cincinnati Reds (+115) visit Tropicana Field to take on the Tampa Bay Rays (-140) on April 22, 2026. First pitch is scheduled for 1:10 pm in St. Petersburg, FL.

This season, the Reds are 16-8 against the spread (ATS), while the Rays are 12-11 ATS.

Reds vs Rays Starting Pitchers Today:

• Reds starting pitcher: Brandon Williamson 2-1, 4.36 ERA
• Rays starting pitcher: Nick Martinez 0-1, 2.46 ERA

Reds vs. Rays Odds, Run Line, Over/Under & Moneyline

Reds vs Rays Prediction for Today’s Game

Based on recent trends the model predicts the Rays will win Wednesday‘s MLB game with 52.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Rays and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Wednesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Ke’Bryan Hayes has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+15.55 Units / 45% ROI)
• Ke’Bryan Hayes has hit the Hits Under in 18 of his last 25 games (+14.00 Units / 56% ROI)
• Ke’Bryan Hayes has hit the Total Bases Under in 18 of his last 25 games (+13.45 Units / 53% ROI)
• Elly De La Cruz has hit the Runs Over in 15 of his last 20 games (+13.10 Units / 65% ROI)
• Sal Stewart has hit the RBIs Over in 11 of his last 15 games (+11.70 Units / 78% ROI)

And here are some favorite MLB player prop bets for Rays players for Wednesday‘s game, looking at profitable historical betting trends:

Best Rays Player Prop Best Bets Today:

• Yandy Diaz has hit the Walks Over in 10 of his last 15 games at home (+12.10 Units / 81% ROI)
• Chandler Simpson has hit the Singles Over in 16 of his last 20 games (+9.10 Units / 27% ROI)
• Ben Williamson has hit the Hits Under in 12 of his last 20 games (+8.55 Units / 43% ROI)
• Junior Caminero has hit the Home Runs Over in 3 of his last 7 games (+6.75 Units / 96% ROI)
• Ben Williamson has hit the Total Bases Under in 15 of his last 25 games (+6.75 Units / 23% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Moneyline in 13 of their last 18 away games (+10.10 Units / 55% ROI)
• The Cincinnati Reds have hit the Game Total Under in 29 of their last 50 away games (+8.30 Units / 15% ROI)
• The Cincinnati Reds have covered the Run Line in 16 of their last 23 games (+7.15 Units / 20% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 14 of their last 22 away games (+4.75 Units / 18% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 5 of their last 8 games (+3.65 Units / 41% ROI)

Rays Best Bets Today:

• The Tampa Bay Rays have hit the Game Total Over in 30 of their last 50 games (+12.40 Units / 23% ROI)
• The Tampa Bay Rays have hit the Team Total Over in 31 of their last 50 games (+9.35 Units / 16% ROI)
• The Tampa Bay Rays have covered the 1st Five Innings (F5) Run Line in 15 of their last 24 games at home (+5.10 Units / 18% ROI)
• The Tampa Bay Rays have hit the Moneyline in 10 of their last 16 games (+4.20 Units / 23% ROI)
• The Tampa Bay Rays have covered the Run Line in 14 of their last 24 games at home (+3.95 Units / 12% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 16-8 against the Run Line (+5.9 Units / 15.82% ROI).

• 16-8 when betting on the Moneyline for +8.9 Units / 34.1% ROI
• 13-10 when betting on the total runs Over for +2 Units / 7.58% ROI
• 10-13 when betting on the total runs Under for -4.3 Units / -16.29% ROI

Rays Against the Spread (ATS) Record

Against the spread this season, the Rays are 12-11 against the Run Line (-0.9 Units / -2.95% ROI).

• 12-11 when betting on the Moneyline for +0.95 Units / 3.67% ROI
• 15-6 when betting on the total runs Over for +8.35 Units / 33.2% ROI
• 6-15 when betting on the total runs Under for -10.75 Units / -42.24% ROI

Rays vs Reds Home Run Prop Bets Today

Rays vs Reds Total Hits Prop Bets Today

Rays vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Rays

The Reds are 2-8 (.200) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .050.

The Reds are 10-2 (.833) on the road this season — best in MLB; League Avg: .462.

The Reds are 3-8 (.273) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .105.

The Reds were just 7-50 (.123) when they allowed 5 or more runs in the 2025 season — 3rd lowest in MLB; League Avg: .202.

Rays Keys to the Game vs. the Reds

The Rays are 9-0 (1.000) when allowing 4 or fewer runs this season — best in MLB; League Avg: .722.

The Rays are just 0-10 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .105.

The Rays are 9-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .866.

The Rays were just 57-14 (.803) when leading entering the 7th inning in the 2025 season — 4th lowest in MLB; League Avg: .875.

Reds Hitting Stats & Trends

The Reds are batting just .183 at home this season — lowest in MLB.

The Reds are batting just .177 with runners on base this season — lowest in MLB.

Reds hitters have a swing rate of just 39% in lefty-lefty matchups since the 2025 season — lowest in MLB.

The Reds are batting just .207 this season — lowest in MLB.

Rays Hitting Stats & Trends

Rays hitters have a Hard-Hit Rate of just 34% in non-two strike counts this season — lowest in MLB.

Rays hitters have struck out in just 18% of their PA’s against RHP this season — best in MLB.

Rays hitters have put 41% of their swings in play in non-two strike counts this season — highest in MLB.

Rays hitters have missed on just 20% of swings this season — best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a strikeout rate of just 16% over the last 14 days — lowest in MLB.

Reds pitchers have a strikeout rate of just 17% in the first 5 innings this season — 2nd lowest in MLB.

Reds pitchers have thrown at least two strikes in their first three pitches to 57% of opposing batters this season — lowest in MLB.

Opponents had a groundball batting average of just .228 against Reds pitchers in the 2025 season — 2nd best in MLB.

Rays Pitching Stats & Trends

Rays pitchers had a strikeout rate of 26% with runners in scoring position in the 2025 season — best in MLB.

Rays pitchers induced opposing hitters to ground into 128 double plays in 1,070 opportunities (12%) in the 2025 season — best in MLB.

Rays pitchers have a strikeout rate of 25% with runners in scoring position since the 2025 season — best in MLB.

Rays pitchers had a strikeout rate of 44% with two-strikes in the 2025 season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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