Washington Nationals vs San Diego Padres Prediction, Odds & Player Prop Bets Today – MLB, Jun 25

  • The San Diego Padres are -150 favorites vs the Washington Nationals
  • Washington Nationals vs San Diego Padres Over / Under today: 7.5 Runs
  • Washington Nationals / San Diego Padres TV Channel: MAS2 | PDTV

The Washington Nationals (+125) visit Petco Park to take on the San Diego Padres (-150) on Wednesday, June 25, 2025. First pitch is scheduled for 4:10pm EDT in San Diego, CA, CA.

This season, the Washington Nationals are 33-47 against the spread (ATS), while the San Diego Padres are 42-37 ATS.

Washington Nationals vs San Diego Padres Starting Pitchers Today:

  • Washington Nationals starting pitcher: , ERA
  • San Diego Padres starting pitcher: , ERA

Washington Nationals vs. San Diego Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Washington Nationals+1.5 -165O 7.5 -118+125
San Diego Padres -1.5 +140U 7.5 -102-150

Washington Nationals vs San Diego Padres Prediction for Today’s Game

Based on recent trends the model predicts the will win Wednesday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Washington Nationals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Washington Nationals Player Prop Bets Today:

  • Nate Lowe has hit the Home Runs Over in 3 of his last 8 away games (+13.90 Units / 174% ROI)
  • CJ Abrams has hit the Runs Over in 16 of his last 20 away games (+13.35 Units / 62% ROI)
  • Luis Garcia has hit the Total Bases Over in 15 of his last 20 away games (+13.05 Units / 58% ROI)
  • James Wood has hit the Hits Over in 20 of his last 25 away games (+10.95 Units / 24% ROI)
  • MacKenzie Gore has hit the Earned Runs Under in 18 of his last 25 games (+10.70 Units / 33% ROI)

And here are some favorite MLB player prop bets for San Diego Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best San Diego Padres Player Prop Best Bets Today:

  • Luis Arraez has hit the Singles Over in 22 of his last 25 games at home (+16.30 Units / 33% ROI)
  • Fernando Tatis Jr. has hit the Hits Under in 17 of his last 20 games at home (+12.65 Units / 30% ROI)
  • Gavin Sheets has hit the Total Bases Over in 14 of his last 15 games (+12.50 Units / 53% ROI)
  • Fernando Tatis Jr. has hit the RBIs Under in 21 of his last 25 games (+11.30 Units / 19% ROI)
  • Elias Diaz has hit the Home Runs Over in 1 of his last 4 games (+8.00 Units / 200% ROI)
  • The Washington Nationals have hit the Team Total Under in 39 of their last 64 games (+11.34 Units / 15% ROI)
  • The Washington Nationals have covered the Run Line in 17 of their last 23 away games (+10.95 Units / 37% ROI)
  • The Washington Nationals have hit the 1st Five Innings (F5) Team Total Under in 32 of their last 54 games (+8.87 Units / 14% ROI)
  • The Washington Nationals have hit the Moneyline in 13 of their last 25 away games (+7.90 Units / 31% ROI)
  • The Washington Nationals have hit the Game Total Over in 11 of their last 16 away games (+6.55 Units / 37% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 37 games (+10.10 Units / 23% ROI)
  • The San Diego Padres have hit the Game Total Under in 38 of their last 65 games (+9.40 Units / 13% ROI)
  • The San Diego Padres have hit the Team Total Over in 24 of their last 38 games at home (+8.75 Units / 20% ROI)
  • The San Diego Padres have covered the Run Line in 20 of their last 36 games at home (+6.90 Units / 17% ROI)
  • The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 21 of their last 36 games at home (+4.15 Units / 10% ROI)

Washington Nationals Against the Spread (ATS) Record

Against the spread this season, the Washington Nationals are 40-40 against the Run Line (-6.8 Units / -6.7% ROI).

  • 33-47 when betting on the Moneyline for -7.47 Units / -8.64% ROI
  • 37-40 when betting on the total runs Over for -6.8 Units / -7.72% ROI
  • 40-37 when betting on the total runs Under for -0.55 Units / -0.63% ROI

San Diego Padres Against the Spread (ATS) Record

Against the spread this season, the San Diego Padres are 42-37 against the Run Line (+0.75 Units / 0.73% ROI).

  • 43-36 when betting on the Moneyline for +1.25 Units / 1.18% ROI
  • 33-44 when betting on the total runs Over for -14.9 Units / -17.24% ROI
  • 44-33 when betting on the total runs Under for +7.55 Units / 8.62% ROI

San Diego Padres vs Washington Nationals Home Run Prop Bets Today

Over Under
James Wood (WAS) 0.5 +350 0.5 -450
Manny Machado (SD) 0.5 +350 0.5 -450
Fernando Tatis Jr. (SD) 0.5 +400 0.5 -550
CJ Abrams (WAS) 0.5 +475 0.5 -650
Josh Bell (WAS) 0.5 +500 0.5 -750

San Diego Padres vs Washington Nationals Total Hits Prop Bets Today

Over Under
Manny Machado (SD) 0.5 -250 0.5 +190
Fernando Tatis Jr. (SD) 0.5 -250 0.5 +185
Luis Garcia (WAS) 0.5 -220 0.5 +165
Xander Bogaerts (SD) 0.5 -210 0.5 +155
Jose Iglesias (SD) 0.5 -210 0.5 +160

San Diego Padres vs Washington Nationals RBI Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +140 0.5 -185
Luis Garcia (WAS) 0.5 +170 0.5 -225
Jackson Merrill (SD) 0.5 +170 0.5 -225
Luis Arraez (SD) 0.5 +175 0.5 -235
Fernando Tatis Jr. (SD) 0.5 +185 0.5 -250

San Diego Padres vs Washington Nationals Strikeout Prop Bets Today

Over Under
Nick Pivetta (SD) 5.5 -160 5.5 +120
Mackenzie Gore (WAS) 5.5 +110 5.5 -150

starting pitcher – away

San Diego Padres Starting Pitcher Stats & Trends

starting pitcher – home

Washington Nationals Keys to the Game vs. the San Diego Padres

keys to the game – away

San Diego Padres Keys to the Game vs. the Washington Nationals

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.