• The White Sox are -115 favorites vs the Cardinals
• White Sox vs Cardinals Over / Under today: 8 Runs
• White Sox / Cardinals TV Channel: CHSN | CATV | KMOV

The Chicago White Sox (-115) visit Busch Stadium to take on the St. Louis Cardinals (-105) on September 11, 2026. First pitch is scheduled for 8:15 pm in St. Louis, MO.

This season, the White Sox are 75-71 against the spread (ATS), while the Cardinals are 80-64 ATS.

White Sox vs Cardinals Starting Pitchers Today:

• White Sox starting pitcher: Anthony Kay 9-8, 4.46 ERA
• Cardinals starting pitcher: Matthew Liberatore 5-14, 5.59 ERA

White Sox vs. Cardinals Odds, Run Line, Over/Under & Moneyline

White Sox vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Friday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Miguel Vargas has hit the Walks Over in 17 of his last 25 games (+15.25 Units / 61% ROI)
• Randal Grichuk has hit the Total Bases Over in 13 of his last 15 games (+12.60 Units / 66% ROI)
• Randal Grichuk has hit the Hits Over in 14 of his last 15 games (+12.20 Units / 49% ROI)
• Miguel Vargas has hit the Singles Over in 16 of his last 25 games (+10.90 Units / 44% ROI)
• Munetaka Murakami has hit the Hits Runs and RBIs Under in 16 of his last 20 games (+10.85 Units / 43% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Nathan Church has hit the Hits Over in 21 of his last 25 games (+14.70 Units / 34% ROI)
• Nathan Church has hit the Singles Over in 18 of his last 25 games (+11.90 Units / 45% ROI)
• Ramon Urias has hit the Home Runs Over in 2 of his last 4 games (+11.30 Units / 283% ROI)
• Joshua Baez has hit the Hits Runs and RBIs Over in his last 10 games (+11.00 Units / 92% ROI)
• Matthew Liberatore has hit the Earned Runs Over in 15 of his last 20 games (+10.00 Units / 43% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 50 away games (+9.80 Units / 16% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 23 of their last 35 away games (+8.65 Units / 20% ROI)
• The Chicago White Sox have hit the Team Total Under in 9 of their last 12 games (+5.60 Units / 40% ROI)
• The Chicago White Sox have hit the Game Total Under in 7 of their last 9 away games (+4.80 Units / 48% ROI)
• The Chicago White Sox have covered the Run Line in 21 of their last 35 away games (+4.65 Units / 9% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 19 of their last 25 games (+13.65 Units / 50% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 22 of their last 40 games (+13.00 Units / 28% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 21 of their last 30 games (+10.25 Units / 28% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 22 of their last 35 games (+9.40 Units / 23% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 23 of their last 35 games (+9.25 Units / 23% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 81-62 against the Run Line (+3.8 Units / 1.84% ROI).

• 75-71 when betting on the Moneyline for +9.75 Units / 6.14% ROI
• 81-63 when betting on the total runs Over for +11.65 Units / 7.27% ROI
• 63-81 when betting on the total runs Under for -26.4 Units / -16.41% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 80-64 against the Run Line (+1.35 Units / 0.67% ROI).

• 72-75 when betting on the Moneyline for +3.75 Units / 2.34% ROI
• 67-73 when betting on the total runs Over for -13.65 Units / -8.43% ROI
• 73-67 when betting on the total runs Under for -0.85 Units / -0.53% ROI

White Sox Keys to the Game vs. the Cardinals

The White Sox are 14-5 (.737) when tied entering the 7th inning this season — 2nd best in MLB.

The White Sox are 23-27 (.460) when their opponents score in the first inning this season — 3rd best in MLB.

The White Sox are just 29-14 (.674) when they’ve had 10 or more hits this season — 3rd lowest in MLB.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

Cardinals Keys to the Game vs. the White Sox

The Cardinals are just 27-17 (.614) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 6-13 (.316) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are just 13-24 (.351) when tied entering the 8th inning since the 2025 season — 2nd lowest in MLB.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

White Sox Hitting Stats & Trends

White Sox hitters have 68 extra-base hits out of 140 total hits (49%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

White Sox hitters have grounded into 66 double plays in 1,044 opportunities (6%) this season — best in MLB.

White Sox hitters have struck out in 24% of their PA’s against RHP this season — tied for 4th highest in MLB.

White Sox hitters have 128 extra-base hits out of 326 total hits (39%) against LHP this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have an OPS of just .666 (2,633 PA’s) at home this season — 2nd lowest in MLB.

The Cardinals are batting .283 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

Cardinals hitters have 261 extra-base hits out of 844 total hits (just 31%) against RHP this season — 3rd lowest in MLB.

Cardinals hitters have an OPS of .734 (2,966 PA’s) on the road this season — 4th best in MLB.

White Sox Pitching Stats & Trends

Opponents have a groundball rate of just 40% against White Sox pitchers this season — 3rd lowest in MLB.

White Sox pitchers have an ERA of 3.20 (374.1 IP) against division opponents this season — 2nd best in MLB.

The White Sox have won 47% of home games in which their opponents scored first this season — 2nd highest in MLB.

The longest HR allowed by the White Sox pitchers this season traveled 460.0 feet — — tied for 3rd longest in MLB

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 127 double plays in 1,103 opportunities (12%) this season — best in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 89.5 MPH this season (3,526 balls in play) — tied for highest in MLB

Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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