• The Royals are -105 favorites vs the Cardinals
• Royals vs Cardinals Over / Under today: 8.5 Runs
• Royals / Cardinals TV Channel: RYTV | CATV

The Kansas City Royals (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on May 15, 2026. First pitch is scheduled for 8:15 pm in St. Louis, MO.

This season, the Royals are 19-25 against the spread (ATS), while the Cardinals are 27-15 ATS.

Royals vs Cardinals Starting Pitchers Today:

• Royals starting pitcher: Michael Wacha 4-2, 2.65 ERA
• Cardinals starting pitcher: Dustin May 3-4, 4.97 ERA

Royals vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Royals vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Friday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Royals vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Royals players for Friday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Bets Today:

• Bobby Witt Jr. has hit the Home Runs Over in 5 of his last 10 games (+15.60 Units / 156% ROI)
• Isaac Collins has hit the Runs Under in 14 of his last 15 away games (+12.40 Units / 38% ROI)
• Carter Jensen has hit the Total Bases Under in 13 of his last 15 games (+11.60 Units / 55% ROI)
• Salvador Perez has hit the Hits Under in 14 of his last 25 away games (+10.70 Units / 40% ROI)
• Bobby Witt Jr. has hit the Singles Over in 18 of his last 25 away games (+9.55 Units / 31% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• JJ Wetherholt has hit the Home Runs Over in 3 of his last 10 games at home (+15.60 Units / 156% ROI)
• Jordan Walker has hit the Runs Over in 14 of his last 20 games at home (+14.10 Units / 70% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+11.15 Units / 42% ROI)
• Ivan Herrera has hit the Total Bases Over in 13 of his last 20 games (+9.30 Units / 41% ROI)
• Alec Burleson has hit the Hits Over in 13 of his last 15 games (+8.95 Units / 27% ROI)

Royals Best Bets Today:

• The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 21 away games (+11.20 Units / 47% ROI)
• The Kansas City Royals have hit the Game Total Under in 16 of their last 24 away games (+7.05 Units / 27% ROI)
• The Kansas City Royals have hit the Team Total Over in 14 of their last 22 games (+5.30 Units / 21% ROI)
• The Kansas City Royals have hit the Moneyline in 11 of their last 19 games (+1.70 Units / 8% ROI)
• The Kansas City Royals have covered the Run Line in 10 of their last 19 games (+1.70 Units / 7% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 28 of their last 50 games (+11.85 Units / 23% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 games at home (+9.85 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 14 of their last 25 games (+9.60 Units / 37% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 18 of their last 25 games (+8.90 Units / 28% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 14 of their last 22 games (+7.40 Units / 31% ROI)

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 19-24 against the Run Line (-8.05 Units / -13.9% ROI).

• 19-25 when betting on the Moneyline for -10.2 Units / -19.07% ROI
• 20-24 when betting on the total runs Over for -6.25 Units / -12.91% ROI
• 24-20 when betting on the total runs Under for +2.15 Units / 4.44% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 27-15 against the Run Line (+4.9 Units / 7.58% ROI).

• 25-18 when betting on the Moneyline for +11.85 Units / 27.12% ROI
• 19-21 when betting on the total runs Over for -4.2 Units / -8.89% ROI
• 21-19 when betting on the total runs Under for -0.15 Units / -0.32% ROI

Cardinals vs Royals Home Run Prop Bets Today

Cardinals vs Royals Total Hits Prop Bets Today

Cardinals vs Royals Strikeout Prop Bets Today

Royals Keys to the Game vs. the Cardinals

The Royals are just 14-4 (.778) when leading entering the 8th inning this season — lowest in MLB; League Avg: .895.

The Royals are just 1-11 (.083) when allowing 10 or more hits this season — tied for 2nd lowest in MLB; League Avg: .244.

The Royals are just 6-15 (.286) on the road this season — 2nd lowest in MLB; League Avg: .457.

The Royals are just 8-16 (.333) after a loss this season — tied for 2nd lowest in MLB; League Avg: .476.

Cardinals Keys to the Game vs. the Royals

The Cardinals are 3-15 (.167) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .051.

The Cardinals are just 6-9 (.400) vs bottom 10 scoring offenses this season Today, they face the Royals (21st in runs scored).

The Cardinals are 30-19 (.612) when tied entering the 7th inning since the 2024 season — 2nd best in MLB; League Avg: .499.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Royals Hitting Stats & Trends

33% of Royals hitters strikeouts have come on 95+ MPH fastballs this season — 2nd highest in MLB.

Royals hitters are slugging just .171 on pitches out of the zone this season — 3rd lowest in MLB.

Royals hitters have an OPS of .785 (874 PA’s) at home this season — 5th best in MLB.

Royals hitters are slugging just .219 with two-strikes this season — 3rd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — best in MLB.

Cardinals hitters have put 39% of their swings in play against LHP this season — tied for 4th highest in MLB.

Cardinals hitters are slugging .250 on pitches out of the zone this season — 4th best in MLB.

The Cardinals are batting just .209 with two outs this season — 4th lowest in MLB.

Royals Pitching Stats & Trends

Royals pitchers have walked 12% of batters this season — 4th highest in MLB.

Opponents have a groundball rate of just 39% against Royals pitchers this season — 3rd lowest in MLB.

Royals pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 5th highest in MLB.

Royals pitchers have picked-off 8 runners from first base this season — most in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Opponents have a groundball rate of 47% against Cardinals pitchers this season — 4th highest in MLB.

Cardinals pitchers have a strikeout rate of just 19% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 37% with two-strikes this season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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