• The Diamondbacks are -155 favorites vs the White Sox
• White Sox vs Diamondbacks Over / Under today: 9 Runs
• White Sox / Diamondbacks TV Channel: CHSN | DBTV

The Chicago White Sox (+125) visit Chase Field to take on the Arizona Diamondbacks (-155) on April 22, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the White Sox are 9-14 against the spread (ATS), while the Diamondbacks are 17-6 ATS.

White Sox vs Diamondbacks Starting Pitchers Today:

• White Sox starting pitcher: Anthony Kay 1-0, 2.55 ERA
• Diamondbacks starting pitcher: Eduardo Rodriguez 1-0, 1.96 ERA

White Sox vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

White Sox vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Wednesday‘s MLB game with 57.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Munetaka Murakami has hit the Home Runs Over in 5 of his last 7 games (+17.60 Units / 251% ROI)
• Edgar Quero has hit the Runs Under in his last 10 games (+10.00 Units / 44% ROI)
• Miguel Vargas has hit the Walks Over in 14 of his last 25 games (+8.45 Units / 34% ROI)
• Miguel Vargas has hit the Singles Under in 15 of his last 20 games (+7.70 Units / 25% ROI)
• Chase Meidroth has hit the Total Bases Under in 14 of his last 20 away games (+7.30 Units / 23% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Ildemaro Vargas has hit the Home Runs Over in 2 of his last 6 games at home (+18.00 Units / 300% ROI)
• Ildemaro Vargas has hit the Hits Over in his last 15 games (+15.00 Units / 52% ROI)
• Ildemaro Vargas has hit the Runs Over in 8 of his last 10 games (+10.30 Units / 103% ROI)
• Jose Fernandez has hit the Singles Over in 12 of his last 15 games (+9.68 Units / 62% ROI)
• Ildemaro Vargas has hit the Total Bases Over in 11 of his last 15 games (+9.55 Units / 50% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 50 away games (+10.55 Units / 16% ROI)
• The Chicago White Sox have hit the Team Total Over in 30 of their last 50 away games (+8.35 Units / 14% ROI)
• The Chicago White Sox have hit the Game Total Over in 29 of their last 50 away games (+7.15 Units / 13% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 12 of their last 21 games (+6.70 Units / 32% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in their last 5 games (+5.00 Units / 85% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 34 of their last 50 games (+17.90 Units / 32% ROI)
• The Arizona Diamondbacks have covered the Run Line in 33 of their last 50 games (+10.70 Units / 15% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 21 games at home (+10.10 Units / 39% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 23 of their last 35 games at home (+9.95 Units / 22% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 22 of their last 40 games at home (+9.55 Units / 18% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 11-12 against the Run Line (-6.95 Units / -20.75% ROI).

• 9-14 when betting on the Moneyline for -1.6 Units / -6.93% ROI
• 15-8 when betting on the total runs Over for +6.1 Units / 24.11% ROI
• 8-15 when betting on the total runs Under for -8.6 Units / -33.99% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 17-6 against the Run Line (+9.15 Units / 27.52% ROI).

• 13-10 when betting on the Moneyline for +4.6 Units / 18.29% ROI
• 14-8 when betting on the total runs Over for +5.3 Units / 20.78% ROI
• 8-14 when betting on the total runs Under for -7.1 Units / -28.29% ROI

Diamondbacks vs White Sox Home Run Prop Bets Today

Diamondbacks vs White Sox Total Hits Prop Bets Today

Diamondbacks vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Diamondbacks

The White Sox are just 55-18 (.753) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .874.

The White Sox are just 63-7 (.900) when leading entering the 9th inning since the 2025 season — lowest in MLB; League Avg: .956.

The White Sox are just 88-41 (.682) when leading entering the 7th inning since the 2024 season — lowest in MLB; League Avg: .866.

The White Sox are just 106-202 (.344) when allowing 5 or more extra base hits since the 2024 season — lowest in MLB; League Avg: .535.

Diamondbacks Keys to the Game vs. the White Sox

The Diamondbacks are just 79-7 (.919) when leading entering the 9th inning since the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks are just 76-15 (.835) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .907.

The Diamondbacks are 2-6 (.250) when trailing entering the 8th inning this season — tied for 3rd best in MLB; League Avg: .105.

The Diamondbacks are just 69-20 (.775) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .874.

White Sox Hitting Stats & Trends

The White Sox have a winning percentage of just 32% since the 2024 season — lowest in MLB.

White Sox hitters slugged just .364 against RHP in the 2025 season — 2nd lowest in MLB.

White Sox hitters have an OPS of just .645 (9,435 PA’s) against RHP since the 2024 season — lowest in MLB.

The White Sox won just 55% of games in which they have scored first at home in the 2025 season — 2nd lowest in MLB.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have 53 extra-base hits out of 121 total hits (44%) against RHP this season — best in MLB.

Diamondbacks hitters have an OBP of just .285 (590 PA’s) against RHP this season — tied for lowest in MLB.

Diamondbacks hitters have a groundball batting average of just .151 with runners on base this season — lowest in MLB.

Diamondbacks hitters have chased 49% of pitches out of the zone with two-strikes this season — highest in MLB.

White Sox Pitching Stats & Trends

Opponents have a miss rate of just 22% against White Sox pitchers this season — 2nd lowest in MLB.

White Sox pitchers had a first-pitch strike rate of just 59% in the 2025 season — lowest in MLB.

White Sox pitchers have walked 10% of batters since the 2024 season — highest in MLB.

The White Sox have won just 15% of games in which their opponents scored first since the 2024 season — lowest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have walked 4% of batters when facing the leadoff batter in the inning this season — best in MLB.

Opponents had a miss rate of just 24% against Diamondbacks pitchers in the 2025 season — tied for 5th lowest in MLB.

Diamondbacks pitchers have walked 4% of batters when facing the leadoff batter in the inning this month (18 games) — best in MLB.

Diamondbacks pitchers have not walked any of the 46 batters that they have faced when facing the leadoff batter in the inning over the past seven days (5 games) — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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