• The Padres are -160 favorites vs the Twins
• Twins vs Padres Over / Under today: 8.5 Runs
• Twins / Padres TV Channel: TWTV | PDTV | KFMB

The Minnesota Twins (+135) visit Petco Park to take on the San Diego Padres (-160) on August 22, 2026. First pitch is scheduled for 8:40 pm in San Diego, CA.

This season, the Twins are 63-66 against the spread (ATS), while the Padres are 70-57 ATS.

Twins vs Padres Starting Pitchers Today:

• Twins starting pitcher: Dean Kremer 2-4, 5.47 ERA
• Padres starting pitcher: Casey Mize 5-7, 3.18 ERA

Twins vs. Padres Odds, Run Line, Over/Under & Moneyline

Twins vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Saturday‘s MLB game with 57.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Saturday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Luke Keaschall has hit the Hits Over in 22 of his last 25 away games (+16.80 Units / 38% ROI)
• Luke Keaschall has hit the Hits Runs and RBIs Over in 19 of his last 25 away games (+15.55 Units / 56% ROI)
• Luke Keaschall has hit the Total Bases Over in 19 of his last 25 away games (+13.50 Units / 37% ROI)
• Luke Keaschall has hit the Singles Over in 19 of his last 25 away games (+13.20 Units / 49% ROI)
• Trevor Larnach has hit the Home Runs Over in 3 of his last 9 away games (+12.50 Units / 139% ROI)

And here are some favorite MLB player prop bets for Padres players for Saturday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Jackson Merrill has hit the Home Runs Over in 4 of his last 8 games at home (+16.60 Units / 208% ROI)
• Luis Campusano has hit the Runs Under in 18 of his last 20 games (+13.55 Units / 33% ROI)
• Fernando Tatis Jr. has hit the Singles Under in 18 of his last 25 games (+11.40 Units / 42% ROI)
• Ty France has hit the Hits Over in 17 of his last 20 games at home (+11.40 Units / 29% ROI)
• Jackson Merrill has hit the Hits Runs and RBIs Over in 18 of his last 25 games at home (+10.35 Units / 36% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Game Total Over in 29 of their last 50 away games (+11.15 Units / 20% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Over in 22 of their last 35 away games (+7.70 Units / 18% ROI)
• The Minnesota Twins have covered the Run Line in 28 of their last 45 away games (+6.30 Units / 9% ROI)
• The Minnesota Twins have hit the Team Total Under in 29 of their last 50 games (+5.05 Units / 9% ROI)
• The Minnesota Twins have hit the Moneyline in 24 of their last 45 games (+3.20 Units / 6% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 22 of their last 35 games (+11.10 Units / 25% ROI)
• The San Diego Padres have hit the Moneyline in 21 of their last 30 games at home (+10.85 Units / 29% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 25 games at home (+9.25 Units / 33% ROI)
• The San Diego Padres have hit the Team Total Over in 22 of their last 35 games (+8.10 Units / 21% ROI)
• The San Diego Padres have hit the Game Total Under in 26 of their last 45 games at home (+7.40 Units / 15% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 70-58 against the Run Line (-2.8 Units / -1.53% ROI).

• 63-66 when betting on the Moneyline for -1.25 Units / -0.87% ROI
• 67-53 when betting on the total runs Over for +7.95 Units / 5.58% ROI
• 53-67 when betting on the total runs Under for -20.85 Units / -14.76% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 70-57 against the Run Line (+8.65 Units / 5.07% ROI).

• 69-60 when betting on the Moneyline for +5.05 Units / 3.31% ROI
• 56-69 when betting on the total runs Over for -19.95 Units / -14% ROI
• 69-56 when betting on the total runs Under for +7.75 Units / 5.48% ROI

Padres vs Twins Home Run Prop Bets Today

Padres vs Twins Total Hits Prop Bets Today

Padres vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the Padres

The Twins are just 11-8 (.579) when they’ve had 5 or more XBH this season — lowest in MLB.

The Twins are just 24-18 (.571) when they’ve hit 2 or more home runs this season — 3rd lowest in MLB.

The Twins are just 19-24 (.442) vs the bottom 10 runs allowed teams this season Today, they face the Padres (ninth fewest runs allowed).

The Twins are just 10-30 (.250) when tied entering the 7th inning since the 2025 season — lowest in MLB.

Padres Keys to the Game vs. the Twins

The Padres are 56-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Padres are 22-16 (.579) vs the top 10 runs allowed teams this season Today, they face Twins (26th fewest runs allowed).

The Padres are 10-51 (.164) when trailing entering the 7th inning this season — 4th best in MLB.

The Padres are 34-26 (.567) after a loss this season — 5th best in MLB.

Twins Hitting Stats & Trends

The Twins are batting just .294 on the first pitch of at-bats this season — lowest in MLB.

Twins hitters are slugging just .535 on the first pitch of at-bats this season — 5th lowest in MLB.

Twins hitters have 73 extra-base hits out of 165 total hits (44%) on the first pitch of at-bats this season — best in MLB.

Twins hitters have a 51% QAB rate with runners in scoring position this season — best in MLB.

Padres Hitting Stats & Trends

The Padres have answered-back in 38% of innings after an opponent scores in late innings this season — highest in MLB.

Padres hitters have put just 33% of balls in play to the right side of the field this season — lowest in MLB.

Padres hitters have an OPS of just .683 (2,316 PA’s) at home this season — 4th lowest in MLB.

The Padres are batting .251 with two outs this season — 3rd best in MLB.

Twins Pitching Stats & Trends

Twins pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Twins pitchers have an ERA of 5.10 (542.0 IP) on the road this season — 2nd highest in MLB.

The Twins have allowed 5.41 runs per game (341/63) on the road this season — highest in MLB.

In games when their opponents have scored three or more runs in an inning, the Twins have still managed to win 32% of the time this season — 5th highest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball batting average of .266 against Padres pitchers this season — tied for 3rd highest in MLB.

Padres pitchers have allowed an exit velocity over 100 MPH 668 times this season — 4th fewest in MLB.

Padres pitchers have allowed innings of 3+ runs in 5% of innings played this season — tied for 4th lowest in MLB.

Padres pitchers have a strikeout rate of 28% in close and late situations this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Twins vs Padres and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.