Twins vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 28

(AP Photo/Ryan Sun)
  • The Guardians are -125 favorites vs the Twins
  • Twins vs Guardians Over / Under today: 8 Runs
  • Twins / Guardians TV Channel: GDTV | TWTV

The Minnesota Twins (+105) visit Progressive Field to take on the Cleveland Guardians (-125) on Monday, April 28, 2025. First pitch is scheduled for 6:10pm EDT in Cleveland, OH, OH.

This season, the Twins are 12-16 against the spread (ATS), while the Guardians are 14-13 ATS.

Twins vs Guardians Starting Pitchers Today:

  • Twins starting pitcher: Bailey Ober 2-1, 5.04 ERA
  • Guardians starting pitcher: Gavin Williams 2-1, 4.10 ERA

Twins vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Twins-1.5 +165O 8 -105+105
Guardians +1.5 -220U 8 -115-125

Twins vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Monday‘s MLB game with 51.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Twins players for Monday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

  • Ty France has hit the Home Runs Over in 2 of his last 5 away games (+13.50 Units / 270% ROI)
  • Ty France has hit the Hits Under in 14 of his last 25 away games (+11.85 Units / 47% ROI)
  • Ty France has hit the Singles Under in 18 of his last 25 away games (+10.65 Units / 38% ROI)
  • Brooks Lee has hit the Total Bases Under in his last 6 away games (+7.50 Units / 109% ROI)
  • Byron Buxton has hit the Runs Over in 13 of his last 20 games (+6.40 Units / 29% ROI)

And here are some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Kyle Manzardo has hit the Home Runs Over in 3 of his last 6 games (+14.60 Units / 243% ROI)
  • Kyle Manzardo has hit the Singles Under in 9 of his last 10 games at home (+7.15 Units / 38% ROI)
  • Kyle Manzardo has hit the Runs Over in 10 of his last 20 games (+6.45 Units / 32% ROI)
  • Kyle Manzardo has hit the RBIs Over in 5 of his last 7 games (+5.80 Units / 83% ROI)
  • Kyle Manzardo has hit the Hits Over in 7 of his last 8 games (+5.20 Units / 42% ROI)
  • The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 14 of their last 21 games (+7.75 Units / 30% ROI)
  • The Minnesota Twins have hit the Game Total Under in 13 of their last 19 games (+7.65 Units / 37% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 12 away games (+6.45 Units / 47% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 12 of their last 21 games (+6.45 Units / 22% ROI)
  • The Minnesota Twins have covered the Run Line in 11 of their last 18 games (+5.00 Units / 22% ROI)
  • The Cleveland Guardians have hit the Moneyline in 12 of their last 18 games (+6.95 Units / 31% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 27 games (+5.90 Units / 18% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 15 of their last 24 games (+5.30 Units / 19% ROI)
  • The Cleveland Guardians have hit the Game Total Over in 9 of their last 15 games (+4.60 Units / 28% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 9 of their last 17 games (+2.40 Units / 12% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 14-14 against the Run Line (+0.65 Units / 1.92% ROI).

  • 12-16 when betting on the Moneyline for -8.1 Units / -20.45% ROI
  • 10-15 when betting on the total runs Over for -6.6 Units / -21.29% ROI
  • 15-10 when betting on the total runs Under for +4 Units / 13.07% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 14-13 against the Run Line (-2.25 Units / -5.72% ROI).

  • 15-12 when betting on the Moneyline for +3.8 Units / 11.84% ROI
  • 14-11 when betting on the total runs Over for +2.3 Units / 7.81% ROI
  • 11-14 when betting on the total runs Under for -4.2 Units / -14.02% ROI

Guardians vs Twins Home Run Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +275 0.5 -350
Kyle Manzardo (CLE) 0.5 +350 0.5 -450
Jose Ramirez (CLE) 0.5 +375 0.5 -525
Carlos Santana (CLE) 0.5 +425 0.5 -625
Gabriel Arias (CLE) 0.5 +450 0.5 -650

Guardians vs Twins Total Hits Prop Bets Today

Over Under
Steven Kwan (CLE) 0.5 -250 0.5 +190
Carlos Correa (MIN) 0.5 -235 0.5 +180
Byron Buxton (MIN) 0.5 -210 0.5 +155
Jose Ramirez (CLE) 0.5 -210 0.5 +160
Ty France (MIN) 0.5 -200 0.5 +150

Guardians vs Twins RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +135 0.5 -185
Kyle Manzardo (CLE) 0.5 +145 0.5 -190
Byron Buxton (MIN) 0.5 +150 0.5 -200
Carlos Correa (MIN) 0.5 +160 0.5 -210
Trevor Larnach (MIN) 0.5 +190 0.5 -250

Guardians vs Twins Strikeout Prop Bets Today

Over Under
Gavin Williams (CLE) 5.5 -140 5.5 +105
Bailey Ober (MIN) 5.5 +130 5.5 -175

Opponents batted just .137 (40-for-293) against Bailey Ober’s non-fastballs in the 2024 season — best among qualified SPs in MLB; League Avg: .217 — 100th Percentile.

Opponents have a groundball rate of just 33% (182/548) against Bailey Ober since last season — lowest among qualified SPs in MLB; League Avg: 43% — first Percentile.

Opponents had a groundball rate of just 34% (161/469) against Bailey Ober in the 2024 season — 3rd lowest among qualified SPs in MLB; League Avg: 43% — fifth Percentile.

Bailey Ober has allowed a slugging percentage of .815 (22 Total Bases / 27 ABs) on breaking pitches this season — highest in MLB among starting pitchers with at least 10 total IP; League Avg: .376 — first Percentile.

Guardians Starting Pitcher Stats & Trends

Gavin Williams has a first-pitch strike rate of just 52% (57/110) this season — 4th lowest in MLB among starting pitchers with at least 10 total IP; League Avg: 62% — third Percentile.

Opponents had a groundball batting average of just .111 (3 GB hits out of 27 GBs) against Gavin Williams with runners in scoring position in 2023 — 2nd best in MLB among starting pitchers with at least 64 total IP; League Avg: .248 — 99th Percentile.

Gavin Williams has walked 22% of batters versus the 2-3-4 hitters this season — 4th highest in MLB among starting pitchers with at least 10 total IP; League Avg: 10% — third Percentile.

12 of Gavin Williams’ 51 breaking pitch strikeouts (23%) have been backdoor since last season — tied for 11th highest in MLB among starting pitchers with at least 75 total IP; League Avg: 14% — 90th Percentile.

Twins Keys to the Game vs. the Guardians

The Twins are just 16-33 (.327) vs top 10 scoring offenses since last season They play the Guardians (14th best runs scored) today.

The Twins are just 0-15 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .042.

The Twins are just 1-83 (.012) when trailing entering the 9th inning since last season — 2nd lowest in MLB; League Avg: .049.

The Twins are just 1-5 (.167) vs top 10 scoring offenses this season They play the Guardians (14th best runs scored) today.

Guardians Keys to the Game vs. the Twins

The Guardians are 85-3 (.966) when leading entering the 7th inning since last season — best in MLB; League Avg: .861.

The Guardians are 96-0 (1.000) when leading entering the 9th inning since last season — best in MLB; League Avg: .950.

The Guardians are 9-0 (1.000) when they’ve had 10 or more hits this season — tied for best in MLB; League Avg: .742.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

Twins hitters have struck out in 28% of it’s PA’s against LHP this season — 2nd highest in MLB; League Avg: 23%.

Twins hitters struck out 1,274 times in 4,710 PA’s (27%) against RHP in 2023 — highest in MLB; League Avg: 23%.

The Twins batted just .150 with two-strikes in the 2023 season — lowest in MLB; League Avg: .172.

Twins hitters slugged just .164 on pitches out of the zone in 2023 — 2nd lowest in MLB; League Avg: .211.

The Guardians batted just .232 against LHP in the 2023 season — tied for lowest in MLB; League Avg: .254.

Guardians hitters had an OPS of just .662 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .742.

Guardians hitters had an OBP of just .296 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .323.

Guardians hitters have an OPS of just .642 (3,980 PA’s) in innings 7-9 since the 2023 season — 2nd lowest in MLB; League Avg: .697.

Twins pitchers have walked 7% of batters this season — best in MLB; League Avg: 9%.

Opponents have a groundball rate of just 38% against Twins pitchers this season — 2nd lowest in MLB; League Avg: 43%.

Twins pitchers had a strikeout rate of 47% with two-strikes in 2023 — best in MLB; League Avg: 43%.

Opponents have a groundball rate of just 40% against Twins pitchers since last season — 2nd lowest in MLB; League Avg: 43%.

Opponents have a groundball batting average of just .216 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.