• The White Sox are -125 favorites vs the Cardinals
• White Sox vs Cardinals Over / Under today: 8 Runs
• White Sox / Cardinals TV Channel: CHSN | CATV

The Chicago White Sox (-125) visit Busch Stadium to take on the St. Louis Cardinals (+105) on September 13, 2026. First pitch is scheduled for 2:15 pm in St. Louis, MO.

This season, the White Sox are 76-72 against the spread (ATS), while the Cardinals are 82-64 ATS.

White Sox vs Cardinals Starting Pitchers Today:

• White Sox starting pitcher: Undecided 0-0, 0.00 ERA
• Cardinals starting pitcher: Michael McGreevy 6-9, 3.95 ERA

White Sox vs. Cardinals Odds, Run Line, Over/Under & Moneyline

White Sox vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Sam Antonacci has hit the Hits Under in 15 of his last 25 away games (+15.05 Units / 60% ROI)
• Miguel Vargas has hit the Singles Over in 17 of his last 25 games (+12.80 Units / 51% ROI)
• Miguel Vargas has hit the Walks Over in 16 of his last 25 games (+12.45 Units / 50% ROI)
• Miguel Vargas has hit the RBIs Under in his last 10 away games (+10.00 Units / 45% ROI)
• Braden Montgomery has hit the Runs Under in 20 of his last 25 away games (+9.90 Units / 20% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Leonardo Bernal has hit the Home Runs Over in 3 of his last 10 games (+17.50 Units / 175% ROI)
• Nathan Church has hit the Hits Over in 18 of his last 20 games (+15.00 Units / 44% ROI)
• Nathan Church has hit the Singles Over in 16 of his last 20 games (+13.05 Units / 61% ROI)
• Jose Fermin has hit the Runs Under in 17 of his last 20 games at home (+11.80 Units / 28% ROI)
• Alec Burleson has hit the RBIs Over in 14 of his last 25 games (+10.50 Units / 42% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 33 of their last 50 away games (+14.05 Units / 23% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 25 of their last 40 away games (+6.85 Units / 14% ROI)
• The Chicago White Sox have hit the Team Total Under in 10 of their last 14 games (+5.20 Units / 32% ROI)
• The Chicago White Sox have hit the Game Total Over in 28 of their last 50 away games (+3.90 Units / 7% ROI)
• The Chicago White Sox have hit the Moneyline in 16 of their last 30 away games (+3.85 Units / 12% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 18 of their last 22 games (+14.70 Units / 60% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 23 of their last 40 games (+14.00 Units / 30% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 23 of their last 35 games (+11.55 Units / 28% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 24 of their last 35 games (+10.85 Units / 25% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 games (+10.20 Units / 22% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 81-64 against the Run Line (+1.8 Units / 0.86% ROI).

• 76-72 when betting on the Moneyline for +9.65 Units / 5.99% ROI
• 83-63 when betting on the total runs Over for +13.65 Units / 8.39% ROI
• 63-83 when betting on the total runs Under for -28.5 Units / -17.48% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 82-64 against the Run Line (+3.35 Units / 1.62% ROI).

• 73-76 when betting on the Moneyline for +3.65 Units / 2.25% ROI
• 69-73 when betting on the total runs Over for -11.65 Units / -7.09% ROI
• 73-69 when betting on the total runs Under for -2.95 Units / -1.8% ROI

White Sox Keys to the Game vs. the Cardinals

The White Sox are 15-5 (.750) when tied entering the 7th inning this season — 2nd best in MLB.

The White Sox are 23-28 (.451) when their opponents score in the first inning this season — 3rd best in MLB.

The White Sox are just 29-14 (.674) when they’ve had 10 or more hits this season — 3rd lowest in MLB.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

Cardinals Keys to the Game vs. the White Sox

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are just 28-17 (.622) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 66-33 (.667) when they’ve had 10 or more hits since the 2025 season — 3rd lowest in MLB.

The Cardinals are just 13-25 (.342) when tied entering the 8th inning since the 2025 season — lowest in MLB.

White Sox Hitting Stats & Trends

The White Sox are 43-19 (.694) against the run line (24.7% ROI) vs bottom 10 scoring offenses this season Today, they face the Cardinals (11th in runs scored).

White Sox hitters have grounded into 67 double plays in 1,062 opportunities (6%) this season — best in MLB.

White Sox hitters have 131 extra-base hits out of 335 total hits (39%) against LHP this season — best in MLB.

White Sox hitters have 68 extra-base hits out of 141 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OBP of .358 (665 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

The Cardinals are batting .280 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

Cardinals hitters have an OPS of just .671 (2,712 PA’s) at home this season — 2nd lowest in MLB.

White Sox Pitching Stats & Trends

Opponents have a groundball rate of just 40% against White Sox pitchers this season — 3rd lowest in MLB.

The White Sox have won 47% of home games in which their opponents scored first this season — 2nd highest in MLB.

White Sox pitchers have an ERA of 3.20 (374.1 IP) against division opponents this season — 2nd best in MLB.

The longest HR allowed by the White Sox pitchers this season traveled 460.0 feet — — tied for 3rd longest in MLB

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — 5th highest in MLB.

Cardinals pitchers have 178 three-pitch strikeouts this season — 3rd fewest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 89.5 MPH (3,526 batted balls) this season — tied for highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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