• The Royals are +100 favorites vs the Cardinals
• Royals vs Cardinals Over / Under today: 9 Runs
• Royals / Cardinals TV Channel: RYTV | CATV

The Kansas City Royals (+100) visit Busch Stadium to take on the St. Louis Cardinals (-120) on May 16, 2026. First pitch is scheduled for 2:15 pm in St. Louis, MO.

This season, the Royals are 19-26 against the spread (ATS), while the Cardinals are 28-15 ATS.

Royals vs Cardinals Starting Pitchers Today:

• Royals starting pitcher: Noah Cameron 2-2, 5.56 ERA
• Cardinals starting pitcher: Kyle Leahy 4-3, 4.35 ERA

Royals vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Royals vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Saturday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Royals vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Royals players for Saturday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Bets Today:

• Michael Massey has hit the Home Runs Over in 2 of his last 6 games (+13.00 Units / 217% ROI)
• Isaac Collins has hit the Runs Under in 14 of his last 15 away games (+12.40 Units / 38% ROI)
• Carter Jensen has hit the Total Bases Under in 13 of his last 15 games (+11.60 Units / 55% ROI)
• Bobby Witt Jr. has hit the Hits Runs and RBIs Over in 15 of his last 20 games (+10.20 Units / 44% ROI)
• Michael Massey has hit the Singles Under in 19 of his last 25 games (+9.90 Units / 25% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Jordan Walker has hit the Runs Over in 17 of his last 25 games (+14.55 Units / 57% ROI)
• Pedro Pages has hit the Home Runs Over in 2 of his last 6 games at home (+14.00 Units / 233% ROI)
• Yohel Pozo has hit the Hits Under in 12 of his last 20 games (+9.10 Units / 43% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 16 of his last 25 games (+9.05 Units / 34% ROI)
• Victor Scott II has hit the Singles Under in 16 of his last 20 games (+8.75 Units / 25% ROI)

Royals Best Bets Today:

• The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 22 away games (+12.20 Units / 48% ROI)
• The Kansas City Royals have hit the Game Total Under in 16 of their last 25 away games (+5.95 Units / 21% ROI)
• The Kansas City Royals have hit the Team Total Under in 16 of their last 25 away games (+5.90 Units / 21% ROI)
• The Kansas City Royals have covered the Run Line in 10 of their last 20 games (+0.70 Units / 3% ROI)
• The Kansas City Royals have hit the Moneyline in 11 of their last 20 games (+0.60 Units / 3% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 24 of their last 40 games (+12.70 Units / 31% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 14 of their last 25 games (+9.60 Units / 37% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 18 of their last 25 games (+8.90 Units / 28% ROI)
• The St. Louis Cardinals have covered the Run Line in 14 of their last 18 games (+7.75 Units / 28% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 50 games at home (+7.40 Units / 13% ROI)

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 19-25 against the Run Line (-9.05 Units / -15.37% ROI).

• 19-26 when betting on the Moneyline for -11.3 Units / -20.7% ROI
• 21-24 when betting on the total runs Over for -5.25 Units / -10.61% ROI
• 24-21 when betting on the total runs Under for +1.05 Units / 2.12% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 28-15 against the Run Line (+5.9 Units / 8.89% ROI).

• 26-18 when betting on the Moneyline for +12.85 Units / 28.68% ROI
• 20-21 when betting on the total runs Over for -3.2 Units / -6.62% ROI
• 21-20 when betting on the total runs Under for -1.25 Units / -2.57% ROI

Cardinals vs Royals Home Run Prop Bets Today

Cardinals vs Royals Total Hits Prop Bets Today

Cardinals vs Royals Strikeout Prop Bets Today

Royals Keys to the Game vs. the Cardinals

The Royals are just 14-4 (.778) when leading entering the 8th inning this season — lowest in MLB; League Avg: .894.

The Royals are just 6-16 (.273) on the road this season — 2nd lowest in MLB; League Avg: .459.

The Royals are just 1-12 (.077) when allowing 10 or more hits this season — tied for 2nd lowest in MLB; League Avg: .243.

The Royals are just 2-9 (.182) vs top 10 scoring offenses this season Today, they face the Cardinals (ninth in runs scored).

Cardinals Keys to the Game vs. the Royals

The Cardinals are 3-15 (.167) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .051.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals are 31-19 (.620) when tied entering the 7th inning since the 2024 season — 2nd best in MLB; League Avg: .499.

Royals Hitting Stats & Trends

Royals hitters are slugging just .215 with two-strikes this season — 3rd lowest in MLB.

33% of Royals hitters strikeouts have come on 95+ MPH fastballs this season — 2nd highest in MLB.

Royals hitters have an OBP of just .285 (821 PA’s) on the road this season — tied for 2nd lowest in MLB.

Royals hitters have an OPS of just .448 (871 PA’s) with two-strikes this season — 2nd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — tied for best in MLB.

Cardinals hitters are slugging .252 on pitches out of the zone this season — 4th best in MLB.

Cardinals hitters have an OPS of .528 (924 PA’s) with two-strikes this season — 5th best in MLB.

The Cardinals are batting just .211 with two outs this season — 4th lowest in MLB.

Royals Pitching Stats & Trends

Royals pitchers have walked 12% of batters this season — 4th highest in MLB.

Royals pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Opponents have a groundball rate of just 40% against Royals pitchers this season — 3rd lowest in MLB.

Royals pitchers have allowed three-ball counts to 24% of batters they faced (412/1,704 PA’s) this season — 2nd highest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 37% with two-strikes this season — tied for lowest in MLB.

Cardinals pitchers have a strikeout rate of just 19% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — tied for lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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