• The Twins are -135 favorites vs the Nationals
• Twins vs Nationals Over / Under today: 9 Runs
• Twins / Nationals TV Channel: TWTV | NATV | ESUN

The Minnesota Twins (-135) visit Nationals Park to take on the Washington Nationals (+110) on May 6, 2026. First pitch is scheduled for 6:45 pm in Washington, D.C., DC.

This season, the Twins are 16-20 against the spread (ATS), while the Nationals are 20-15 ATS.

Twins vs Nationals Starting Pitchers Today:

• Twins starting pitcher: Bailey Ober 3-1, 3.56 ERA
• Nationals starting pitcher: Miles Mikolas 0-3, 8.24 ERA

Twins vs. Nationals Odds, Run Line, Over/Under & Moneyline

Twins vs Nationals Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Wednesday‘s MLB game with 58.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs Nationals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Brooks Lee has hit the Home Runs Over in 4 of his last 10 away games (+28.00 Units / 280% ROI)
• Austin Martin has hit the Walks Over in 14 of his last 20 games (+13.65 Units / 68% ROI)
• Brooks Lee has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.75 Units / 38% ROI)
• Byron Buxton has hit the Singles Under in 16 of his last 20 away games (+9.95 Units / 33% ROI)
• Brooks Lee has hit the Total Bases Over in 18 of his last 25 games (+9.30 Units / 26% ROI)

And here are some favorite MLB player prop bets for Nationals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Best Bets Today:

• Daylen Lile has hit the Home Runs Over in 3 of his last 10 games at home (+21.50 Units / 215% ROI)
• Daylen Lile has hit the Hits Under in 8 of his last 10 games (+9.25 Units / 72% ROI)
• Jorbit Vivas has hit the Total Bases Over in 15 of his last 20 games (+8.80 Units / 33% ROI)
• James Wood has hit the Singles Under in 15 of his last 20 games (+7.95 Units / 26% ROI)
• Curtis Mead has hit the Hits Runs and RBIs Over in 8 of his last 9 games at home (+7.65 Units / 73% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Team Total Over in 23 of their last 35 games (+9.40 Units / 22% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 22 of their last 40 games (+8.90 Units / 20% ROI)
• The Minnesota Twins have hit the Game Total Over in 15 of their last 23 games (+8.35 Units / 33% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 away games (+7.75 Units / 13% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 24 of their last 40 games (+6.15 Units / 13% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 33 of their last 50 games (+14.00 Units / 23% ROI)
• The Washington Nationals have hit the Game Total Over in 24 of their last 40 games (+8.95 Units / 20% ROI)
• The Washington Nationals have hit the Team Total Over in 28 of their last 45 games (+8.65 Units / 16% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 11 of their last 16 games (+5.40 Units / 27% ROI)
• The Washington Nationals have hit the Moneyline in 20 of their last 45 games (+4.95 Units / 11% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 18-18 against the Run Line (-6.75 Units / -12.98% ROI).

• 16-20 when betting on the Moneyline for -2.55 Units / -6.69% ROI
• 20-13 when betting on the total runs Over for +5.6 Units / 14.14% ROI
• 13-20 when betting on the total runs Under for -9.1 Units / -22.98% ROI

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 20-15 against the Run Line (+1 Units / 2.06% ROI).

• 16-20 when betting on the Moneyline for +3.1 Units / 8.53% ROI
• 22-12 when betting on the total runs Over for +9.05 Units / 23% ROI
• 12-22 when betting on the total runs Under for -12.35 Units / -30.95% ROI

Nationals vs Twins Home Run Prop Bets Today

Nationals vs Twins Total Hits Prop Bets Today

Nationals vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the Nationals

The Twins are just 6-23 (.207) when tied entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .500.

The Twins are just 4-84 (.045) when trailing entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .094.

The Twins are just 10-49 (.169) when allowing 2 or more home runs since the 2025 season — 2nd lowest in MLB; League Avg: .301.

The Twins are just 86-88 (.494) when allowing 5 or more extra base hits since the 2025 season — 5th lowest in MLB; League Avg: .534.

Nationals Keys to the Game vs. the Twins

The Nationals are just 35-62 (.357) at home since the 2025 season — 2nd lowest in MLB; League Avg: .541.

The Nationals are just 13-51 (.200) when their opponents score in the first inning since the 2025 season — lowest in MLB; League Avg: .365.

The Nationals are 8-2 (.800) when tied entering the 8th inning since the 2025 season — best in MLB; League Avg: .500.

The Nationals are just 4-13 (.235) at home this season — lowest in MLB; League Avg: .537.

Twins Hitting Stats & Trends

The Twins are batting just .128 on pitches out of the zone since the 2025 season — 2nd lowest in MLB.

Twins hitters have been successful in just 60% of their sacrifice bunt attempts since the 2025 season — 2nd lowest in MLB.

Twins hitters have chased 26% of pitches out of the zone against LHP this season — 2nd lowest in MLB.

Twins hitters are slugging just .169 on pitches out of the zone since the 2025 season — 2nd lowest in MLB.

Nationals Hitting Stats & Trends

The Nationals are batting just .161 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Nationals hitters have an OPS of .779 (424 PA’s) against LHP this season — 5th best in MLB.

Nationals hitters have an OBP of just .249 (173 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Nationals are batting .274 against LHP this season — 4th best in MLB.

Twins Pitching Stats & Trends

Opponents have a groundball rate of just 39% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 17% over the last 14 days — lowest in MLB.

Opponents have a groundball rate of just 39% against Twins pitchers since the 2025 season — 2nd lowest in MLB.

Opponents have a miss rate of just 22% against Twins pitchers this season — tied for 3rd lowest in MLB.

Nationals Pitching Stats & Trends

Nationals pitchers have an ERA of 5.27 (1749.2 IP) since the 2025 season — 2nd highest in MLB.

Nationals pitchers have a strikeout rate of just 19% this season — 2nd lowest in MLB.

Nationals pitchers have a strikeout rate of just 38% with two-strikes since the 2025 season — 2nd lowest in MLB.

The Nationals have allowed 6.94 runs per game (118/17) at home this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Twins vs Nationals and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.