• The Guardians are -150 favorites vs the Twins
• Twins vs Guardians Over / Under today: 8 Runs
• Twins / Guardians TV Channel: GDTV | TWTV

The Minnesota Twins (+125) visit Progressive Field to take on the Cleveland Guardians (-150) on July 21, 2026. First pitch is scheduled for 6:40 pm in Cleveland, OH.

This season, the Twins are against the spread (ATS), while the Guardians are ATS.

Twins vs Guardians Starting Pitchers Today:

• Twins starting pitcher: Kendry Rojas 1-1, 2.84 ERA
• Guardians starting pitcher: Parker Messick 8-5, 2.76 ERA

Twins vs. Guardians Odds, Run Line, Over/Under & Moneyline

Twins vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 57.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Tuesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Josh Bell has hit the Total Bases Over in 18 of his last 25 away games (+15.80 Units / 54% ROI)
• Josh Bell has hit the Hits Over in 18 of his last 20 away games (+14.95 Units / 39% ROI)
• Luke Keaschall has hit the Home Runs Over in 2 of his last 7 away games (+13.00 Units / 186% ROI)
• Josh Bell has hit the RBIs Under in his last 10 games (+10.00 Units / 46% ROI)
• Kody Clemens has hit the Singles Under in 19 of his last 25 away games (+9.85 Units / 25% ROI)

And here are some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 3 of his last 9 games (+19.50 Units / 217% ROI)
• Chase DeLauter has hit the Hits Over in 21 of his last 25 games (+14.45 Units / 27% ROI)
• Chase DeLauter has hit the Singles Over in 16 of his last 20 games at home (+11.55 Units / 49% ROI)
• Brayan Rocchio has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+11.40 Units / 42% ROI)
• Chase DeLauter has hit the Walks Under in 17 of his last 20 games at home (+10.95 Units / 26% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Game Total Over in 30 of their last 45 away games (+15.60 Units / 32% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 30 away games (+11.80 Units / 32% ROI)
• The Minnesota Twins have hit the Team Total Over in 31 of their last 50 away games (+9.40 Units / 16% ROI)
• The Minnesota Twins have hit the Moneyline in 11 of their last 18 away games (+5.90 Units / 32% ROI)
• The Minnesota Twins have covered the Run Line in 10 of their last 16 away games (+2.85 Units / 12% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 24 games (+6.30 Units / 23% ROI)
• The Cleveland Guardians have covered the Run Line in 7 of their last 9 games (+5.00 Units / 38% ROI)
• The Cleveland Guardians have hit the Moneyline in 6 of their last 8 games (+4.00 Units / 45% ROI)
• The Cleveland Guardians have hit the Game Total Over in 8 of their last 12 games at home (+3.65 Units / 28% ROI)
• The Cleveland Guardians have hit the Team Total Under in 28 of their last 50 games (+3.20 Units / 5% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Guardians vs Twins Home Run Prop Bets Today

Guardians vs Twins Total Hits Prop Bets Today

Guardians vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the Guardians

The Twins are just 12-19 (.387) vs the bottom 10 runs allowed teams this season Today, they face the Guardians (eighth runs allowed).

The Twins are just 0-45 (.000) when trailing entering the 9th inning this season — lowest in MLB; League Avg: .053.

The Twins are just 0-42 (.000) when trailing entering the 8th inning this season — lowest in MLB; League Avg: .098.

The Twins are just 4-39 (.093) when trailing entering the 7th inning this season — 5th lowest in MLB; League Avg: .136.

Guardians Keys to the Game vs. the Twins

The Guardians are 18-4 (.818) when they’ve hit 2 or more home runs this season — tied for 2nd best in MLB; League Avg: .697.

The Guardians are 28-20 (.583) after a loss this season — 5th best in MLB; League Avg: .485.

The Guardians are 21-16 (.568) vs the top 10 runs allowed teams this season Today, they face Twins (26th in runs allowed).

The Guardians are 38-3 (.927) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .864.

Twins Hitting Stats & Trends

The Twins are batting just .289 on the first pitch of at-bats this season — lowest in MLB.

Twins hitters have an OPS of .758 (2,708 PA’s) against RHP this season — 4th best in MLB.

Twins hitters are slugging .436 against RHP this season — 3rd best in MLB.

Twins hitters have an OPS of just .680 (1,119 PA’s) against LHP this season — 4th lowest in MLB.

Guardians Hitting Stats & Trends

The Guardians are batting just .218 on the road this season — lowest in MLB.

Guardians hitters have an OBP of just .265 (428 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Guardians are batting just .196 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Guardians hitters have an OBP of just .237 (258 PA’s) against pitchers who have thrown at least 80 pitches in a game this season — lowest in MLB.

Twins Pitching Stats & Trends

Opponents have a groundball rate of just 39% against Twins pitchers this season — tied for 2nd lowest in MLB.

Twins pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 3rd highest in MLB.

The Twins have allowed 5.64 runs per game (282/50) on the road this season — highest in MLB.

Opponents have a groundball batting average of .294 against Twins pitchers with runners on base this season — highest in MLB.

Guardians Pitching Stats & Trends

Opponents have a miss rate of 27% against Guardians pitchers this season — 4th best in MLB.

Guardians pitchers have a strikeout rate of 24% this season — 4th best in MLB.

Guardians pitchers have allowed innings of 3+ runs in 4% of innings played this season — lowest in MLB.

Guardians pitchers have a strikeout rate of 25% with runners in scoring position this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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