Tigers vs Orioles Prediction, Odds & Player Prop Bets Today – MLB, Sep 21

min read
MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 21, 2022, 3:30 PM
  • The Orioles (76-71) are -150 favorites vs the Tigers (57-91)
  • Tigers starting pitcher: Matthew Manning (2-2), 3.27 ERA
  • Orioles starting pitcher: Jordan Lyles (10-11), 4.69 ERA
  • Watch the game on MASN

The Detroit Tigers (+125) visit Oriole Park at Camden Yards to take on the Baltimore Orioles (-150) on Wednesday, September 21, 2022. First pitch is scheduled for 7:05pm EDT in Baltimore.

The Orioles are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+135).

The Tigers vs Orioles Over/Under is 8.5 total runs for the game.

So far this season, the Tigers are 55-91 against the spread (ATS), while the Orioles are 90-55 ATS.

Tigers vs. Orioles Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Tigers+1.5 -160O 8.5 -115+125
Orioles -1.5 +135U 8.5 -105-150

Tigers vs Orioles Prediction for Today’s Game

Based on recent trends the model predicts the Orioles will win Wednesday‘s matchup with 61.7% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Tigers and Orioles and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on Orioles vs Tigers and all MLB games with BetMGM


Best Tigers Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Tigers players for Wednesday‘s game, looking at profitable historical betting trends:

  • Javier Baez has hit the Singles Over in 24 of his last 34 games (+12.40 Units / 30% ROI)
  • Miguel Cabrera has hit the Hits Under in 10 of his last 12 away games (+11.55 Units / 74% ROI)
  • Javier Baez has hit the Hits Over in 18 of his last 23 away games (+10.55 Units / 23% ROI)
  • Riley Greene has hit the Singles Over in 17 of his last 23 games (+9.75 Units / 33% ROI)
  • Victor Reyes has hit the Hits Over in 11 of his last 13 away games (+9.40 Units / 35% ROI)

Best Orioles Player Prop Best Bets Today

And here are some favorite MLB player prop bets for Orioles players for Wednesday‘s game, looking at profitable historical betting trends:

  • Ryan Mountcastle has hit the Total Bases Under in 42 of his last 60 games (+15.35 Units / 16% ROI)
  • Anthony Santander has hit the Total Bases Over in 29 of his last 50 games at home (+11.55 Units / 20% ROI)
  • Anthony Santander has hit the RBIs Under in his last 11 games (+11.00 Units / 49% ROI)
  • Ramon Urias has hit the Total Bases Under in 10 of his last 11 games (+9.70 Units / 54% ROI)
  • Ramon Urias has hit the Hits Under in 8 of his last 10 games (+9.30 Units / 78% ROI)

Orioles vs Tigers Home Run Prop Bets Today

Over Under
Adley Rutschman 0.5 +550 0.5 -1400
Austin Hays 0.5 +575 0.5 -1400
Cedric Mullins 0.5 +575 0.5 -1400
Gunnar Henderson 0.5 +500 0.5 -1100
Ramon Urias 0.5 +650 0.5 -2000

Orioles vs Tigers Total Hits Prop Bets Today

Over Under
Adley Rutschman 0.5 -275 0.5 +180
Austin Hays 0.5 -275 0.5 +190
Gunnar Henderson 0.5 -250 0.5 +175
Ramon Urias 0.5 -200 0.5 +140
Ryan Mountcastle 1.5 +185 1.5 -275

Orioles vs Tigers RBI Prop Bets Today

Over Under
Adley Rutschman 0.5 +175 0.5 -250
Austin Hays 0.5 +160 0.5 -225
Cedric Mullins 0.5 +190 0.5 -275
Gunnar Henderson 0.5 +160 0.5 -225
Ramon Urias 0.5 +185 0.5 -275

Orioles vs Tigers Strikeout Prop Bets Today

Over Under
Jordan Lyles 3.5 -145 3.5 +100
Matt Manning 3.5 +100 3.5 -145
  • The Detroit Tigers have hit the Game Total Under in 40 of their last 73 away games (+9.95 Units / 12% ROI)
  • The Detroit Tigers have covered the 1st Five Innings (F5) Run Line in 28 of their last 49 away games (+9.25 Units / 17% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Total Over in 28 of their last 48 away games (+8.90 Units / 17% ROI)
  • The Detroit Tigers have hit the Moneyline in 9 of their last 14 away games (+8.60 Units / 61% ROI)
  • The Detroit Tigers have covered the Run Line in 11 of their last 14 away games (+7.05 Units / 35% ROI)
  • The Baltimore Orioles have hit the 1st Five Innings (F5) Total Under in 45 of their last 80 games (+9.35 Units / 11% ROI)
  • The Baltimore Orioles have hit the Game Total Over in 3 of their last 5 games (+1.85 Units / 34% ROI)

Tigers Against the Spread (ATS) Record

Against the spread this MLB season, the Tigers have gone 67-78 against the Run Line (-22.25 Units / -12.16% ROI).

  • 55-91 when betting on the Moneyline for -17.65 Units / -11.52% ROI
  • 56-78 when betting on the total runs Over for -29.05 Units / -18.03% ROI
  • 78-56 when betting on the total runs Under for +17.35 Units / 10.79% ROI

Orioles Against the Spread (ATS) Record

Against the spread this MLB season, the Tigers have gone 90-55 against the Run Line (+24.6 Units / 12.91% ROI).

  • 76-70 when betting on the Moneyline for +25.7 Units / 16.15% ROI
  • 65-75 when betting on the total runs Over for -16.25 Units / -10.15% ROI
  • 75-65 when betting on the total runs Under for +3.65 Units / 2.25% ROI

Matt Manning has a first-pitch strike rate of just 46% (22/48) — lowest in MLB over the last two weeks; League Avg: 63% — first Percentile.

Left-handed hitters are hitting just .000 (0-for-21) against Matt Manning — best in MLB over the last two weeks; League Avg: .220 — 100th Percentile.

Matt Manning has allowed an OPS of just .186 (33 PA’s) vs left-handed batters this month (3 games) — best among qualified SPs in MLB; League Avg: .664 — 100th Percentile.

Matt Manning has allowed an OPS of just .045 (22 PA’s) vs left-handed batters — best in MLB over the last two weeks; League Avg: .653 — 100th Percentile.

Jordan Lyles: Orioles Starting Pitcher Stats & Trends

Jordan Lyles has allowed an OPS of .738 (359 PA’s) with two-strikes this season — highest among qualified SPs in MLB; League Avg: .464 — second Percentile.

Jordan Lyles has allowed an OBP of .315 (359 PA’s) with two-strikes this season — 2nd highest among qualified SPs in MLB; League Avg: .221 — fourth Percentile.

Jordan Lyles has allowed a slugging percentage of .423 (138 Total Bases / 326 ABs) with two-strikes this season — highest in MLB among starting pitchers with at least 73 total IP; League Avg: .265 — 0 Percentile.

Opponents are hitting .285 (184-for-646) against Jordan Lyles this season — 2nd highest among qualified SPs in MLB; League Avg: .235 — fourth Percentile.

Tigers Keys to the Game vs. the Orioles

The Tigers are just 6-31 (.162) when allowing 2 or more home runs this season — lowest in MLB; League Avg: .290.

The Tigers are just 6-63 (.087) when allowing 5 or more runs this season — lowest in MLB; League Avg: .199.

The Tigers are just 7-43 (.140) when allowing 10 or more hits this season — 2nd lowest in MLB; League Avg: .277.

The Tigers are just 30-45 (.400) at home this season — 5th lowest in MLB; League Avg: .527.

Orioles Keys to the Game vs. the Tigers

The Orioles are 25-6 (.806) when scoring in the first inning this season — 5th best in MLB; League Avg: .666.

The Orioles are 59-2 (.967) when leading entering the 8th inning this season — 2nd best in MLB; League Avg: .915.

The Orioles are 13-62 (.173) when trailing entering the 7th inning this season — 4th best in MLB; League Avg: .119.

The Orioles are just 13-25 (.342) when tied entering the 8th inning since the 2020 season — 3rd lowest in MLB; League Avg: .500.

Tigers hitters have an OBP of just .275 (3,936 PA’s) against RHP this season — lowest in MLB; League Avg: .311.

Tigers hitters have an OPS of just .602 (3,936 PA’s) against RHP this season — lowest in MLB; League Avg: .705.

Tigers hitters have an OBP of just .290 (2,680 PA’s) at home this season — 2nd lowest in MLB; League Avg: .316.

Tigers hitters have drawn 91 walks in 1,414 PA’s (6%) against LHP this season — lowest in MLB; League Avg: 8%.

The Orioles are batting just .224 against LHP this season — 5th lowest in MLB; League Avg: .245.

Orioles hitters are slugging just .202 at home over the last 14 days (6 games) — lowest in MLB; League Avg: .404.

Orioles hitters have an OBP of just .244 (172 PA’s) against LHP this month (12 games) — 2nd lowest in MLB; League Avg: .306.

The Orioles are batting just .172 against LHP this month (12 games) — lowest in MLB; League Avg: .240.

Tigers pitchers have a strikeout rate of just 20% since the start of last season — 5th lowest in MLB; League Avg: 23%.

The Tigers pitchers have allowed their opponents to score first in 60% of their games since the start of last season — highest in MLB; League Avg: 50%.

Tigers pitchers have walked 117 of 1,299 batters (9%) when facing the leadoff batter in the inning this season — tied for 2nd highest in MLB; League Avg: 7%.

The Tigers pitchers have allowed their opponents to score first in 59% of their games on the road this season — 2nd highest in MLB; League Avg: 46%.

Orioles pitchers have a strikeout rate of just 38% with two-strikes since the start of last season — lowest in MLB; League Avg: 43%.

Orioles pitchers have an ERA of 5.79 (1250.0 IP) against division opponents since the start of last season — highest in MLB; League Avg: 4.17.

Orioles pitchers have a strikeout rate of just 20% since the start of last season — tied for lowest in MLB; League Avg: 23%.

Opponents have a miss rate of just 24% against Orioles pitchers since the start of last season — 5th lowest in MLB; League Avg: 26%.

Orioles vs. Tigers Injuries Tonight That May Affect Prop Bets 

  • Christopher Ellis (Orioles): Shoulder, D60
  • John Means (Orioles): Elbow, D60
  • Casey Mize (Tigers): Elbow, D60
  • Jacob Rogers (Tigers): Elbow, D60
  • Rony García (Tigers): Bicep, D60
  • Tarik Skubal (Tigers): Arm, D60
  • Spencer Turnbull (Tigers): Elbow, D60
  • Austin Meadows (Tigers): Mental Health, D60
  • Beau Brieske (Tigers): Forearm, D60
  • Kyle Funkhouser (Tigers): Shoulder, D60

Looking for a risk-free bet up to $1,000? Bet now on Orioles vs Tigers and all MLB games with BetMGM


Bet on MLB Odds at BetMGM

At BetMGM, you can bet online with updated MLB betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.

About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.